8a4a - Revision history

OCA at 13:36, 1 February 2024

2024-02-01T13:36:30Z

← Older revision		Revision as of 13:36, 1 February 2024
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	====		==Structure of human Rep15 in complex with bovine Rab3C.==
	<StructureSection load='8a4a' size='340' side='right'caption='[[8a4a]]' scene=''>		<StructureSection load='8a4a' size='340' side='right'caption='[[8a4a]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>		<table><tr><td colspan='2'>[[8a4a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A4A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A4A FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a4a OCA], [https://pdbe.org/8a4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a4a RCSB], [https://www.ebi.ac.uk/pdbsum/8a4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a4a ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.52Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a4a OCA], [https://pdbe.org/8a4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a4a RCSB], [https://www.ebi.ac.uk/pdbsum/8a4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a4a ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/RAB3C_BOVIN RAB3C_BOVIN] Protein transport. Probably involved in vesicular traffic (By similarity).
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			In their GTP-bound (active) form, Rab proteins interact with effector proteins that control downstream signaling. One such Rab15 effector is Rep15, which is known to have a role in receptor recycling from the endocytic recycling compartment but otherwise remains poorly characterized. Here, we report the characterization of the Rep15:Rab15 interaction and identification of Rab3 paralogs and Rab34 as Rep15 interacting partners from a yeast two-hybrid assay. Biochemical validation of the interactions is presented and crystal structures of the Rep15:Rab3B and Rep15:Rab3C complexes provide additional mechanistic insight. We find that Rep15 adopts a globular structure that is distinct from other reported Rab15, Rab3 and Rab34 effectors. Structure-based mutagenesis experiments explain the Rep15:Rab interaction specificity. Rep15 depletion in U138MG glioblastoma cells impairs cell proliferation, cell migration and receptor recycling, underscoring the need for further clarification of the role of Rep15 in cancer.

			Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector.,Rai A, Singh AK, Bleimling N, Posern G, Vetter IR, Goody RS Nat Commun. 2022 Jul 23;13(1):4262. doi: 10.1038/s41467-022-31831-1. PMID:35871249<ref>PMID:35871249</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 8a4a" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Ras-related protein Rab 3D structures\|Ras-related protein Rab 3D structures]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Bos taurus]]
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Z-disk~~]]		[[Category: Goody RS]]
			[[Category: Rai A]]
			[[Category: Vetter IR]]

OCA at 05:03, 10 August 2022

2022-08-10T05:03:42Z

← Older revision		Revision as of 05:03, 10 August 2022
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8a4a ~~is ON HOLD until Paper Publication~~		====
			<StructureSection load='8a4a' size='340' side='right'caption='[[8a4a]]' scene=''>
	~~Authors~~: ~~Rai, A~~.~~, Vetter, I~~.R.~~, Goody, R~~.S.		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
	~~Description~~: ~~Structure of human Rep15 in complex with bovine Rab3C~~.		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a4a OCA], [https://pdbe.org/8a4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a4a RCSB], [https://www.ebi.ac.uk/pdbsum/8a4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a4a ProSAT]</span></td></tr>
	[[~~Category~~: ~~Unreleased Structures~~]]		</table>
	[[~~Category~~: ~~Goody, R~~.S]]		__TOC__
	[[Category: ~~Vetter, I.R~~]]		</StructureSection>
	[[Category: ~~Rai, A~~]]		[[Category: Large Structures]]
			[[Category: Z-disk]]

OCA at 06:19, 29 June 2022

2022-06-29T06:19:40Z

← Older revision		Revision as of 06:19, 29 June 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8a4a is ON HOLD		The entry 8a4a is ON HOLD until Paper Publication

	Authors: Rai, A., Vetter, I.R., Goody, R.S.		Authors: Rai, A., Vetter, I.R., Goody, R.S.
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	Description: Structure of human Rep15 in complex with bovine Rab3C.		Description: Structure of human Rep15 in complex with bovine Rab3C.
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
			[[Category: Goody, R.S]]
	[[Category: Vetter, I.R]]		[[Category: Vetter, I.R]]
	~~[[Category: Goody, R.S]]~~
	[[Category: Rai, A]]		[[Category: Rai, A]]

OCA: Protected "8a4a" [edit=sysop:move=sysop]

2022-06-22T07:18:25Z

Protected "8a4a" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:18, 22 June 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8a4a is ON HOLD Authors: Rai, A., Vetter, I.R., Goody, R.S. Description: Structure of human Rep15 in complex with bovine Rab3C. [[Category: Unrelea...

2022-06-22T07:18:24Z

New page: '''Unreleased structure''' The entry 8a4a is ON HOLD Authors: Rai, A., Vetter, I.R., Goody, R.S. Description: Structure of human Rep15 in complex with bovine Rab3C. [[Category: Unrelea...

New page

'''Unreleased structure'''

The entry 8a4a is ON HOLD

Authors: Rai, A., Vetter, I.R., Goody, R.S.

Description: Structure of human Rep15 in complex with bovine Rab3C.
[[Category: Unreleased Structures]]
[[Category: Vetter, I.R]]
[[Category: Goody, R.S]]
[[Category: Rai, A]]