8dwt - Revision history

OCA at 05:23, 12 June 2024

2024-06-12T05:23:18Z

← Older revision		Revision as of 05:23, 12 June 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8dwt]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DWT FirstGlance]. <br>		<table><tr><td colspan='2'>[[8dwt]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DWT FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dwt OCA], [https://pdbe.org/8dwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dwt RCSB], [https://www.ebi.ac.uk/pdbsum/8dwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dwt ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 6.2Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dwt OCA], [https://pdbe.org/8dwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dwt RCSB], [https://www.ebi.ac.uk/pdbsum/8dwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dwt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/SPOP_HUMAN SPOP_HUMAN] Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (By similarity). In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3.<ref>PMID:14528312</ref> <ref>PMID:15897469</ref> <ref>PMID:16524876</ref>		[https://www.uniprot.org/uniprot/SPOP_HUMAN SPOP_HUMAN] Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (By similarity). In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3.<ref>PMID:14528312</ref> <ref>PMID:15897469</ref> <ref>PMID:16524876</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The speckle-type POZ protein (SPOP) functions in the Cullin3-RING ubiquitin ligase (CRL3) as a receptor for the recognition of substrates involved in cell growth, survival, and signaling. SPOP mutations have been attributed to the development of many types of cancers, including prostate and endometrial cancers. Prostate cancer mutations localize in the substrate-binding site of the substrate recognition (MATH) domain and reduce or prevent binding. However, most endometrial cancer mutations are dispersed in seemingly inconspicuous solvent-exposed regions of SPOP, offering no clear basis for their cancer-causing and peculiar gain-of-function properties. Herein, we present the first structure of SPOP in its oligomeric form, uncovering several new interfaces important for SPOP self-assembly and normal function. Given that many previously unaccounted-for cancer mutations are localized in these newly identified interfaces, we uncover molecular mechanisms underlying dysregulation of SPOP function, with effects ranging from gross structural changes to enhanced self-association, and heightened stability and activity.

			Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation.,Cuneo MJ, O'Flynn BG, Lo YH, Sabri N, Mittag T Mol Cell. 2023 Mar 2;83(5):731-745.e4. doi: 10.1016/j.molcel.2022.12.033. Epub , 2023 Jan 23. PMID:36693379<ref>PMID:36693379</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 8dwt" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Speckle-type POZ protein 3D structures\|Speckle-type POZ protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:32, 18 January 2023

2023-01-18T07:32:50Z

← Older revision		Revision as of 07:32, 18 January 2023
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8dwt is ~~ON HOLD until Paper Publication~~		==SPOP W22R Form 2==
			<StructureSection load='8dwt' size='340' side='right'caption='[[8dwt]], [[Resolution\|resolution]] 6.20Å' scene=''>
	~~Authors~~: ~~Cuneo~~, M.J., ~~Mittag~~, T., ~~O''Flynn~~, B., Lo, Y.H.		== Structural highlights ==
			<table><tr><td colspan='2'>[[8dwt]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DWT FirstGlance]. <br>
	~~Description~~: ~~SPOP W22R Form 2~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dwt OCA], [https://pdbe.org/8dwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dwt RCSB], [https://www.ebi.ac.uk/pdbsum/8dwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dwt ProSAT]</span></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		</table>
	[[Category: Cuneo~~, M.J~~]]		== Function ==
	[[Category: Lo~~, Y.H~~]]		[https://www.uniprot.org/uniprot/SPOP_HUMAN SPOP_HUMAN] Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (By similarity). In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3.<ref>PMID:14528312</ref> <ref>PMID:15897469</ref> <ref>PMID:16524876</ref>
	[[Category: Mittag, T]]		== References ==
	[[Category: O''Flynn, B]]		<references/>
			__TOC__
			</StructureSection>
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Cuneo MJ]]
			[[Category: Lo YH]]
			[[Category: Mittag T]]
			[[Category: O'Flynn B]]

OCA at 05:33, 31 August 2022

2022-08-31T05:33:25Z

← Older revision		Revision as of 05:33, 31 August 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8dwt is ON HOLD		The entry 8dwt is ON HOLD until Paper Publication

	Authors: Cuneo, M.J., Mittag, T., O''Flynn, B., Lo, Y.H.		Authors: Cuneo, M.J., Mittag, T., O''Flynn, B., Lo, Y.H.

	Description: SPOP W22R ~~Tetrameric~~ Form		Description: SPOP W22R Form 2
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	~~[[Category: Mittag, T]]~~
	[[Category: Cuneo, M.J]]		[[Category: Cuneo, M.J]]
	[[Category: Lo, Y.H]]		[[Category: Lo, Y.H]]
			[[Category: Mittag, T]]
	[[Category: O''Flynn, B]]		[[Category: O''Flynn, B]]

OCA: Protected "8dwt" [edit=sysop:move=sysop]

2022-08-10T04:05:09Z

Protected "8dwt" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:05, 10 August 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8dwt is ON HOLD Authors: Cuneo, M.J., Mittag, T., O''Flynn, B., Lo, Y.H. Description: SPOP W22R Tetrameric Form Category: Unreleased Structures...

2022-08-10T04:05:08Z

New page: '''Unreleased structure''' The entry 8dwt is ON HOLD Authors: Cuneo, M.J., Mittag, T., O''Flynn, B., Lo, Y.H. Description: SPOP W22R Tetrameric Form Category: Unreleased Structures...

New page

'''Unreleased structure'''

The entry 8dwt is ON HOLD

Authors: Cuneo, M.J., Mittag, T., O''Flynn, B., Lo, Y.H.

Description: SPOP W22R Tetrameric Form
[[Category: Unreleased Structures]]
[[Category: Mittag, T]]
[[Category: Cuneo, M.J]]
[[Category: Lo, Y.H]]
[[Category: O''Flynn, B]]