8dbe - Revision history

OCA at 05:20, 12 June 2024

2024-06-12T05:20:32Z

← Older revision		Revision as of 05:20, 12 June 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8dbe]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DBE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DBE FirstGlance]. <br>		<table><tr><td colspan='2'>[[8dbe]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DBE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DBE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=HSX:5-O-PHOSPHONO-ALPHA-D-RIBOFURANOSE'>HSX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.1Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=HSX:5-O-PHOSPHONO-ALPHA-D-RIBOFURANOSE'>HSX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dbe OCA], [https://pdbe.org/8dbe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dbe RCSB], [https://www.ebi.ac.uk/pdbsum/8dbe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dbe ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dbe OCA], [https://pdbe.org/8dbe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dbe RCSB], [https://www.ebi.ac.uk/pdbsum/8dbe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dbe ProSAT]</span></td></tr>
	</table>		</table>
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/PRPS1_HUMAN PRPS1_HUMAN] Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.		[https://www.uniprot.org/uniprot/PRPS1_HUMAN PRPS1_HUMAN] Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The universally conserved enzyme phosphoribosyl pyrophosphate synthetase (PRPS) assembles filaments in evolutionarily diverse organisms. PRPS is a key regulator of nucleotide metabolism, and mutations in the human enzyme PRPS1 lead to a spectrum of diseases. Here we determine structures of human PRPS1 filaments in active and inhibited states, with fixed assembly contacts accommodating both conformations. The conserved assembly interface stabilizes the binding site for the essential activator phosphate, increasing activity in the filament. Some disease mutations alter assembly, supporting the link between filament stability and activity. Structures of active PRPS1 filaments turning over substrate also reveal coupling of catalysis in one active site with product release in an adjacent site. PRPS1 filaments therefore provide an additional layer of allosteric control, conserved throughout evolution, with likely impact on metabolic homeostasis. Stabilization of allosteric binding sites by polymerization adds to the growing diversity of assembly-based enzyme regulatory mechanisms.

			Human PRPS1 filaments stabilize allosteric sites to regulate activity.,Hvorecny KL, Hargett K, Quispe JD, Kollman JM Nat Struct Mol Biol. 2023 Mar;30(3):391-402. doi: 10.1038/s41594-023-00921-z. , Epub 2023 Feb 6. PMID:36747094<ref>PMID:36747094</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 8dbe" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:27, 15 February 2023

2023-02-15T10:27:25Z

← Older revision		Revision as of 10:27, 15 February 2023
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	~~'''Unreleased structure'''~~

	~~The~~ entry ~~8dbe~~ is ~~ON HOLD~~ ~~until Paper Publication~~		==Human PRPS1 with ADP; Hexamer==
			<StructureSection load='8dbe' size='340' side='right'caption='[[8dbe]], [[Resolution\|resolution]] 2.10Å' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>[[8dbe]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DBE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DBE FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=HSX:5-O-PHOSPHONO-ALPHA-D-RIBOFURANOSE'>HSX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dbe OCA], [https://pdbe.org/8dbe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dbe RCSB], [https://www.ebi.ac.uk/pdbsum/8dbe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dbe ProSAT]</span></td></tr>
			</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/PRPS1_HUMAN PRPS1_HUMAN] Defects in PRPS1 are the cause of phosphoribosylpyrophosphate synthetase superactivity (PRPS1 superactivity) [MIM:[https://omim.org/entry/300661 300661]; also known as PRPS-related gout. It is a familial disorder characterized by excessive purine production, gout and uric acid urolithiasis. Defects in PRPS1 are the cause of Charcot-Marie-Tooth disease X-linked recessive type 5 (CMTX5) [MIM:[https://omim.org/entry/311070 311070]; also known as optic atrophy-polyneuropathy-deafness or Rosenberg-Chutorian syndrome. CMTX5 is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies characterized by severely reduced motor nerve conduction velocities (NCVs) (less than 38m/s) and segmental demyelination and remyelination, and primary peripheral axonal neuropathies characterized by normal or mildly reduced NCVs and chronic axonal degeneration and regeneration on nerve biopsy.<ref>PMID:17701900</ref> Defects in PRPS1 are the cause of ARTS syndrome (ARTS) [MIM:[https://omim.org/entry/301835 301835]; also known as fatal ataxia X-linked with deafness and loss of vision. ARTS is a disorder characterized by mental retardation, early-onset hypotonia, ataxia, delayed motor development, hearing impairment, and optic atrophy. Susceptibility to infections, especially of the upper respiratory tract, can result in early death.<ref>PMID:17701896</ref> Defects in PRPS1 are the cause of deafness X-linked type 1 (DFNX1) [MIM:[https://omim.org/entry/304500 304500]; also known as congenital sensorineural deafness X-linked 2 (DFN2). It is a form of deafness characterized by progressive, severe-to-profound sensorineural hearing loss in males. Females manifest mild to moderate hearing loss.<ref>PMID:20021999</ref>
			== Function ==
			[https://www.uniprot.org/uniprot/PRPS1_HUMAN PRPS1_HUMAN] Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Hvorecny KL]]
			[[Category: Kollman JM]]

OCA at 04:39, 28 September 2022

2022-09-28T04:39:01Z

← Older revision		Revision as of 04:39, 28 September 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8dbe is ON HOLD		The entry 8dbe is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 15:29, 7 September 2022

2022-09-07T15:29:09Z

← Older revision		Revision as of 15:29, 7 September 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8dbe is ON HOLD ~~until Paper Publication~~		The entry 8dbe is ON HOLD

	Authors:		Authors:

OCA at 04:24, 20 July 2022

2022-07-20T04:24:28Z

← Older revision		Revision as of 04:24, 20 July 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8dbe is ON HOLD		The entry 8dbe is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8dbe" [edit=sysop:move=sysop]

2022-06-22T07:29:28Z

Protected "8dbe" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:29, 22 June 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8dbe is ON HOLD Authors: Description: Category: Unreleased Structures

2022-06-22T07:29:27Z

New page: '''Unreleased structure''' The entry 8dbe is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8dbe is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]