8amn - Revision history

OCA at 08:12, 7 February 2024

2024-02-07T08:12:44Z

← Older revision		Revision as of 08:12, 7 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8amn]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AMN FirstGlance]. <br>		<table><tr><td colspan='2'>[[8amn]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AMN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.46Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8amn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8amn OCA], [https://pdbe.org/8amn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8amn RCSB], [https://www.ebi.ac.uk/pdbsum/8amn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8amn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8amn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8amn OCA], [https://pdbe.org/8amn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8amn RCSB], [https://www.ebi.ac.uk/pdbsum/8amn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8amn ProSAT]</span></td></tr>
	</table>		</table>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	The self-complementary triplet 5'UGG3'/5'UGG3' is a particular structural motif containing noncanonical G-G pair and two U.G wobble pairs. It constitutes a specific structural and electrostatic environment attracting metal ions, particularly Ba2+ ions. Crystallographic research has shown that two Ba2+ cations are located in the major groove of the helix and interact directly with the UGG triplet. A comparison with the unliganded structure has revealed global changes in the RNA structure in the presence of metal ions, whereas thermodynamic measurements have shown increased stability. Moreover, in the structure with Ba2+, an unusual noncanonical G(syn)-G(syn) pair is observed instead of the common G(anti)-G(syn). We further elucidate the metal binding properties of the UGG/UGG triplet by performing crystallographic and thermodynamic studies using DSC and UV melting with other metal ions. The results explain the preferences of the UGG sequence for Ba2+ cations and point to possible applications of this metal-binding propensity.

	Structure and thermodynamics of a UGG motif interacting with Ba2+ and other metal ions: accommodating changes in the RNA structure and the presence of a G(syn)-G(syn) pair.,Kiliszek A, Pluta M, Bejger M, Rypniewski W RNA. 2022 Nov 1:rna.079414.122. doi: 10.1261/rna.079414.122. PMID:36319090<ref>PMID:36319090</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 8amn" style="background-color:#fffaf0;"></div>~~
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:13, 24 November 2022

2022-11-24T10:13:46Z

← Older revision		Revision as of 10:13, 24 November 2022
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8amn is ~~ON HOLD until Paper~~ Publication		==Crystal structure of AUGUGGCAU duplex with strontium ions==
			<StructureSection load='8amn' size='340' side='right'caption='[[8amn]], [[Resolution\|resolution]] 2.46Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[8amn]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AMN FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8amn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8amn OCA], [https://pdbe.org/8amn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8amn RCSB], [https://www.ebi.ac.uk/pdbsum/8amn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8amn ProSAT]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The self-complementary triplet 5'UGG3'/5'UGG3' is a particular structural motif containing noncanonical G-G pair and two U.G wobble pairs. It constitutes a specific structural and electrostatic environment attracting metal ions, particularly Ba2+ ions. Crystallographic research has shown that two Ba2+ cations are located in the major groove of the helix and interact directly with the UGG triplet. A comparison with the unliganded structure has revealed global changes in the RNA structure in the presence of metal ions, whereas thermodynamic measurements have shown increased stability. Moreover, in the structure with Ba2+, an unusual noncanonical G(syn)-G(syn) pair is observed instead of the common G(anti)-G(syn). We further elucidate the metal binding properties of the UGG/UGG triplet by performing crystallographic and thermodynamic studies using DSC and UV melting with other metal ions. The results explain the preferences of the UGG sequence for Ba2+ cations and point to possible applications of this metal-binding propensity.

	~~Authors~~: Kiliszek, A., Rypniewski, W.		Structure and thermodynamics of a UGG motif interacting with Ba2+ and other metal ions: accommodating changes in the RNA structure and the presence of a G(syn)-G(syn) pair.,Kiliszek A, Pluta M, Bejger M, Rypniewski W RNA. 2022 Nov 1:rna.079414.122. doi: 10.1261/rna.079414.122. PMID:36319090<ref>PMID:36319090</ref>

	~~Description~~: ~~Crystal structure of AUGUGGCAU duplex with strontium ions~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	[[Category: ~~Unreleased Structures~~]]		</div>
	[[Category: ~~Rypniewski, W~~]]		<div class="pdbe-citations 8amn" style="background-color:#fffaf0;"></div>
	[[Category: Kiliszek, A]]		== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Kiliszek A]]
			[[Category: Rypniewski W]]

OCA at 05:23, 31 August 2022

2022-08-31T05:23:59Z

← Older revision		Revision as of 05:23, 31 August 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8amn is ON HOLD		The entry 8amn is ON HOLD until Paper Publication

	Authors: Kiliszek, A., Rypniewski, W.		Authors: Kiliszek, A., Rypniewski, W.

OCA: Protected "8amn" [edit=sysop:move=sysop]

2022-08-10T03:58:09Z

Protected "8amn" [edit=sysop:move=sysop]

← Older revision	Revision as of 03:58, 10 August 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8amn is ON HOLD Authors: Kiliszek, A., Rypniewski, W. Description: Crystal structure of AUGUGGCAU duplex with strontium ions [[Category: Unreleased...

2022-08-10T03:58:08Z

New page: '''Unreleased structure''' The entry 8amn is ON HOLD Authors: Kiliszek, A., Rypniewski, W. Description: Crystal structure of AUGUGGCAU duplex with strontium ions [[Category: Unreleased...

New page

'''Unreleased structure'''

The entry 8amn is ON HOLD

Authors: Kiliszek, A., Rypniewski, W.

Description: Crystal structure of AUGUGGCAU duplex with strontium ions
[[Category: Unreleased Structures]]
[[Category: Rypniewski, W]]
[[Category: Kiliszek, A]]