8bc2 - Revision history

OCA at 16:48, 9 July 2025

2025-07-09T16:48:40Z

← Older revision		Revision as of 16:48, 9 July 2025
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	<StructureSection load='8bc2' size='340' side='right'caption='[[8bc2]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='8bc2' size='340' side='right'caption='[[8bc2]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8bc2]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Priestia_megaterium_DSM_319~~ Priestia ~~megaterium DSM 319~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BC2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8bc2]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_aryabhattai Priestia aryabhattai]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BC2 FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.6Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.6Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bc2 OCA], [https://pdbe.org/8bc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bc2 RCSB], [https://www.ebi.ac.uk/pdbsum/8bc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bc2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bc2 OCA], [https://pdbe.org/8bc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bc2 RCSB], [https://www.ebi.ac.uk/pdbsum/8bc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bc2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/~~A0A7W3N5X5_9BACI A0A7W3N5X5_9BACI~~]		[https://www.uniprot.org/uniprot/SFTAL_PRIM1 SFTAL_PRIM1] Part of the sulfo-TAL (or sulfo-SFT) pathway, a D-sulfoquinovose degradation pathway that produces sulfolactate (SL) (PubMed:33036753). Catalyzes the conversion of 6-deoxy-6-sulfo-D-fructose (SF) and glyceraldehyde 3-phosphate (GAP) into fructose-6-phosphate (F6P) and 3-sulfolactaldehyde (SLA) (PubMed:33036753, PubMed:36805128). Can also catalyze the SF-cleavage with erythrose 4-phosphate (E4P) as acceptor, forming 3-sulfolactaldehyde (SLA) and sedoheptulose 7-phosphate (S7P) (PubMed:36805128).<ref>PMID:33036753</ref> <ref>PMID:36805128</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Sulfoquinovose (SQ) is a key component of plant sulfolipids (sulfoquinovosyl diacylglycerols) and a major environmental reservoir of biological sulfur. Breakdown of SQ is achieved by bacteria through the pathways of sulfoglycolysis. The sulfoglycolytic sulfofructose transaldolase (sulfo-SFT) pathway is used by gut-resident firmicutes and soil saprophytes. After isomerization of SQ to sulfofructose (SF), the namesake enzyme catalyzes the transaldol reaction of SF transferring dihydroxyacetone to 3C/4C acceptors to give sulfolactaldehyde and fructose-6-phosphate or sedoheptulose-7-phosphate. We report the 3D cryo-EM structure of SF transaldolase from Bacillus megaterium in apo and ligand bound forms, revealing a decameric structure formed from two pentameric rings of the protomer. We demonstrate a covalent "Schiff base" intermediate formed by reaction of SF with Lys89 within a conserved Asp-Lys-Glu catalytic triad and defined by an Arg-Trp-Arg sulfonate recognition triad. The structural characterization of the signature enzyme of the sulfo-SFT pathway provides key insights into molecular recognition of the sulfonate group of sulfosugars.

			Structure and mechanism of sulfofructose transaldolase, a key enzyme in sulfoquinovose metabolism.,Snow AJD, Sharma M, Abayakoon P, Williams SJ, Blaza JN, Davies GJ Structure. 2023 Mar 2;31(3):244-252.e4. doi: 10.1016/j.str.2023.01.010. Epub 2023 , Feb 17. PMID:36805128<ref>PMID:36805128</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 8bc2" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Priestia ~~megaterium DSM 319~~]]		[[Category: Priestia aryabhattai]]
	[[Category: Blaza J]]		[[Category: Blaza J]]
	[[Category: Davies GJ]]		[[Category: Davies GJ]]
	[[Category: Sharma M]]		[[Category: Sharma M]]
	[[Category: Snow AJD]]		[[Category: Snow AJD]]

OCA at 11:25, 15 November 2023

2023-11-15T11:25:17Z

← Older revision		Revision as of 11:25, 15 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8bc2]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium_DSM_319 Priestia megaterium DSM 319]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BC2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8bc2]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium_DSM_319 Priestia megaterium DSM 319]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BC2 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bc2 OCA], [https://pdbe.org/8bc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bc2 RCSB], [https://www.ebi.ac.uk/pdbsum/8bc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bc2 ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.6Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bc2 OCA], [https://pdbe.org/8bc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bc2 RCSB], [https://www.ebi.ac.uk/pdbsum/8bc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bc2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:28, 18 January 2023

2023-01-18T07:28:02Z

← Older revision		Revision as of 07:28, 18 January 2023
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8bc2 is ~~ON HOLD~~		==Ligand-Free Structure of the decameric sulfofructose transaldolase BmSF-TAL==
			<StructureSection load='8bc2' size='340' side='right'caption='[[8bc2]], [[Resolution\|resolution]] 2.60Å' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>[[8bc2]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium_DSM_319 Priestia megaterium DSM 319]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BC2 FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bc2 OCA], [https://pdbe.org/8bc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bc2 RCSB], [https://www.ebi.ac.uk/pdbsum/8bc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bc2 ProSAT]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/A0A7W3N5X5_9BACI A0A7W3N5X5_9BACI]
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Priestia megaterium DSM 319]]
			[[Category: Blaza J]]
			[[Category: Davies GJ]]
			[[Category: Sharma M]]
			[[Category: Snow AJD]]

OCA: Protected "8bc2" [edit=sysop:move=sysop]

2022-10-26T03:51:18Z

Protected "8bc2" [edit=sysop:move=sysop]

← Older revision	Revision as of 03:51, 26 October 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8bc2 is ON HOLD Authors: Description: Category: Unreleased Structures

2022-10-26T03:51:17Z

New page: '''Unreleased structure''' The entry 8bc2 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8bc2 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]