8bpg - Revision history

OCA at 09:29, 17 October 2024

2024-10-17T09:29:38Z

← Older revision		Revision as of 09:29, 17 October 2024
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bpg OCA], [https://pdbe.org/8bpg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bpg RCSB], [https://www.ebi.ac.uk/pdbsum/8bpg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bpg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bpg OCA], [https://pdbe.org/8bpg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bpg RCSB], [https://www.ebi.ac.uk/pdbsum/8bpg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bpg ProSAT]</span></td></tr>
	</table>		</table>
	== ~~Function~~ ==		<div style="background-color:#fffaf0;">
	~~[https://www.uniprot.org/uniprot/FAIM3_HUMAN FAIM3_HUMAN] May~~ play ~~a role~~ in ~~the~~ immune ~~system processes~~. ~~Protects~~ cells ~~from FAS-~~, ~~TNF alpha-~~ and ~~FADD-induced apoptosis without increasing expression~~ of the ~~inhibitors~~ of ~~apoptosis BCL2~~ and ~~BCLXL~~. ~~Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation~~, ~~rather than blocking apoptotic signals downstream~~. ~~May inhibit FAS~~-~~induced apoptosis by preventing CASP8 processing through CFLAR up~~-~~regulation~~.<ref>PMID:~~9586636~~</ref>		== Publication Abstract from PubMed ==
			Immunoglobulin Fc receptors are cell surface transmembrane proteins that bind to the Fc constant region of antibodies and play critical roles in regulating immune responses by activation of immune cells, clearance of immune complexes and regulation of antibody production. FcmuR is the immunoglobulin M (IgM) antibody isotype-specific Fc receptor involved in the survival and activation of B cells. Here we reveal eight binding sites for the human FcmuR immunoglobulin domain on the IgM pentamer by cryogenic electron microscopy. One of the sites overlaps with the binding site for the polymeric immunoglobulin receptor (pIgR), but a different mode of FcmuR binding explains its antibody isotype specificity. Variation in FcmuR binding sites and their occupancy reflects the asymmetry of the IgM pentameric core and the versatility of FcmuR binding. The complex explains engagement with polymeric serum IgM and the monomeric IgM B-cell receptor (BCR).

			Structural basis for Fc receptor recognition of immunoglobulin M.,Chen Q, Menon RP, Masino L, Tolar P, Rosenthal PB Nat Struct Mol Biol. 2023 Jul;30(7):1033-1039. doi: 10.1038/s41594-023-00985-x. , Epub 2023 Apr 24. PMID:37095205<ref>PMID:37095205</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 8bpg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:51, 26 July 2023

2023-07-26T12:51:33Z

← Older revision		Revision as of 12:51, 26 July 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8bpg]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BPG FirstGlance]. <br>		<table><tr><td colspan='2'>[[8bpg]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BPG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.1Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bpg OCA], [https://pdbe.org/8bpg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bpg RCSB], [https://www.ebi.ac.uk/pdbsum/8bpg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bpg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bpg OCA], [https://pdbe.org/8bpg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bpg RCSB], [https://www.ebi.ac.uk/pdbsum/8bpg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bpg ProSAT]</span></td></tr>
	</table>		</table>

OCA at 20:30, 12 April 2023

2023-04-12T20:30:32Z

← Older revision		Revision as of 20:30, 12 April 2023
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8bpg is ~~ON HOLD until Paper Publication~~		==FcMR binding at subunit Fcu3 of IgM pentamer==
			<StructureSection load='8bpg' size='340' side='right'caption='[[8bpg]], [[Resolution\|resolution]] 3.10Å' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>[[8bpg]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BPG FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bpg OCA], [https://pdbe.org/8bpg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bpg RCSB], [https://www.ebi.ac.uk/pdbsum/8bpg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bpg ProSAT]</span></td></tr>
			</table>
			== Function ==
			[https://www.uniprot.org/uniprot/FAIM3_HUMAN FAIM3_HUMAN] May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.<ref>PMID:9586636</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Chen Q]]
			[[Category: Rosenthal P]]
			[[Category: Tolar P]]

OCA at 05:26, 28 December 2022

2022-12-28T05:26:12Z

← Older revision		Revision as of 05:26, 28 December 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8bpg is ON HOLD		The entry 8bpg is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8bpg" [edit=sysop:move=sysop]

2022-11-24T08:05:32Z

Protected "8bpg" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:05, 24 November 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8bpg is ON HOLD Authors: Description: Category: Unreleased Structures

2022-11-24T08:05:31Z

New page: '''Unreleased structure''' The entry 8bpg is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8bpg is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]