8bbf - Revision history

OCA at 06:47, 24 July 2024

2024-07-24T06:47:52Z

← Older revision		Revision as of 06:47, 24 July 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8bbf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BBF FirstGlance]. <br>		<table><tr><td colspan='2'>[[8bbf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BBF FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bbf OCA], [https://pdbe.org/8bbf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bbf RCSB], [https://www.ebi.ac.uk/pdbsum/8bbf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bbf ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 8Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bbf OCA], [https://pdbe.org/8bbf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bbf RCSB], [https://www.ebi.ac.uk/pdbsum/8bbf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bbf ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[https://www.uniprot.org/uniprot/~~WDR19_HUMAN WDR19_HUMAN~~] ~~Jeune syndrome~~;~~Senior~~-~~Loken~~ syndrome;Juvenile nephronophthisis;Cranioectodermal dysplasia. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.		[https://www.uniprot.org/uniprot/IF122_HUMAN IF122_HUMAN] Cranioectodermal dysplasia;Short rib-polydactyly syndrome, Beemer-Langer type. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/~~WDR19_HUMAN WDR19_HUMAN~~] As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is ~~involved~~ in ~~cilia function~~ and~~/or assembly~~ (PubMed:~~20889716~~). ~~Essential for functional~~ IFT-A ~~assembly~~ and ~~ciliary entry of GPCRs (PubMed:20889716~~). ~~Associates with~~ the ~~BBSome~~ complex to ~~mediate ciliary~~ transport (~~By similarity~~).~~[UniProtKB~~:~~Q3UGF1]~~<ref>PMID:~~20889716~~</ref>		[https://www.uniprot.org/uniprot/IF122_HUMAN IF122_HUMAN] As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking (PubMed:27932497, PubMed:29220510). Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity).[UniProtKB:Q6NWV3]<ref>PMID:27932497</ref> <ref>PMID:29220510</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Intraflagellar transport (IFT) trains are massive molecular machines that traffic proteins between cilia and the cell body. Each IFT train is a dynamic polymer of two large complexes (IFT-A and -B) and motor proteins, posing a formidable challenge to mechanistic understanding. Here, we reconstituted the complete human IFT-A complex and obtained its structure using cryo-EM. Combined with AlphaFold prediction and genome-editing studies, our results illuminate how IFT-A polymerizes, interacts with IFT-B, and uses an array of beta-propeller and TPR domains to create "carriages" of the IFT train that engage TULP adaptor proteins. We show that IFT-AâTULP carriages are essential for cilia localization of diverse membrane proteins, as well as ICK-the key kinase regulating IFT train turnaround. These data establish a structural link between IFT-A's distinct functions, provide a blueprint for IFT-A in the train, and shed light on how IFT evolved from a proto-coatomer ancestor.

			IFT-A structure reveals carriages for membrane protein transport into cilia.,Hesketh SJ, Mukhopadhyay AG, Nakamura D, Toropova K, Roberts AJ Cell. 2022 Dec 22;185(26):4971-4985.e16. doi: 10.1016/j.cell.2022.11.010. Epub , 2022 Dec 2. PMID:36462505<ref>PMID:36462505</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 8bbf" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:19, 7 December 2022

2022-12-07T08:19:06Z

@@ Line 1: / Line 1: @@
-The entry 8bbf is ON HOLD
+==Structure of the IFT-A complex; IFT-A1 module==
+<StructureSection load='8bbf' size='340' side='right'caption='[[8bbf]], [[Resolution|resolution]] 8.00&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8bbf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BBF FirstGlance]. <br>
-Description:
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bbf OCA], [https://pdbe.org/8bbf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bbf RCSB], [https://www.ebi.ac.uk/pdbsum/8bbf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bbf ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>

OCA: Protected "8bbf" [edit=sysop:move=sysop]

2022-10-19T17:03:57Z

Protected "8bbf" [edit=sysop:move=sysop]

← Older revision	Revision as of 17:03, 19 October 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8bbf is ON HOLD Authors: Description: Category: Unreleased Structures

2022-10-19T17:03:56Z

New page: '''Unreleased structure''' The entry 8bbf is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8bbf is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]