8efd - Revision history

OCA at 06:35, 19 June 2024

2024-06-19T06:35:36Z

← Older revision		Revision as of 06:35, 19 June 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8efd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EFD FirstGlance]. <br>		<table><tr><td colspan='2'>[[8efd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EFD FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8efd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8efd OCA], [https://pdbe.org/8efd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8efd RCSB], [https://www.ebi.ac.uk/pdbsum/8efd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8efd ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.8Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8efd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8efd OCA], [https://pdbe.org/8efd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8efd RCSB], [https://www.ebi.ac.uk/pdbsum/8efd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8efd ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 10:		Line 11:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/MYH7_HUMAN MYH7_HUMAN] Muscle contraction.		[https://www.uniprot.org/uniprot/MYH7_HUMAN MYH7_HUMAN] Muscle contraction.

			==See Also==
			*[[Myosin 3D Structures\|Myosin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:42, 11 January 2023

2023-01-11T07:42:44Z

← Older revision		Revision as of 07:42, 11 January 2023
Line 1:		Line 1:
	~~'''Unreleased structure'''~~

	~~The entry~~ 8efd is ~~ON HOLD~~		==Human cardiac myosin II and associated essential light chain in the rigor conformation==
			<StructureSection load='8efd' size='340' side='right'caption='[[8efd]], [[Resolution\|resolution]] 3.80Å' scene=''>
	~~Authors~~: ~~Doran~~, M.H., ~~Lehman~~, W., ~~Rynkiewicz~~, M.J.		== Structural highlights ==
			<table><tr><td colspan='2'>[[8efd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EFD FirstGlance]. <br>
	~~Description~~: ~~Human~~ cardiac myosin II and ~~associated essential light~~ chain in the ~~rigor conformation~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8efd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8efd OCA], [https://pdbe.org/8efd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8efd RCSB], [https://www.ebi.ac.uk/pdbsum/8efd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8efd ProSAT]</span></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		</table>
	[[Category: ~~Lehman, W~~]]		== Disease ==
	[[Category: Doran~~, M.H~~]]		[https://www.uniprot.org/uniprot/MYH7_HUMAN MYH7_HUMAN] Defects in MYH7 are the cause of familial hypertrophic cardiomyopathy type 1 (CMH1) [MIM:[https://omim.org/entry/192600 192600]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.<ref>PMID:1975517</ref> <ref>PMID:1417858</ref> <ref>PMID:1638703</ref> <ref>PMID:1552912</ref> <ref>PMID:8250038</ref> <ref>PMID:8343162</ref> <ref>PMID:8435239</ref> <ref>PMID:8268932</ref> <ref>PMID:8254035</ref> <ref>PMID:8483915</ref> <ref>PMID:7848441</ref> <ref>PMID:7874131</ref> <ref>PMID:8282798</ref> <ref>PMID:7581410</ref> <ref>PMID:7731997</ref> <ref>PMID:8655135</ref> <ref>PMID:8899546</ref> <ref>PMID:10065021</ref> <ref>PMID:9544842</ref> <ref>PMID:9829907</ref> <ref>PMID:9822100</ref> <ref>PMID:10521296</ref> <ref>PMID:10563488</ref> <ref>PMID:10329202</ref> <ref>PMID:10679957</ref> <ref>PMID:10862102</ref> <ref>PMID:11113006</ref> <ref>PMID:11214007</ref> <ref>PMID:11733062</ref> <ref>PMID:11424919</ref> <ref>PMID:11133230</ref> <ref>PMID:12081993</ref> <ref>PMID:11861413</ref> <ref>PMID:11968089</ref> <ref>PMID:12951062</ref> <ref>PMID:12566107</ref> <ref>PMID:12707239</ref> <ref>PMID:12974739</ref> <ref>PMID:12820698</ref> <ref>PMID:12975413</ref> <ref>PMID:12590187</ref> <ref>PMID:12818575</ref> <ref>PMID:15358028</ref> <ref>PMID:15563892</ref> <ref>PMID:15483641</ref> <ref>PMID:15858117</ref> <ref>PMID:16199542</ref> <ref>PMID:15856146</ref> <ref>PMID:16650083</ref> <ref>PMID:16938236</ref> <ref>PMID:17372140</ref> <ref>PMID:18403758</ref> Defects in MYH7 are the cause of myopathy myosin storage (MYOMS) [MIM:[https://omim.org/entry/608358 608358]. In this disorder, muscle biopsy shows type 1 fiber predominance and increased interstitial fat and connective tissue. Inclusion bodies consisting of the beta cardiac myosin heavy chain are present in the majority of type 1 fibers, but not in type 2 fibers.<ref>PMID:14520662</ref> <ref>PMID:15136674</ref> <ref>PMID:17336526</ref> Defects in MYH7 are the cause of scapuloperoneal myopathy MYH7-related (SPMM) [MIM:[https://omim.org/entry/181430 181430]; also known as scapuloperoneal syndrome myopathic type. SPMM is a progressive muscular atrophia beginning in the lower legs and affecting the shoulder region earlier and more severely than distal arm.<ref>PMID:17336526</ref> Defects in MYH7 are a cause of cardiomyopathy dilated type 1S (CMD1S) [MIM:[https://omim.org/entry/613426 613426]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:11106718</ref> <ref>PMID:12379228</ref> <ref>PMID:15769782</ref> <ref>PMID:21846512</ref> Defects in MYH7 are the cause of myopathy distal type 1 (MPD1) [MIM:[https://omim.org/entry/160500 160500]. MPD1 is a muscular disorder characterized by early-onset selective weakness of the great toe and ankle dorsiflexors, followed by weakness of the finger extensors. Mild proximal weakness occasionally develops years later after the onset of the disease.<ref>PMID:15322983</ref> <ref>PMID:17548557</ref>
	[[Category: Rynkiewicz~~, M.J~~]]		== Function ==
			[https://www.uniprot.org/uniprot/MYH7_HUMAN MYH7_HUMAN] Muscle contraction.
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Mus musculus]]
			[[Category: Doran MH]]
			[[Category: Lehman W]]
			[[Category: Rynkiewicz MJ]]

OCA: Protected "8efd" [edit=sysop:move=sysop]

2022-09-14T05:52:07Z

Protected "8efd" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:52, 14 September 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8efd is ON HOLD Authors: Doran, M.H., Lehman, W., Rynkiewicz, M.J. Description: Human cardiac myosin II and associated essential light chain in the...

2022-09-14T05:52:06Z

New page: '''Unreleased structure''' The entry 8efd is ON HOLD Authors: Doran, M.H., Lehman, W., Rynkiewicz, M.J. Description: Human cardiac myosin II and associated essential light chain in the...

New page

'''Unreleased structure'''

The entry 8efd is ON HOLD

Authors: Doran, M.H., Lehman, W., Rynkiewicz, M.J.

Description: Human cardiac myosin II and associated essential light chain in the rigor conformation
[[Category: Unreleased Structures]]
[[Category: Lehman, W]]
[[Category: Doran, M.H]]
[[Category: Rynkiewicz, M.J]]