8dqa - Revision history

OCA at 07:35, 3 July 2024

2024-07-03T07:35:22Z

← Older revision		Revision as of 07:35, 3 July 2024
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	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/~~Q9SCU2_ARATH Q9SCU2_ARATH~~]		[https://www.uniprot.org/uniprot/Q8LG92_ARATH Q8LG92_ARATH]
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Mammalian macrophage migration inhibitory factor (MIF) and its paralog, D-dopachrome tautomerase, are multifunctional inflammatory cytokines. Plants have orthologous MIF and D-dopachrome tautomerase-like (MDL) proteins that mimic some of the effects of MIF on immune cells in vitro. We explored the structural and functional similarities between the three Arabidopsis thaliana MDLs and MIF. X-ray crystallography of the MDLs revealed high structural similarity between MDL and MIF homotrimers and suggested a potential explanation for the lack of tautomerase activity in the MDLs. MDL1 and MDL2 interacted with each other and with MIF in vitro, in yeast, and in plant leaves and formed hetero-oligomeric complexes with MIF in vitro. The MDLs stimulated signaling through the MIF receptors CXCR2 or CXCR4 and enhanced the responses to MIF in a yeast reporter system, in human neutrophils, and in human lung epithelial cells. Pharmacological inhibitors that disrupted MIF activity or prevented the formation of MIF-MDL hetero-oligomers blocked the observed synergism. These findings demonstrate that MDLs can enhance cellular responses to MIF, which may have functional implications in tissues exposed to MDLs from the diet or environment.

			Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells.,Spiller L, Manjula R, Leissing F, Basquin J, Bourilhon P, Sinitski D, Brandhofer M, Levecque S, Gerra S, Sabelleck B, Zhang L, Feederle R, Flatley A, Hoffmann A, Panstruga R, Bernhagen J, Lolis E Sci Signal. 2023 Nov 21;16(812):eadg2621. doi: 10.1126/scisignal.adg2621. Epub , 2023 Nov 21. PMID:37988455<ref>PMID:37988455</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 8dqa" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:37, 26 July 2023

2023-07-26T12:37:19Z

← Older revision		Revision as of 12:37, 26 July 2023
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8dqa is ~~ON HOLD until Paper Publication~~		==Structure of A. thaliana MIF/D-DT-like protein-3 (MDL3)==
			<StructureSection load='8dqa' size='340' side='right'caption='[[8dqa]], [[Resolution\|resolution]] 2.00Å' scene=''>
	~~Authors~~: ~~Manjula~~, R., ~~Basquin~~, J., ~~Lolis~~, E.		== Structural highlights ==
			<table><tr><td colspan='2'>[[8dqa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DQA FirstGlance]. <br>
	~~Description~~: ~~Structure of A~~. thaliana ~~MIF/D-DT-like protein-3 (MDL3)~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dqa OCA], [https://pdbe.org/8dqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dqa RCSB], [https://www.ebi.ac.uk/pdbsum/8dqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dqa ProSAT]</span></td></tr>
	[[Category: ~~Manjula, R~~]]		</table>
	[[Category: Lolis, E]]		== Function ==
	[[Category: ~~Basquin, J~~]]		[https://www.uniprot.org/uniprot/Q9SCU2_ARATH Q9SCU2_ARATH]
			__TOC__
			</StructureSection>
			[[Category: Arabidopsis thaliana]]
			[[Category: Large Structures]]
			[[Category: Basquin J]]
			[[Category: Lolis E]]
			[[Category: Manjula R]]

OCA at 17:05, 19 October 2022

2022-10-19T17:05:54Z

← Older revision		Revision as of 17:05, 19 October 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8dqa is ON HOLD		The entry 8dqa is ON HOLD until Paper Publication

	Authors: Manjula, R., Basquin, J., Lolis, E.		Authors: Manjula, R., Basquin, J., Lolis, E.

OCA at 06:33, 21 September 2022

2022-09-21T06:33:10Z

← Older revision		Revision as of 06:33, 21 September 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8dqa is ON HOLD ~~until Paper Publication~~		The entry 8dqa is ON HOLD

	Authors: Manjula, R., ~~Baskin~~, J., Lolis, E.		Authors: Manjula, R., Basquin, J., Lolis, E.

	Description: Structure of A. thaliana MIF/D-DT-like protein-3 (MDL3)		Description: Structure of A. thaliana MIF/D-DT-like protein-3 (MDL3)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	~~[[Category: Baskin, J]]~~
	[[Category: Manjula, R]]		[[Category: Manjula, R]]
	[[Category: Lolis, E]]		[[Category: Lolis, E]]
			[[Category: Basquin, J]]

OCA at 03:48, 25 August 2022

2022-08-25T03:48:30Z

← Older revision		Revision as of 03:48, 25 August 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8dqa is ON HOLD		The entry 8dqa is ON HOLD until Paper Publication

	Authors: Manjula, R., Baskin, J., Lolis, E.		Authors: Manjula, R., Baskin, J., Lolis, E.

OCA: Protected "8dqa" [edit=sysop:move=sysop]

2022-07-27T16:46:19Z

Protected "8dqa" [edit=sysop:move=sysop]

← Older revision	Revision as of 16:46, 27 July 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8dqa is ON HOLD Authors: Manjula, R., Baskin, J., Lolis, E. Description: Structure of A. thaliana MIF/D-DT-like protein-3 (MDL3) [[Category: Unrele...

2022-07-27T16:46:18Z

New page: '''Unreleased structure''' The entry 8dqa is ON HOLD Authors: Manjula, R., Baskin, J., Lolis, E. Description: Structure of A. thaliana MIF/D-DT-like protein-3 (MDL3) [[Category: Unrele...

New page

'''Unreleased structure'''

The entry 8dqa is ON HOLD

Authors: Manjula, R., Baskin, J., Lolis, E.

Description: Structure of A. thaliana MIF/D-DT-like protein-3 (MDL3)
[[Category: Unreleased Structures]]
[[Category: Baskin, J]]
[[Category: Manjula, R]]
[[Category: Lolis, E]]