8cel - Revision history

OCA at 11:09, 11 February 2016

2016-02-11T11:09:53Z

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			{{Theoretical_model}}

	==THEORETICAL MODEL OF CBH1 IN COMPLEX WITH A CELLULOSE NANOMER==		==THEORETICAL MODEL OF CBH1 IN COMPLEX WITH A CELLULOSE NANOMER==
	<StructureSection load='8cel' size='340' side='right' caption='[[8cel]]' scene=''>		<StructureSection load='8cel' size='340' side='right' caption='[[8cel]]' scene=''>
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 8cel" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Theoretical Model]]
	[[Category: Divne, C]]		[[Category: Divne, C]]
	[[Category: Jones, T A]]		[[Category: Jones, T A]]
	[[Category: Stahlberg, J]]		[[Category: Stahlberg, J]]

OCA at 17:03, 10 December 2014

2014-12-10T17:03:23Z

← Older revision		Revision as of 17:03, 10 December 2014
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	~~{{Theoretical_model}}~~		==THEORETICAL MODEL OF CBH1 IN COMPLEX WITH A CELLULOSE NANOMER==
			<StructureSection load='8cel' size='340' side='right' caption='[[8cel]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=8CEL FirstGlance]. <br>
			</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=8cel FirstGlance], [http://www.ebi.ac.uk/pdbsum/8cel PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Detailed information has been obtained, by means of protein X-ray crystallography, on how a cellulose chain is bound in the cellulose-binding tunnel of cellobiohydrolase I (CBHI), the major cellulase in the hydrolysis of native, crystalline cellulose by the fungus Trichoderma reesei. Three high-resolution crystal structures of different catalytically deficient mutants of CBHI in complex with cellotetraose, cellopentaose and cellohexaose have been refined at 1.9, 1.7 and 1.9 A resolution, respectively. The observed binding of cellooligomers in the tunnel allowed unambiguous identification of ten well-defined subsites for glucosyl units that span a length of approximately 50 A. All bound oligomers have the same directionality and orientation, and the positions of the glucosyl units in each binding site agree remarkably well between the different complexes. The binding mode observed here corresponds to that expected during productive binding of a cellulose chain. The structures support the hypothesis that hydrolysis by CBHI proceeds from the reducing towards the non-reducing end of a cellulose chain, and they provide a structural explanation for the observed distribution of initial hydrolysis products.

	~~[[Image~~:~~8cel~~.~~png\|left\|200px]]~~		High-resolution crystal structures reveal how a cellulose chain is bound in the 50 A long tunnel of cellobiohydrolase I from Trichoderma reesei.,Divne C, Stahlberg J, Teeri TT, Jones TA J Mol Biol. 1998 Jan 16;275(2):309-25. PMID:9466911<ref>PMID:9466911</ref>

	~~{{STRUCTURE_8cel\| PDB=8cel \| SCENE= }}~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~===THEORETICAL MODEL OF CBH1 IN COMPLEX WITH A CELLULOSE NANOMER===~~		== References ==
			<references/>
	~~{{ABSTRACT_PUBMED_9466911}}~~		__TOC__
			</StructureSection>
	==~~Reference~~==
	<~~ref group="xtra">PMID:009466911<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Divne, C]]		[[Category: Divne, C]]
	[[Category: Jones, T A]]		[[Category: Jones, T A]]
	[[Category: Stahlberg, J]]		[[Category: Stahlberg, J]]

OCA: Protected "8cel" [edit=sysop:move=sysop]

2012-10-21T10:05:09Z

Protected "8cel" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:05, 21 October 2012
(No difference)

OCA at 10:05, 21 October 2012

2012-10-21T10:05:04Z

← Older revision		Revision as of 10:05, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
	~~{{Seed}}~~
	[[Image:8cel.png\|left\|200px]]		[[Image:8cel.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_8cel", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
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	{{STRUCTURE_8cel\| PDB=8cel \| SCENE= }}		{{STRUCTURE_8cel\| PDB=8cel \| SCENE= }}

	===THEORETICAL MODEL OF CBH1 IN COMPLEX WITH A CELLULOSE NANOMER===		===THEORETICAL MODEL OF CBH1 IN COMPLEX WITH A CELLULOSE NANOMER===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_9466911}}, adds the Publication Abstract to the page~~
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	{{ABSTRACT_PUBMED_9466911}}		{{ABSTRACT_PUBMED_9466911}}

	~~==About this Structure==~~
	~~Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CEL OCA].~~

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~9466911~~</ref><references group="xtra"/>		<ref group="xtra">PMID:009466911</ref><references group="xtra"/>
	[[Category: Divne, C]]		[[Category: Divne, C]]
	[[Category: Jones, T A]]		[[Category: Jones, T A]]
	[[Category: Stahlberg, J]]		[[Category: Stahlberg, J]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 7 21:12:29 2010''~~

OCA at 18:12, 7 April 2010

2010-04-07T18:12:29Z

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OCA at 06:58, 30 July 2008

2008-07-30T06:58:58Z

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	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul ~~23 13~~:33:52 2008''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 30 09:58:57 2008''

OCA: New page: '''Theoretical Model''' The entry 8CEL is a Theoretical Model titled 'THEORETICAL MODEL OF CBH1 IN COMPLEX WITH A CELLULOSE NANOMER'. Category:Theoretical Model ''Page seeded by [h...

2008-07-23T10:33:53Z

New page: '''Theoretical Model''' The entry 8CEL is a Theoretical Model titled 'THEORETICAL MODEL OF CBH1 IN COMPLEX WITH A CELLULOSE NANOMER'. Category:Theoretical Model ''Page seeded by [h...

New page

'''Theoretical Model'''

The entry 8CEL is a Theoretical Model titled 'THEORETICAL MODEL OF CBH1 IN COMPLEX WITH A CELLULOSE NANOMER'.

[[Category:Theoretical Model]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 13:33:52 2008''