8d64 - Revision history

OCA at 05:19, 12 June 2024

2024-06-12T05:19:32Z

← Older revision		Revision as of 05:19, 12 June 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8d64]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Dickeya_dadantii Dickeya dadantii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D64 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8d64]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Dickeya_dadantii Dickeya dadantii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D64 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DHL:2-AMINO-ETHANETHIOL'>DHL</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.14Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DHL:2-AMINO-ETHANETHIOL'>DHL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d64 OCA], [https://pdbe.org/8d64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d64 RCSB], [https://www.ebi.ac.uk/pdbsum/8d64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d64 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d64 OCA], [https://pdbe.org/8d64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d64 RCSB], [https://www.ebi.ac.uk/pdbsum/8d64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d64 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/E0SJQ4_DICD3 E0SJQ4_DICD3]		[https://www.uniprot.org/uniprot/E0SJQ4_DICD3 E0SJQ4_DICD3]
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Pentameric ligand-gated ion channels (pLGICs) mediate synaptic transmission and are sensitive to their lipid environment. The mechanism of phospholipid modulation of any pLGIC is not well understood. We demonstrate that the model pLGIC, ELIC (Erwinia ligand-gated ion channel), is positively modulated by the anionic phospholipid, phosphatidylglycerol, from the outer leaflet of the membrane. To explore the mechanism of phosphatidylglycerol modulation, we determine a structure of ELIC in an open-channel conformation. The structure shows a bound phospholipid in an outer leaflet site, and structural changes in the phospholipid binding site unique to the open-channel. In combination with streamlined alchemical free energy perturbation calculations and functional measurements in asymmetric liposomes, the data support a mechanism by which an anionic phospholipid stabilizes the activated, open-channel state of a pLGIC by specific, state-dependent binding to this site.

			Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation.,Petroff JT 2nd, Dietzen NM, Santiago-McRae E, Deng B, Washington MS, Chen LJ, Trent Moreland K, Deng Z, Rau M, Fitzpatrick JAJ, Yuan P, Joseph TT, Henin J, Brannigan G, Cheng WWL Nat Commun. 2022 Nov 17;13(1):7017. doi: 10.1038/s41467-022-34813-5. PMID:36385237<ref>PMID:36385237</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 8d64" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Ion channels 3D structures\|Ion channels 3D structures]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:15, 24 November 2022

2022-11-24T10:15:00Z

← Older revision		Revision as of 10:15, 24 November 2022
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8d64 is ~~ON HOLD until Paper Publication~~		==ELIC with cysteamine in POPC nanodisc==
			<StructureSection load='8d64' size='340' side='right'caption='[[8d64]], [[Resolution\|resolution]] 3.14Å' scene=''>
	~~Authors~~: ~~Petroff II~~, J.T., ~~Deng~~, Z.~~, Rau, M~~.J., ~~Fitzpatrick, J~~.A.J., ~~Yuan, P~~.~~, Cheng, W~~.W.L.		== Structural highlights ==
			<table><tr><td colspan='2'>[[8d64]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Dickeya_dadantii Dickeya dadantii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D64 FirstGlance]. <br>
	~~Description~~: ~~ELIC with cysteamine in POPC nanodisc~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DHL:2-AMINO-ETHANETHIOL'>DHL</scene></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d64 OCA], [https://pdbe.org/8d64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d64 RCSB], [https://www.ebi.ac.uk/pdbsum/8d64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d64 ProSAT]</span></td></tr>
	[[Category: Cheng~~, W.W.L~~]]		</table>
	[[Category: ~~Fitzpatrick, J.A.J~~]]		== Function ==
	[[Category: ~~Yuan, P~~]]		[https://www.uniprot.org/uniprot/E0SJQ4_DICD3 E0SJQ4_DICD3]
	[[Category: ~~Rau, M.J~~]]		__TOC__
	[[Category: ~~Deng, Z~~]]		</StructureSection>
	[[Category: ~~Petroff Ii, J.T~~]]		[[Category: Dickeya dadantii]]
			[[Category: Large Structures]]
			[[Category: Cheng WWL]]
			[[Category: Deng Z]]
			[[Category: Fitzpatrick JAJ]]
			[[Category: Petroff II JT]]
			[[Category: Rau MJ]]
			[[Category: Yuan P]]

