8dsa - Revision history

OCA at 05:53, 5 July 2023

2023-07-05T05:53:48Z

← Older revision		Revision as of 05:53, 5 July 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8dsa]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DSA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DSA FirstGlance]. <br>		<table><tr><td colspan='2'>[[8dsa]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DSA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DSA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.48Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dsa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dsa OCA], [https://pdbe.org/8dsa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dsa RCSB], [https://www.ebi.ac.uk/pdbsum/8dsa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dsa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dsa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dsa OCA], [https://pdbe.org/8dsa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dsa RCSB], [https://www.ebi.ac.uk/pdbsum/8dsa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dsa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/LRC8A_MOUSE LRC8A_MOUSE] Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Required for channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297).[UniProtKB:Q8IWT6]<ref>PMID:14660746</ref> <ref>PMID:24752297</ref> [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.		[https://www.uniprot.org/uniprot/LRC8A_MOUSE LRC8A_MOUSE] Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Required for channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297).[UniProtKB:Q8IWT6]<ref>PMID:14660746</ref> <ref>PMID:24752297</ref> [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.

			==See Also==
			*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:34, 8 March 2023

2023-03-08T07:34:57Z

← Older revision		Revision as of 07:34, 8 March 2023
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8dsa is ~~ON HOLD until Paper Publication~~		==LRRC8A:C in MSP1E3D1 nanodisc==
			<StructureSection load='8dsa' size='340' side='right'caption='[[8dsa]], [[Resolution\|resolution]] 3.48Å' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>[[8dsa]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DSA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DSA FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dsa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dsa OCA], [https://pdbe.org/8dsa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dsa RCSB], [https://www.ebi.ac.uk/pdbsum/8dsa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dsa ProSAT]</span></td></tr>
			</table>
			== Function ==
			[https://www.uniprot.org/uniprot/LRC8A_MOUSE LRC8A_MOUSE] Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Required for channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297).[UniProtKB:Q8IWT6]<ref>PMID:14660746</ref> <ref>PMID:24752297</ref> [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Mus musculus]]
			[[Category: Brohawn SG]]
			[[Category: Kern DM]]

OCA at 05:45, 11 January 2023

2023-01-11T05:45:37Z

← Older revision		Revision as of 05:45, 11 January 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8dsa is ON HOLD		The entry 8dsa is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 05:26, 7 December 2022

2022-12-07T05:26:17Z

← Older revision		Revision as of 05:26, 7 December 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8dsa is ON HOLD ~~until Paper Publication~~		The entry 8dsa is ON HOLD

	Authors:		Authors:

OCA at 03:49, 25 August 2022

2022-08-25T03:49:17Z

← Older revision		Revision as of 03:49, 25 August 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8dsa is ON HOLD		The entry 8dsa is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8dsa" [edit=sysop:move=sysop]

2022-07-27T16:49:38Z

Protected "8dsa" [edit=sysop:move=sysop]

← Older revision	Revision as of 16:49, 27 July 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8dsa is ON HOLD Authors: Description: Category: Unreleased Structures

2022-07-27T16:49:37Z

New page: '''Unreleased structure''' The entry 8dsa is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8dsa is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]