8fty - Revision history

OCA at 05:24, 12 June 2024

2024-06-12T05:24:57Z

← Older revision		Revision as of 05:24, 12 June 2024
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fty OCA], [https://pdbe.org/8fty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fty RCSB], [https://www.ebi.ac.uk/pdbsum/8fty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fty ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fty OCA], [https://pdbe.org/8fty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fty RCSB], [https://www.ebi.ac.uk/pdbsum/8fty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fty ProSAT]</span></td></tr>
	</table>		</table>
	== ~~Function~~ ==		<div style="background-color:#fffaf0;">
	~~[https~~://~~www~~.~~uniprot~~.~~org~~/~~uniprot~~/~~A0A7E5VY83_TRINI A0A7E5VY83_TRINI]~~		== Publication Abstract from PubMed ==
			The retinal light response in animals originates from the photoisomerization of an opsin-coupled 11-cis-retinaldehyde chromophore. This visual chromophore is enzymatically produced through the action of carotenoid cleavage dioxygenases. Vertebrates require two carotenoid cleavage dioxygenases, beta-carotene oxygenase 1 and retinal pigment epithelium 65 (RPE65), to form 11-cis-retinaldehyde from carotenoid substrates, whereas invertebrates such as insects use a single enzyme known as Neither Inactivation Nor Afterpotential B (NinaB). RPE65 and NinaB couple trans-cis isomerization with hydrolysis and oxygenation, respectively, but the mechanistic relationship of their isomerase activities remains unknown. Here we report the structure of NinaB, revealing details of its active site architecture and mode of membrane binding. Structure-guided mutagenesis studies identify a residue cluster deep within the NinaB substrate-binding cleft that controls its isomerization activity. Our data demonstrate that isomerization activity is mediated by distinct active site regions in NinaB and RPE65-an evolutionary convergence that deepens our understanding of visual system diversity.

			Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore.,Solano YJ, Everett MP, Dang KS, Abueg J, Kiser PD Nat Chem Biol. 2024 Jun;20(6):779-788. doi: 10.1038/s41589-024-01554-z. Epub 2024 , Feb 14. PMID:38355721<ref>PMID:38355721</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 8fty" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:04, 17 January 2024

2024-01-17T10:04:45Z

← Older revision		Revision as of 10:04, 17 January 2024
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8fty is ~~ON HOLD until Paper Publication~~		==Crystal structure of the carotenoid isomerooxygenase, NinaB==
			<StructureSection load='8fty' size='340' side='right'caption='[[8fty]], [[Resolution\|resolution]] 1.95Å' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>[[8fty]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichoplusia_ni Trichoplusia ni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FTY FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fty OCA], [https://pdbe.org/8fty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fty RCSB], [https://www.ebi.ac.uk/pdbsum/8fty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fty ProSAT]</span></td></tr>
			</table>
			== Function ==
			[https://www.uniprot.org/uniprot/A0A7E5VY83_TRINI A0A7E5VY83_TRINI]
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Trichoplusia ni]]
			[[Category: Kiser PD]]
			[[Category: Solano YJ]]

OCA at 04:43, 27 September 2023

2023-09-27T04:43:52Z

← Older revision		Revision as of 04:43, 27 September 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8fty is ON HOLD		The entry 8fty is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 11:48, 20 September 2023

2023-09-20T11:48:01Z

← Older revision		Revision as of 11:48, 20 September 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8fty is ON HOLD ~~until Paper Publication~~		The entry 8fty is ON HOLD

	Authors:		Authors:

OCA: Protected "8fty" [edit=sysop:move=sysop]

2023-01-25T04:58:48Z

Protected "8fty" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:58, 25 January 2023
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8fty is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2023-01-25T04:58:47Z

New page: '''Unreleased structure''' The entry 8fty is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8fty is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]