8a64 - Revision history

OCA at 07:00, 21 November 2024

2024-11-21T07:00:54Z

← Older revision		Revision as of 07:00, 21 November 2024
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	==cryoEM structure of the catalytically inactive EndoS from S. pyogenes in complex with the Fc region of immunoglobulin G1==		==cryoEM structure of the catalytically inactive EndoS from S. pyogenes in complex with the Fc region of immunoglobulin G1.==
	<StructureSection load='8a64' size='340' side='right'caption='[[8a64]], [[Resolution\|resolution]] 4.60Å' scene=''>		<StructureSection load='8a64' size='340' side='right'caption='[[8a64]], [[Resolution\|resolution]] 4.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/~~J7M8R4_STRP1 J7M8R4_STRP1~~]		[https://www.uniprot.org/uniprot/ENDOS_STRP1 ENDOS_STRP1] Endoglucosidase that acts as a host immune evasion factor by mediating hydrolysis of the N-linked glycan from the Fc region of host immunoglobulin-gamma (IgG) during infection (PubMed:11406581, PubMed:11598100, PubMed:12438337, PubMed:18182097, PubMed:20357243, PubMed:21619648, PubMed:22551167, PubMed:22747414, PubMed:24668806, PubMed:24753590, PubMed:29760474, PubMed:30102520, PubMed:31092533). Specifically catalyzes the hydrolysis of the beta-1,4 linkage between the first two N-acetylglucosamine residues of the complex-type N-linked glycan located on 'Asn-297' of the Fc region of IgG antibodies (IGHG1, IGHG2, IGHG3 or IGHG4), thereby preventing interaction between IgGs and Fc receptors and ability to activate the complement pathway (PubMed:11406581, PubMed:11598100, PubMed:12438337, PubMed:20357243, PubMed:21619648, PubMed:31092533). Shows a specificity for biantennary complex type N-glycans; does neither cleave larger complex type glycans nor oligomannose and nor hybrid-type glycans (PubMed:22551167, PubMed:26156869). Specifically acts on IgGs; does not act on immunoglobulin alpha, beta, delta or mu (PubMed:11598100).<ref>PMID:11406581</ref> <ref>PMID:11598100</ref> <ref>PMID:12438337</ref> <ref>PMID:18182097</ref> <ref>PMID:20357243</ref> <ref>PMID:21619648</ref> <ref>PMID:22551167</ref> <ref>PMID:22747414</ref> <ref>PMID:24668806</ref> <ref>PMID:24753590</ref> <ref>PMID:26156869</ref> <ref>PMID:29760474</ref> <ref>PMID:30102520</ref> <ref>PMID:31092533</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:50, 26 July 2023

2023-07-26T12:50:01Z

← Older revision		Revision as of 12:50, 26 July 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8a64]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A64 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8a64]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A64 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.6Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a64 OCA], [https://pdbe.org/8a64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a64 RCSB], [https://www.ebi.ac.uk/pdbsum/8a64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a64 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a64 OCA], [https://pdbe.org/8a64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a64 RCSB], [https://www.ebi.ac.uk/pdbsum/8a64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a64 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:26, 7 April 2023

2023-04-07T06:26:08Z

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-The entry 8a64 is ON HOLD  until Paper Publication
+==cryoEM structure of the catalytically inactive EndoS from S. pyogenes in complex with the Fc region of immunoglobulin G1==
-Authors:
+Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases.,Trastoy B, Du JJ, Cifuente JO, Rudolph L, Garcia-Alija M, Klontz EH, Deredge D, Sultana N, Huynh CG, Flowers MW, Li C, Sastre DE, Wang LX, Corzana F, Mallagaray A, Sundberg EJ, Guerin ME Nat Commun. 2023 Mar 27;14(1):1705. doi: 10.1038/s41467-023-37215-3. PMID:36973249<ref>PMID:36973249</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>

OCA at 05:26, 8 March 2023

2023-03-08T05:26:06Z

← Older revision		Revision as of 05:26, 8 March 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8a64 is ON HOLD		The entry 8a64 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 04:53, 8 February 2023

2023-02-08T04:53:03Z

← Older revision		Revision as of 04:53, 8 February 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8a64 is ON HOLD ~~until Paper Publication~~		The entry 8a64 is ON HOLD

	Authors:		Authors:

OCA at 07:43, 24 November 2022

2022-11-24T07:43:04Z

← Older revision		Revision as of 07:43, 24 November 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8a64 is ON HOLD		The entry 8a64 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 05:04, 3 November 2022

2022-11-03T05:04:24Z

← Older revision		Revision as of 05:04, 3 November 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8a64 is ON HOLD ~~until Paper Publication~~		The entry 8a64 is ON HOLD

	Authors:		Authors:

OCA at 16:31, 27 July 2022

2022-07-27T16:31:39Z

← Older revision		Revision as of 16:31, 27 July 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8a64 is ON HOLD		The entry 8a64 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8a64" [edit=sysop:move=sysop]

2022-06-22T07:22:24Z

Protected "8a64" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:22, 22 June 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8a64 is ON HOLD Authors: Description: Category: Unreleased Structures

2022-06-22T07:22:23Z

New page: '''Unreleased structure''' The entry 8a64 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8a64 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]