8e8a - Revision history

OCA at 10:19, 25 October 2023

2023-10-25T10:19:25Z

← Older revision		Revision as of 10:19, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8e8a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[8e8a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E8A FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e8a OCA], [https://pdbe.org/8e8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e8a RCSB], [https://www.ebi.ac.uk/pdbsum/8e8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e8a ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e8a OCA], [https://pdbe.org/8e8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e8a RCSB], [https://www.ebi.ac.uk/pdbsum/8e8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e8a ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 07:01, 8 February 2023

2023-02-08T07:01:25Z

← Older revision		Revision as of 07:01, 8 February 2023
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/POLH_HUMAN POLH_HUMAN] DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci.<ref>PMID:10385124</ref> <ref>PMID:11743006</ref> <ref>PMID:11376341</ref> <ref>PMID:14630940</ref> <ref>PMID:14734526</ref>		[https://www.uniprot.org/uniprot/POLH_HUMAN POLH_HUMAN] DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci.<ref>PMID:10385124</ref> <ref>PMID:11743006</ref> <ref>PMID:11376341</ref> <ref>PMID:14630940</ref> <ref>PMID:14734526</ref>

			==See Also==
			*[[DNA polymerase 3D structures\|DNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:21, 1 February 2023

2023-02-01T11:21:59Z

← Older revision		Revision as of 11:21, 1 February 2023
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8e8a is ~~ON HOLD until Paper Publication~~		==Human DNA polymerase eta-DNA-dT-ended primer binary complex==
			<StructureSection load='8e8a' size='340' side='right'caption='[[8e8a]], [[Resolution\|resolution]] 1.80Å' scene=''>
	~~Authors~~: ~~Chang~~, C., ~~Gao, Y~~.		== Structural highlights ==
			<table><tr><td colspan='2'>[[8e8a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E8A FirstGlance]. <br>
	~~Description~~: ~~Human~~ DNA polymerase ~~eta-~~DNA-dT-~~ended primer binary complex~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e8a OCA], [https://pdbe.org/8e8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e8a RCSB], [https://www.ebi.ac.uk/pdbsum/8e8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e8a ProSAT]</span></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		</table>
	[[Category: ~~Gao, Y~~]]		== Disease ==
	[[Category: Chang, C]]		[https://www.uniprot.org/uniprot/POLH_HUMAN POLH_HUMAN] Defects in POLH are the cause of xeroderma pigmentosum variant type (XPV) [MIM:[https://omim.org/entry/278750 278750]; also designated as XP-V. Xeroderma pigmentosum (XP) is an autosomal recessive disease due to deficient nucleotide excision repair. It is characterized by hypersensitivity of the skin to sunlight, followed by high incidence of skin cancer and frequent neurologic abnormalities. XPV shows normal nucleotide excision repair, but an exaggerated delay in recovery of replicative DNA synthesis. Most XPV patients do not develop clinical symptoms and skin neoplasias until a later age. Clinical manifestations are limited to photo-induced deterioration of the skin and eyes.<ref>PMID:10385124</ref> <ref>PMID:10398605</ref> <ref>PMID:11032022</ref> <ref>PMID:11121129</ref> <ref>PMID:11773631</ref>
			== Function ==
			[https://www.uniprot.org/uniprot/POLH_HUMAN POLH_HUMAN] DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci.<ref>PMID:10385124</ref> <ref>PMID:11743006</ref> <ref>PMID:11376341</ref> <ref>PMID:14630940</ref> <ref>PMID:14734526</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Synthetic construct]]
			[[Category: Chang C]]
			[[Category: Gao Y]]

OCA at 05:46, 14 September 2022

2022-09-14T05:46:24Z

← Older revision		Revision as of 05:46, 14 September 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8e8a is ON HOLD		The entry 8e8a is ON HOLD until Paper Publication

	Authors: Chang, C., Gao, Y.		Authors: Chang, C., Gao, Y.

OCA: Protected "8e8a" [edit=sysop:move=sysop]

2022-08-31T05:39:30Z

Protected "8e8a" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:39, 31 August 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8e8a is ON HOLD Authors: Chang, C., Gao, Y. Description: Human DNA polymerase eta-DNA-dT-ended primer binary complex [[Category: Unreleased Structu...

2022-08-31T05:39:29Z

New page: '''Unreleased structure''' The entry 8e8a is ON HOLD Authors: Chang, C., Gao, Y. Description: Human DNA polymerase eta-DNA-dT-ended primer binary complex [[Category: Unreleased Structu...

New page

'''Unreleased structure'''

The entry 8e8a is ON HOLD

Authors: Chang, C., Gao, Y.

Description: Human DNA polymerase eta-DNA-dT-ended primer binary complex
[[Category: Unreleased Structures]]
[[Category: Gao, Y]]
[[Category: Chang, C]]