8dsv - Revision history

OCA at 09:33, 4 March 2026

2026-03-04T09:33:51Z

← Older revision		Revision as of 09:33, 4 March 2026
Line 5:		Line 5:
	<table><tr><td colspan='2'>[[8dsv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DSV FirstGlance]. <br>		<table><tr><td colspan='2'>[[8dsv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DSV FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=TXU:N-~~methylmyosmine~~'>TXU</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=TXU:3-(1-methyl-2,3-dihydropyrrol-5-yl)pyridine'>TXU</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dsv OCA], [https://pdbe.org/8dsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dsv RCSB], [https://www.ebi.ac.uk/pdbsum/8dsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dsv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dsv OCA], [https://pdbe.org/8dsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dsv RCSB], [https://www.ebi.ac.uk/pdbsum/8dsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dsv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/~~A0A7H5R8G3_PSEPU A0A7H5R8G3_PSEPU~~]		[https://www.uniprot.org/uniprot/NICA2_PSEP6 NICA2_PSEP6] Involved in nicotine degradation (PubMed:24204321, PubMed:26237398, PubMed:29812904, PubMed:33432238). Catalyzes the conversion of nicotine to N-methylmyosmine (PubMed:24204321, PubMed:29812904, PubMed:33432238, PubMed:33464876). N-methylmyosmine undergoes spontaneous hydrolysis to form pseudooxynicotine (PN) (PubMed:24204321). S-nicotine is the optimal substrate (PubMed:29812904). Has lower activity with some nicotine analogs, but shows no activity towards neurotransmitters, including serotonin, dopamine, and norepinephrine, nicotine metabolites and common neuroactive drugs (PubMed:29812904). The enzyme is stereospecific with poor activity with (R)-nicotine as the substrate (PubMed:29812904). The c-type cytochrome protein CycN is the physiological electron acceptor (PubMed:33432238). O(2) is a poor electron acceptor (PubMed:33432238, PubMed:33464876).<ref>PMID:24204321</ref> <ref>PMID:26237398</ref> <ref>PMID:29812904</ref> <ref>PMID:33432238</ref> <ref>PMID:33464876</ref>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:37, 26 July 2023

2023-07-26T12:37:24Z

← Older revision		Revision as of 12:37, 26 July 2023
Line 1:		Line 1:
	~~'''Unreleased structure'''~~

	The ~~entry~~ 8dsv is ~~ON HOLD until Paper Publication~~		==The structure of NicA2 in complex with N-methylmyosmine==
			<StructureSection load='8dsv' size='340' side='right'caption='[[8dsv]], [[Resolution\|resolution]] 2.50Å' scene=''>
	~~Authors~~: Wu, K., ~~Dulchavsky~~, M., Li, J., ~~Bardwell~~, J.C.A.		== Structural highlights ==
			<table><tr><td colspan='2'>[[8dsv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DSV FirstGlance]. <br>
	~~Description~~: ~~The structure of NicA2 in complex with N-methylmyosmine~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=TXU:N-methylmyosmine'>TXU</scene></td></tr>
	[[Category: ~~Li, J~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dsv OCA], [https://pdbe.org/8dsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dsv RCSB], [https://www.ebi.ac.uk/pdbsum/8dsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dsv ProSAT]</span></td></tr>
	[[Category: Dulchavsky, M]]		</table>
	[[Category: ~~Wu, K~~]]		== Function ==
	[[Category: ~~Bardwell, J.C.A~~]]		[https://www.uniprot.org/uniprot/A0A7H5R8G3_PSEPU A0A7H5R8G3_PSEPU]
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Pseudomonas putida]]
			[[Category: Bardwell JCA]]
			[[Category: Dulchavsky M]]
			[[Category: Li J]]
			[[Category: Wu K]]

OCA at 05:31, 31 August 2022

2022-08-31T05:31:41Z

← Older revision		Revision as of 05:31, 31 August 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8dsv is ON HOLD		The entry 8dsv is ON HOLD until Paper Publication

	Authors: Wu, K., Dulchavsky, M., Li, J., Bardwell, J.C.A.		Authors: Wu, K., Dulchavsky, M., Li, J., Bardwell, J.C.A.
Line 7:		Line 7:
	Description: The structure of NicA2 in complex with N-methylmyosmine		Description: The structure of NicA2 in complex with N-methylmyosmine
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
			[[Category: Li, J]]
			[[Category: Dulchavsky, M]]
	[[Category: Wu, K]]		[[Category: Wu, K]]
	~~[[Category: Li, J]]~~
	[[Category: Bardwell, J.C.A]]		[[Category: Bardwell, J.C.A]]
	~~[[Category: Dulchavsky, M]]~~

OCA: Protected "8dsv" [edit=sysop:move=sysop]

2022-08-03T03:55:41Z

Protected "8dsv" [edit=sysop:move=sysop]

← Older revision	Revision as of 03:55, 3 August 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8dsv is ON HOLD Authors: Wu, K., Dulchavsky, M., Li, J., Bardwell, J.C.A. Description: The structure of NicA2 in complex with N-methylmyosmine [[Ca...

2022-08-03T03:55:40Z

New page: '''Unreleased structure''' The entry 8dsv is ON HOLD Authors: Wu, K., Dulchavsky, M., Li, J., Bardwell, J.C.A. Description: The structure of NicA2 in complex with N-methylmyosmine [[Ca...

New page

'''Unreleased structure'''

The entry 8dsv is ON HOLD

Authors: Wu, K., Dulchavsky, M., Li, J., Bardwell, J.C.A.

Description: The structure of NicA2 in complex with N-methylmyosmine
[[Category: Unreleased Structures]]
[[Category: Wu, K]]
[[Category: Li, J]]
[[Category: Bardwell, J.C.A]]
[[Category: Dulchavsky, M]]