8c8a - Revision history

OCA at 05:51, 4 September 2024

2024-09-04T05:51:43Z

← Older revision		Revision as of 05:51, 4 September 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8c8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyricularia_oryzae_70-15 Pyricularia oryzae 70-15]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[8c8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyricularia_oryzae_70-15 Pyricularia oryzae 70-15]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C8A FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c8a OCA], [https://pdbe.org/8c8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c8a RCSB], [https://www.ebi.ac.uk/pdbsum/8c8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c8a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c8a OCA], [https://pdbe.org/8c8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c8a RCSB], [https://www.ebi.ac.uk/pdbsum/8c8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c8a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/G4MW19_PYRO7 G4MW19_PYRO7]		[https://www.uniprot.org/uniprot/G4MW19_PYRO7 G4MW19_PYRO7]
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Magnaporthe AVRs and ToxB-like (MAX) effectors constitute a family of secreted virulence proteins in the fungus Pyricularia oryzae (syn. Magnaporthe oryzae), which causes blast disease on numerous cereals and grasses. In spite of high sequence divergence, MAX effectors share a common fold characterized by a ss-sandwich core stabilized by a conserved disulfide bond. In this study, we investigated the structural landscape and diversity within the MAX effector repertoire of P. oryzae. Combining experimental protein structure determination and in silico structure modeling we validated the presence of the conserved MAX effector core domain in 77 out of 94 groups of orthologs (OG) identified in a previous population genomic study. Four novel MAX effector structures determined by NMR were in remarkably good agreement with AlphaFold2 (AF2) predictions. Based on the comparison of the AF2-generated 3D models we propose a classification of the MAX effectors superfamily in 20 structural groups that vary in the canonical MAX fold, disulfide bond patterns, and additional secondary structures in N- and C-terminal extensions. About one-third of the MAX family members remain singletons, without strong structural relationship to other MAX effectors. Analysis of the surface properties of the AF2 MAX models also highlights the high variability within the MAX family at the structural level, potentially reflecting the wide diversity of their virulence functions and host targets.

			The structural landscape and diversity of Pyricularia oryzae MAX effectors revisited.,Lahfa M, Barthe P, de Guillen K, Cesari S, Raji M, Kroj T, Le Naour-Vernet M, Hoh F, Gladieux P, Roumestand C, Gracy J, Declerck N, Padilla A PLoS Pathog. 2024 May 6;20(5):e1012176. doi: 10.1371/journal.ppat.1012176. , eCollection 2024 May. PMID:38709846<ref>PMID:38709846</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 8c8a" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:18, 14 February 2024

2024-02-14T07:18:52Z

← Older revision		Revision as of 07:18, 14 February 2024
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	~~'''Unreleased structure'''~~

	The ~~entry~~ 8c8a is ~~ON HOLD until Paper Publication~~		==The NMR structure of the MAX28 effector from Magnaporthe oryzae==
			<StructureSection load='8c8a' size='340' side='right'caption='[[8c8a]]' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>[[8c8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyricularia_oryzae_70-15 Pyricularia oryzae 70-15]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C8A FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c8a OCA], [https://pdbe.org/8c8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c8a RCSB], [https://www.ebi.ac.uk/pdbsum/8c8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c8a ProSAT]</span></td></tr>
			</table>
			== Function ==
			[https://www.uniprot.org/uniprot/G4MW19_PYRO7 G4MW19_PYRO7]
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Pyricularia oryzae 70-15]]
			[[Category: Barthe P]]
			[[Category: Kroj T]]
			[[Category: Lahfa M]]
			[[Category: Padilla A]]
			[[Category: Roumestand C]]
			[[Category: De Guillen K]]

OCA at 04:57, 8 February 2023

2023-02-08T04:57:09Z

← Older revision		Revision as of 04:57, 8 February 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8c8a is ON HOLD		The entry 8c8a is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 09:09, 1 February 2023

2023-02-01T09:09:12Z

← Older revision		Revision as of 09:09, 1 February 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8c8a is ON HOLD ~~until Paper Publication~~		The entry 8c8a is ON HOLD

	Authors:		Authors:

OCA: Protected "8c8a" [edit=sysop:move=sysop]

2023-01-25T04:53:54Z

Protected "8c8a" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:53, 25 January 2023
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8c8a is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2023-01-25T04:53:52Z

New page: '''Unreleased structure''' The entry 8c8a is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8c8a is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]