8a98 - Revision history

OCA at 11:52, 23 October 2024

2024-10-23T11:52:16Z

← Older revision		Revision as of 11:52, 23 October 2024
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	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/~~Q4QBV0_LEIMA Q4QBV0_LEIMA~~]		[https://www.uniprot.org/uniprot/Q4Q8G4_LEIMA Q4Q8G4_LEIMA]
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Leishmania is the causative agent of cutaneous and visceral diseases affecting millions of individuals worldwide. Pseudouridine (Psi), the most abundant modification on rRNA, changes during the parasite life cycle. Alterations in the level of a specific Psi in helix 69 (H69) affected ribosome function. To decipher the molecular mechanism of this phenotype, we determine the structure of ribosomes lacking the single Psi and its parental strain at approximately 2.4-3 A resolution using cryo-EM. Our findings demonstrate the significance of a single Psi on H69 to its structure and the importance for its interactions with helix 44 and specific tRNAs. Our study suggests that rRNA modification affects translation of mRNAs carrying codon bias due to selective accommodation of tRNAs by the ribosome. Based on the high-resolution structures, we propose a mechanism explaining how the ribosome selects specific tRNAs.

			Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.,Rajan KS, Aryal S, Hiregange DG, Bashan A, Madmoni H, Olami M, Doniger T, Cohen-Chalamish S, Pescher P, Taoka M, Nobe Y, Fedorenko A, Bose T, Zimermann E, Prina E, Aharon-Hefetz N, Pilpel Y, Isobe T, Unger R, Spath GF, Yonath A, Michaeli S Cell Rep. 2024 May 28;43(5):114203. doi: 10.1016/j.celrep.2024.114203. Epub 2024 , May 8. PMID:38722744<ref>PMID:38722744</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 8a98" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Ribosome 3D structures\|Ribosome 3D structures]]		*[[Ribosome 3D structures\|Ribosome 3D structures]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:44, 22 May 2024

2024-05-22T10:44:57Z

← Older revision		Revision as of 10:44, 22 May 2024
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q4QBV0_LEIMA Q4QBV0_LEIMA]		[https://www.uniprot.org/uniprot/Q4QBV0_LEIMA Q4QBV0_LEIMA]

			==See Also==
			*[[Ribosome 3D structures\|Ribosome 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 05:55, 11 October 2023

2023-10-11T05:55:16Z

← Older revision		Revision as of 05:55, 11 October 2023
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8a98 is ~~ON HOLD until Paper Publication~~		==CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT==
			<StructureSection load='8a98' size='340' side='right'caption='[[8a98]], [[Resolution\|resolution]] 2.46Å' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>[[8a98]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major_strain_Friedlin Leishmania major strain Friedlin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A98 FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.46Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1MA:6-HYDRO-1-METHYLADENOSINE-5-MONOPHOSPHATE'>1MA</scene>, <scene name='pdbligand=5MC:5-METHYLCYTIDINE-5-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=A2M:2-O-METHYLADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>A2M</scene>, <scene name='pdbligand=C4J:(5S)-5-{3-[(3S)-3-amino-3-carboxypropyl]-1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl}-2,5-anhydro-1-O-phosphono-L-arabinitol'>C4J</scene>, <scene name='pdbligand=G7M:N7-METHYL-GUANOSINE-5-MONOPHOSPHATE'>G7M</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MA6:6N-DIMETHYLADENOSINE-5-MONOPHOSHATE'>MA6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a98 OCA], [https://pdbe.org/8a98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a98 RCSB], [https://www.ebi.ac.uk/pdbsum/8a98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a98 ProSAT]</span></td></tr>
			</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q4QBV0_LEIMA Q4QBV0_LEIMA]
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Leishmania major strain Friedlin]]
			[[Category: Bashan A]]
			[[Category: Rajan KS]]
			[[Category: Yonath A]]

OCA at 16:35, 19 October 2022

2022-10-19T16:35:49Z

← Older revision		Revision as of 16:35, 19 October 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8a98 is ON HOLD		The entry 8a98 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8a98" [edit=sysop:move=sysop]

2022-07-06T15:05:15Z

Protected "8a98" [edit=sysop:move=sysop]

← Older revision	Revision as of 15:05, 6 July 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8a98 is ON HOLD Authors: Description: Category: Unreleased Structures

2022-07-06T15:05:14Z

New page: '''Unreleased structure''' The entry 8a98 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8a98 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]