8dn2 - Revision history

OCA at 07:09, 21 November 2024

2024-11-21T07:09:57Z

← Older revision		Revision as of 07:09, 21 November 2024
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/GLRA1_HUMAN GLRA1_HUMAN] The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).		[https://www.uniprot.org/uniprot/GLRA1_HUMAN GLRA1_HUMAN] The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Hetero-pentameric Cys-loop receptors constitute a major type of neurotransmitter receptors that enable signal transmission and processing in the nervous system. Despite intense investigations into their working mechanism and pharmaceutical potentials, how neurotransmitters activate these receptors remains unclear due to the lack of high-resolution structural information in the activated open state. Here we report near-atomic resolution structures resolved in digitonin consistent with all principle functional states of the human alpha1beta GlyR, which is a major Cys-loop receptor that mediates inhibitory neurotransmission in the central nervous system of adults. Glycine binding induces cooperative and symmetric structural rearrangements in the neurotransmitter-binding extracellular domain but asymmetrical pore dilation in the transmembrane domain. Symmetric response in the extracellular domain is consistent with electrophysiological data showing cooperative glycine activation and contribution from both alpha1 and beta subunits. A set of functionally essential but differentially charged amino acid residues in the transmembrane domain of the alpha1 and beta subunits explains asymmetric activation. These findings provide a foundation for understanding how the gating of the Cys-loop receptor family members diverges to accommodate specific physiological environments.

			Asymmetric gating of a human hetero-pentameric glycine receptor.,Liu X, Wang W Nat Commun. 2023 Oct 11;14(1):6377. doi: 10.1038/s41467-023-42051-6. PMID:37821459<ref>PMID:37821459</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 8dn2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:56, 11 October 2023

2023-10-11T05:56:21Z

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-The entry 8dn2 is ON HOLD  until Paper Publication
+==Cryo-EM structure of human Glycine Receptor alpha1-beta heteromer, glycine-bound state 2(expanded open)==
+<StructureSection load='8dn2' size='340' side='right'caption='[[8dn2]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8dn2]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DN2 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D10:DECANE'>D10</scene>, <scene name='pdbligand=DD9:NONANE'>DD9</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=HEX:HEXANE'>HEX</scene>, <scene name='pdbligand=HP6:HEPTANE'>HP6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NBU:N-BUTANE'>NBU</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=UND:UNDECANE'>UND</scene></td></tr>

OCA at 10:38, 26 July 2023

2023-07-26T10:38:27Z

← Older revision		Revision as of 10:38, 26 July 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8dn2 is ON HOLD		The entry 8dn2 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 04:34, 19 July 2023

2023-07-19T04:34:56Z

← Older revision		Revision as of 04:34, 19 July 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8dn2 is ON HOLD ~~until Paper Publication~~		The entry 8dn2 is ON HOLD

	Authors:		Authors:

OCA at 03:47, 12 July 2023

2023-07-12T03:47:42Z

← Older revision		Revision as of 03:47, 12 July 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8dn2 is ON HOLD		The entry 8dn2 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8dn2" [edit=sysop:move=sysop]

2022-07-20T04:30:53Z

Protected "8dn2" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:30, 20 July 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8dn2 is ON HOLD Authors: Description: Category: Unreleased Structures

2022-07-20T04:30:51Z

New page: '''Unreleased structure''' The entry 8dn2 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8dn2 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]