8a67 - Revision history

OCA at 06:11, 31 July 2024

2024-07-31T06:11:22Z

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 </table>
 == Function ==
-[https://www.uniprot.org/uniprot/J3QS39_HUMAN J3QS39_HUMAN]
+[https://www.uniprot.org/uniprot/UBB_HUMAN UBB_HUMAN] Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.<ref>PMID:16543144</ref> <ref>PMID:19754430</ref>
 __TOC__
 </StructureSection>

OCA at 08:09, 7 February 2024

2024-02-07T08:09:16Z

← Older revision		Revision as of 08:09, 7 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8a67]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A67 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A67 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8a67]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A67 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A67 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.86Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a67 OCA], [https://pdbe.org/8a67 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a67 RCSB], [https://www.ebi.ac.uk/pdbsum/8a67 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a67 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a67 OCA], [https://pdbe.org/8a67 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a67 RCSB], [https://www.ebi.ac.uk/pdbsum/8a67 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a67 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:25, 15 February 2023

2023-02-15T10:25:33Z

← Older revision		Revision as of 10:25, 15 February 2023
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8a67 is ~~ON HOLD until Paper Publication~~		==Branched Lys48- and Lys63-linked tri-ubiquitin (K48-K63-Ub3) in complex with matured synthetic nanobody NbSL3.3Q (3rd generation)==
			<StructureSection load='8a67' size='340' side='right'caption='[[8a67]], [[Resolution\|resolution]] 1.86Å' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>[[8a67]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A67 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A67 FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a67 OCA], [https://pdbe.org/8a67 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a67 RCSB], [https://www.ebi.ac.uk/pdbsum/8a67 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a67 ProSAT]</span></td></tr>
			</table>
			== Function ==
			[https://www.uniprot.org/uniprot/J3QS39_HUMAN J3QS39_HUMAN]
			__TOC__
			</StructureSection>
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Synthetic construct]]
			[[Category: Kulathu Y]]
			[[Category: Lange SM]]

OCA at 04:12, 20 July 2022

2022-07-20T04:12:27Z

← Older revision		Revision as of 04:12, 20 July 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8a67 is ON HOLD		The entry 8a67 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8a67" [edit=sysop:move=sysop]

2022-06-22T07:22:30Z

Protected "8a67" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:22, 22 June 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8a67 is ON HOLD Authors: Description: Category: Unreleased Structures

2022-06-22T07:22:29Z

New page: '''Unreleased structure''' The entry 8a67 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8a67 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]