OCA at 03:56, 26 October 2022

2022-10-26T03:56:11Z

← Older revision		Revision as of 03:56, 26 October 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8d64 is ON HOLD		The entry 8d64 is ON HOLD until Paper Publication

	Authors: Petroff II, J.T., Deng, Z., Rau, M.J., Fitzpatrick, J.A.J., Yuan, P., Cheng, W.W.L.		Authors: Petroff II, J.T., Deng, Z., Rau, M.J., Fitzpatrick, J.A.J., Yuan, P., Cheng, W.W.L.
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Cheng, W.W.L]]		[[Category: Cheng, W.W.L]]
			[[Category: Fitzpatrick, J.A.J]]
	[[Category: Yuan, P]]		[[Category: Yuan, P]]
	[[Category: Rau, M.J]]		[[Category: Rau, M.J]]
	~~[[Category: Fitzpatrick, J.A.J]]~~
	[[Category: Deng, Z]]		[[Category: Deng, Z]]
	[[Category: Petroff Ii, J.T]]		[[Category: Petroff Ii, J.T]]

OCA at 04:38, 28 September 2022

2022-09-28T04:38:42Z

← Older revision		Revision as of 04:38, 28 September 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8d64 is ON HOLD ~~until Paper Publication~~		The entry 8d64 is ON HOLD

	Authors: Petroff II, J.T., Deng, Z., Rau, M.J., Fitzpatrick, J.A.J., Yuan, P., Cheng, W.W.L.		Authors: Petroff II, J.T., Deng, Z., Rau, M.J., Fitzpatrick, J.A.J., Yuan, P., Cheng, W.W.L.

OCA at 04:13, 13 July 2022

2022-07-13T04:13:29Z

← Older revision		Revision as of 04:13, 13 July 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8d64 is ON HOLD		The entry 8d64 is ON HOLD until Paper Publication

	Authors: Petroff II, J.T., Deng, Z., Rau, M.J., Fitzpatrick, J.A.J., Yuan, P., Cheng, W.W.L.		Authors: Petroff II, J.T., Deng, Z., Rau, M.J., Fitzpatrick, J.A.J., Yuan, P., Cheng, W.W.L.
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Cheng, W.W.L]]		[[Category: Cheng, W.W.L]]
	~~[[Category: Fitzpatrick, J.A.J]]~~
	[[Category: Yuan, P]]		[[Category: Yuan, P]]
	[[Category: Rau, M.J]]		[[Category: Rau, M.J]]
			[[Category: Fitzpatrick, J.A.J]]
	[[Category: Deng, Z]]		[[Category: Deng, Z]]
	[[Category: Petroff Ii, J.T]]		[[Category: Petroff Ii, J.T]]

OCA: Protected "8d64" [edit=sysop:move=sysop]

2022-06-15T04:11:51Z

Protected "8d64" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:11, 15 June 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8d64 is ON HOLD Authors: Petroff II, J.T., Deng, Z., Rau, M.J., Fitzpatrick, J.A.J., Yuan, P., Cheng, W.W.L. Description: ELIC with cysteamine in P...

2022-06-15T04:11:50Z

New page: '''Unreleased structure''' The entry 8d64 is ON HOLD Authors: Petroff II, J.T., Deng, Z., Rau, M.J., Fitzpatrick, J.A.J., Yuan, P., Cheng, W.W.L. Description: ELIC with cysteamine in P...

New page

'''Unreleased structure'''

The entry 8d64 is ON HOLD

Authors: Petroff II, J.T., Deng, Z., Rau, M.J., Fitzpatrick, J.A.J., Yuan, P., Cheng, W.W.L.

Description: ELIC with cysteamine in POPC nanodisc
[[Category: Unreleased Structures]]
[[Category: Cheng, W.W.L]]
[[Category: Fitzpatrick, J.A.J]]
[[Category: Yuan, P]]
[[Category: Rau, M.J]]
[[Category: Deng, Z]]
[[Category: Petroff Ii, J.T]]