OCA at 07:59, 6 December 2023

2023-12-06T07:59:37Z

← Older revision		Revision as of 07:59, 6 December 2023
Line 1:		Line 1:
	~~'''Unreleased structure'''~~

	~~The entry~~ 8ff2 is ~~ON HOLD until Paper Publication~~		==Amyloid-beta (1-40) fibrils derived from a CAA patient==
			<StructureSection load='8ff2' size='340' side='right'caption='[[8ff2]], [[Resolution\|resolution]] 2.87Å' scene=''>
	~~Authors~~: ~~Crooks~~, E.J., Fu, Z., ~~Chowdhury~~, S., ~~Smith~~, S.O.		== Structural highlights ==
			<table><tr><td colspan='2'>[[8ff2]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FF2 FirstGlance]. <br>
	~~Description~~: ~~Amyloid~~-beta (1-40) ~~fibrils derived from a CAA patient~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.87Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ff2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ff2 OCA], [https://pdbe.org/8ff2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ff2 RCSB], [https://www.ebi.ac.uk/pdbsum/8ff2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ff2 ProSAT]</span></td></tr>
	[[Category: Chowdhury, S]]		</table>
	[[Category: ~~Fu, Z~~]]		== Disease ==
	[[Category: ~~Smith, S.O~~]]		[https://www.uniprot.org/uniprot/A4_HUMAN A4_HUMAN] Defects in APP are the cause of Alzheimer disease type 1 (AD1) [MIM:[https://omim.org/entry/104300 104300]. AD1 is a familial early-onset form of Alzheimer disease. It can be associated with cerebral amyloid angiopathy. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death.<ref>PMID:8476439</ref> <ref>PMID:15201367</ref> <ref>PMID:1671712</ref> <ref>PMID:1908231</ref> <ref>PMID:1678058</ref> <ref>PMID:1944558</ref> <ref>PMID:1925564</ref> <ref>PMID:1415269</ref> <ref>PMID:1303239</ref> <ref>PMID:1302033</ref> <ref>PMID:1303275</ref> <ref>PMID:8267572</ref> <ref>PMID:8290042</ref> <ref>PMID:8577393</ref> <ref>PMID:9328472</ref> <ref>PMID:9754958</ref> <ref>PMID:10097173</ref> <ref>PMID:10631141</ref> <ref>PMID:10665499</ref> <ref>PMID:10867787</ref> <ref>PMID:11063718</ref> <ref>PMID:11311152</ref> <ref>PMID:11528419</ref> <ref>PMID:12034808</ref> <ref>PMID:15365148</ref> <ref>PMID:15668448</ref> Defects in APP are the cause of cerebral amyloid angiopathy APP-related (CAA-APP) [MIM:[https://omim.org/entry/605714 605714]. A hereditary localized amyloidosis due to amyloid-beta A4 peptide(s) deposition in the cerebral vessels. The principal clinical characteristics are recurrent cerebral and cerebellar hemorrhages, recurrent strokes, cerebral ischemia, cerebral infarction, and progressive mental deterioration. Patients develop cerebral hemorrhage because of the severe cerebral amyloid angiopathy. Parenchymal amyloid deposits are rare and largely in the form of pre-amyloid lesions or diffuse plaque-like structures. They are Congo red negative and lack the dense amyloid cores commonly present in Alzheimer disease. Some affected individuals manifest progressive aphasic dementia, leukoencephalopathy, and occipital calcifications.<ref>PMID:10821838</ref> <ref>PMID:2111584</ref> <ref>PMID:11409420</ref> <ref>PMID:12654973</ref> <ref>PMID:16178030</ref>
	[[Category: ~~Crooks, E.J~~]]		== Function ==
			[https://www.uniprot.org/uniprot/A4_HUMAN A4_HUMAN] Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.<ref>PMID:9168929</ref> <ref>PMID:11544248</ref> <ref>PMID:11943163</ref> <ref>PMID:19225519</ref> <ref>PMID:19901339</ref> Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with Also bind GPC1 in lipid rafts.<ref>PMID:9168929</ref> <ref>PMID:11544248</ref> <ref>PMID:11943163</ref> <ref>PMID:19225519</ref> <ref>PMID:19901339</ref> Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain (By similarity).<ref>PMID:9168929</ref> <ref>PMID:11544248</ref> <ref>PMID:11943163</ref> <ref>PMID:19225519</ref> <ref>PMID:19901339</ref> The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.<ref>PMID:9168929</ref> <ref>PMID:11544248</ref> <ref>PMID:11943163</ref> <ref>PMID:19225519</ref> <ref>PMID:19901339</ref> N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).<ref>PMID:9168929</ref> <ref>PMID:11544248</ref> <ref>PMID:11943163</ref> <ref>PMID:19225519</ref> <ref>PMID:19901339</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Chowdhury S]]
			[[Category: Crooks EJ]]
			[[Category: Fu Z]]
			[[Category: Smith SO]]

