8a6e - Revision history

OCA at 19:48, 29 May 2024

2024-05-29T19:48:04Z

← Older revision		Revision as of 19:48, 29 May 2024
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a6e OCA], [https://pdbe.org/8a6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a6e RCSB], [https://www.ebi.ac.uk/pdbsum/8a6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a6e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a6e OCA], [https://pdbe.org/8a6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a6e RCSB], [https://www.ebi.ac.uk/pdbsum/8a6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a6e ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Vision is initiated by the rhodopsin family of light-sensitive G protein-coupled receptors (GPCRs)(1). A photon is absorbed by the 11-cis retinal chromophore of rhodopsin, which isomerizes within 200 femtoseconds to the all-trans conformation(2), thereby initiating the cellular signal transduction processes that ultimately lead to vision. However, the intramolecular mechanism by which the photoactivated retinal induces the activation events inside rhodopsin remains experimentally unclear. Here we use ultrafast time-resolved crystallography at room temperature(3) to determine how an isomerized twisted all-trans retinal stores the photon energy that is required to initiate the protein conformational changes associated with the formation of the G protein-binding signalling state. The distorted retinal at a 1-ps time delay after photoactivation has pulled away from half of its numerous interactions with its binding pocket, and the excess of the photon energy is released through an anisotropic protein breathing motion in the direction of the extracellular space. Notably, the very early structural motions in the protein side chains of rhodopsin appear in regions that are involved in later stages of the conserved class A GPCR activation mechanism. Our study sheds light on the earliest stages of vision in vertebrates and points to fundamental aspects of the molecular mechanisms of agonist-mediated GPCR activation.

			Ultrafast structural changes direct the first molecular events of vision.,Gruhl T, Weinert T, Rodrigues MJ, Milne CJ, Ortolani G, Nass K, Nango E, Sen S, Johnson PJM, Cirelli C, Furrer A, Mous S, Skopintsev P, James D, Dworkowski F, Bath P, Kekilli D, Ozerov D, Tanaka R, Glover H, Bacellar C, Brunle S, Casadei CM, Diethelm AD, Gashi D, Gotthard G, Guixa-Gonzalez R, Joti Y, Kabanova V, Knopp G, Lesca E, Ma P, Martiel I, Muhle J, Owada S, Pamula F, Sarabi D, Tejero O, Tsai CJ, Varma N, Wach A, Boutet S, Tono K, Nogly P, Deupi X, Iwata S, Neutze R, Standfuss J, Schertler G, Panneels V Nature. 2023 Mar;615(7954):939-944. doi: 10.1038/s41586-023-05863-6. Epub 2023 , Mar 22. PMID:36949205<ref>PMID:36949205</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 8a6e" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Rhodopsin 3D structures\|Rhodopsin 3D structures]]		*[[Rhodopsin 3D structures\|Rhodopsin 3D structures]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:09, 7 February 2024

2024-02-07T08:09:23Z

← Older revision		Revision as of 08:09, 7 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8a6e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A6E FirstGlance]. <br>		<table><tr><td colspan='2'>[[8a6e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A6E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a6e OCA], [https://pdbe.org/8a6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a6e RCSB], [https://www.ebi.ac.uk/pdbsum/8a6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a6e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a6e OCA], [https://pdbe.org/8a6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a6e RCSB], [https://www.ebi.ac.uk/pdbsum/8a6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a6e ProSAT]</span></td></tr>
	</table>		</table>

			==See Also==
			*[[Rhodopsin 3D structures\|Rhodopsin 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:47, 29 March 2023

2023-03-29T06:47:12Z

@@ Line 1: / Line 1: @@
-The entry 8a6e is ON HOLD  until Paper Publication
+==100 picosecond light activated crystal structure of bovine rhodopsin in Lipidic Cubic Phase (SACLA)==
+<StructureSection load='8a6e' size='340' side='right'caption='[[8a6e]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8a6e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A6E FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a6e OCA], [https://pdbe.org/8a6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a6e RCSB], [https://www.ebi.ac.uk/pdbsum/8a6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a6e ProSAT]</span></td></tr>

OCA at 05:04, 3 November 2022

2022-11-03T05:04:31Z

← Older revision		Revision as of 05:04, 3 November 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8a6e is ON HOLD until ~~sometime in the future~~		The entry 8a6e is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 06:20, 29 June 2022

2022-06-29T06:20:37Z

← Older revision		Revision as of 06:20, 29 June 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8a6e is ON HOLD		The entry 8a6e is ON HOLD until sometime in the future

	Authors:		Authors:

OCA: Protected "8a6e" [edit=sysop:move=sysop]

2022-06-22T07:22:47Z

Protected "8a6e" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:22, 22 June 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8a6e is ON HOLD Authors: Description: Category: Unreleased Structures

2022-06-22T07:22:46Z

New page: '''Unreleased structure''' The entry 8a6e is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8a6e is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]