8dsg - Revision history

OCA at 15:04, 13 August 2026

2026-08-13T15:04:31Z

← Older revision		Revision as of 15:04, 13 August 2026
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	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/~~F2Q7T0_PRIMG F2Q7T0_PRIMG~~] Functions as a fatty acid monooxygenase.~~[PIRNR~~:~~PIRNR000209]~~		[https://www.uniprot.org/uniprot/CPXB_PRIM2 CPXB_PRIM2] Functions as a fatty acid monooxygenase (PubMed:11695892, PubMed:14653735, PubMed:16403573, PubMed:16566047, PubMed:17077084, PubMed:1727637, PubMed:17868686, PubMed:18004886, PubMed:18298086, PubMed:18619466, PubMed:18721129, PubMed:19492389, PubMed:20180779, PubMed:21110374, PubMed:21875028, PubMed:3106359, PubMed:7578081). Catalyzes hydroxylation of fatty acids at omega-1, omega-2 and omega-3 positions (PubMed:1727637, PubMed:21875028). Shows activity toward medium and long-chain fatty acids, with optimum chain lengths of 12, 14 and 16 carbons (lauric, myristic, and palmitic acids). Able to metabolize some of these primary metabolites to secondary and tertiary products (PubMed:1727637). Marginal activity towards short chain lengths of 8-10 carbons (PubMed:1727637, PubMed:18619466). Hydroxylates highly branched fatty acids, which play an essential role in membrane fluidity regulation (PubMed:16566047). Also displays a NADPH-dependent reductase activity in the C-terminal domain, which allows electron transfer from NADPH to the heme iron of the cytochrome P450 N-terminal domain (PubMed:11695892, PubMed:14653735, PubMed:16403573, PubMed:16566047, PubMed:17077084, PubMed:1727637, PubMed:17868686, PubMed:18004886, PubMed:18298086, PubMed:18619466, PubMed:18721129, PubMed:19492389, PubMed:20180779, PubMed:21110374, PubMed:21875028, PubMed:3106359, PubMed:7578081). Involved in inactivation of quorum sensing signals of other competing bacteria by oxidazing efficiently acyl homoserine lactones (AHLs), molecules involved in quorum sensing signaling pathways, and their lactonolysis products acyl homoserines (AHs) (PubMed:18020460).<ref>PMID:11695892</ref> <ref>PMID:14653735</ref> <ref>PMID:16403573</ref> <ref>PMID:16566047</ref> <ref>PMID:17077084</ref> <ref>PMID:1727637</ref> <ref>PMID:17868686</ref> <ref>PMID:18004886</ref> <ref>PMID:18020460</ref> <ref>PMID:18298086</ref> <ref>PMID:18619466</ref> <ref>PMID:18721129</ref> <ref>PMID:19492389</ref> <ref>PMID:20180779</ref> <ref>PMID:21110374</ref> <ref>PMID:21875028</ref> <ref>PMID:3106359</ref> <ref>PMID:7578081</ref>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:13, 25 October 2023

2023-10-25T10:13:55Z

← Older revision		Revision as of 10:13, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8dsg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium Priestia megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DSG FirstGlance]. <br>		<table><tr><td colspan='2'>[[8dsg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium Priestia megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DSG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.87Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dsg OCA], [https://pdbe.org/8dsg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dsg RCSB], [https://www.ebi.ac.uk/pdbsum/8dsg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dsg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dsg OCA], [https://pdbe.org/8dsg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dsg RCSB], [https://www.ebi.ac.uk/pdbsum/8dsg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dsg ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:35, 8 March 2023

2023-03-08T07:35:11Z

← Older revision		Revision as of 07:35, 8 March 2023
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8dsg is ~~ON HOLD until Paper Publication~~		==P411-PFA carbene transferase==
			<StructureSection load='8dsg' size='340' side='right'caption='[[8dsg]], [[Resolution\|resolution]] 1.87Å' scene=''>
	~~Authors~~: ~~Maggiolo~~, A.O., ~~Porter~~, N.J., ~~Zhang, J~~., ~~Arnold, F~~.H.		== Structural highlights ==
			<table><tr><td colspan='2'>[[8dsg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium Priestia megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DSG FirstGlance]. <br>
	~~Description~~: ~~P411-PFA carbene transferase~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dsg OCA], [https://pdbe.org/8dsg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dsg RCSB], [https://www.ebi.ac.uk/pdbsum/8dsg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dsg ProSAT]</span></td></tr>
	[[Category: ~~Maggiolo, A.O~~]]		</table>
	[[Category: Arnold~~, F.H~~]]		== Function ==
	[[Category: Porter~~, N.J~~]]		[https://www.uniprot.org/uniprot/F2Q7T0_PRIMG F2Q7T0_PRIMG] Functions as a fatty acid monooxygenase.[PIRNR:PIRNR000209]
	[[Category: Zhang, J]]		__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Priestia megaterium]]
			[[Category: Arnold FH]]
			[[Category: Maggiolo AO]]
			[[Category: Porter NJ]]
			[[Category: Zhang J]]

OCA at 04:02, 10 August 2022

2022-08-10T04:02:20Z

← Older revision		Revision as of 04:02, 10 August 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8dsg is ON HOLD		The entry 8dsg is ON HOLD until Paper Publication

	Authors: Maggiolo, A.O., Porter, N.J., Zhang, J., Arnold, F.H.		Authors: Maggiolo, A.O., Porter, N.J., Zhang, J., Arnold, F.H.

OCA: Protected "8dsg" [edit=sysop:move=sysop]

2022-08-03T03:54:59Z

Protected "8dsg" [edit=sysop:move=sysop]

← Older revision	Revision as of 03:54, 3 August 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8dsg is ON HOLD Authors: Maggiolo, A.O., Porter, N.J., Zhang, J., Arnold, F.H. Description: P411-PFA carbene transferase [[Category: Unreleased Str...

2022-08-03T03:54:58Z

New page: '''Unreleased structure''' The entry 8dsg is ON HOLD Authors: Maggiolo, A.O., Porter, N.J., Zhang, J., Arnold, F.H. Description: P411-PFA carbene transferase [[Category: Unreleased Str...

New page

'''Unreleased structure'''

The entry 8dsg is ON HOLD

Authors: Maggiolo, A.O., Porter, N.J., Zhang, J., Arnold, F.H.

Description: P411-PFA carbene transferase
[[Category: Unreleased Structures]]
[[Category: Maggiolo, A.O]]
[[Category: Arnold, F.H]]
[[Category: Porter, N.J]]
[[Category: Zhang, J]]