OCA at 05:02, 18 January 2023

2023-01-18T05:02:47Z

← Older revision		Revision as of 05:02, 18 January 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8ff2 is ON HOLD		The entry 8ff2 is ON HOLD until Paper Publication

	Authors: Crooks, E.J., Fu, Z., Chowdhury, S., Smith, S.O.		Authors: Crooks, E.J., Fu, Z., Chowdhury, S., Smith, S.O.
Line 7:		Line 7:
	Description: Amyloid-beta (1-40) fibrils derived from a CAA patient		Description: Amyloid-beta (1-40) fibrils derived from a CAA patient
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	~~[[Category: Crooks, E.J]]~~
	[[Category: Chowdhury, S]]		[[Category: Chowdhury, S]]
	[[Category: Fu, Z]]		[[Category: Fu, Z]]
	[[Category: Smith, S.O]]		[[Category: Smith, S.O]]
			[[Category: Crooks, E.J]]

OCA at 05:50, 28 December 2022

2022-12-28T05:50:57Z

← Older revision		Revision as of 05:50, 28 December 2022
Line 3:		Line 3:
	The entry 8ff2 is ON HOLD		The entry 8ff2 is ON HOLD

	Authors: Crooks, E.J., ~~Smith~~, S.O., ~~Chowdhury~~, S.		Authors: Crooks, E.J., Fu, Z., Chowdhury, S., Smith, S.O.

	Description: Amyloid-beta (1-40) fibrils derived from a CAA patient		Description: Amyloid-beta (1-40) fibrils derived from a CAA patient
Line 9:		Line 9:
	[[Category: Crooks, E.J]]		[[Category: Crooks, E.J]]
	[[Category: Chowdhury, S]]		[[Category: Chowdhury, S]]
			[[Category: Fu, Z]]
	[[Category: Smith, S.O]]		[[Category: Smith, S.O]]

OCA: Protected "8ff2" [edit=sysop:move=sysop]

2022-12-14T07:47:52Z

Protected "8ff2" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:47, 14 December 2022
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8ff2 is ON HOLD Authors: Crooks, E.J., Smith, S.O., Chowdhury, S. Description: Amyloid-beta (1-40) fibrils derived from a CAA patient [[Category: U...

2022-12-14T07:47:50Z

New page: '''Unreleased structure''' The entry 8ff2 is ON HOLD Authors: Crooks, E.J., Smith, S.O., Chowdhury, S. Description: Amyloid-beta (1-40) fibrils derived from a CAA patient [[Category: U...

New page

'''Unreleased structure'''

The entry 8ff2 is ON HOLD

Authors: Crooks, E.J., Smith, S.O., Chowdhury, S.

Description: Amyloid-beta (1-40) fibrils derived from a CAA patient
[[Category: Unreleased Structures]]
[[Category: Crooks, E.J]]
[[Category: Chowdhury, S]]
[[Category: Smith, S.O]]

8ff2 - Revision history

OCA at 07:59, 6 December 2023

OCA at 05:02, 18 January 2023

OCA at 05:50, 28 December 2022

OCA: Protected "8ff2" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8ff2 is ON HOLD Authors: Crooks, E.J., Smith, S.O., Chowdhury, S. Description: Amyloid-beta (1-40) fibrils derived from a CAA patient [[Category: U...