8git - Revision history

OCA at 19:49, 29 May 2024

2024-05-29T19:49:32Z

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 == Function ==
 [https://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
 __TOC__
 </StructureSection>

OCA at 05:25, 17 April 2024

2024-04-17T05:25:57Z

← Older revision		Revision as of 05:25, 17 April 2024
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	~~'''Unreleased structure'''~~

	~~The entry 8git is ON HOLD until 2025-03-14~~		==Structure of Ternary Complex of mouse cGAS with dsDNA and Bound ATP: with 10mM Mg2+ and 1mM Mn2+==
			<StructureSection load='8git' size='340' side='right'caption='[[8git]], [[Resolution\|resolution]] 2.72Å' scene=''>
	~~Authors: Wu, S., Sohn, J.~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[8git]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GIT FirstGlance]. <br>
	~~Description:~~ Structure of Ternary Complex of mouse cGAS with dsDNA and Bound ATP: with 10mM Mg2+ and 1mM Mn2+		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.72Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	[[Category: Sohn, J]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8git FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8git OCA], [https://pdbe.org/8git PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8git RCSB], [https://www.ebi.ac.uk/pdbsum/8git PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8git ProSAT]</span></td></tr>
	[[Category: Wu, S]]		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Mus musculus]]
			[[Category: Synthetic construct]]
			[[Category: Sohn J]]
			[[Category: Wu S]]

OCA at 07:48, 19 April 2023

2023-04-19T07:48:54Z

← Older revision		Revision as of 07:48, 19 April 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8git is ON HOLD		The entry 8git is ON HOLD until 2025-03-14

	Authors: Wu, S., Sohn, J.		Authors: Wu, S., Sohn, J.

OCA: Protected "8git" [edit=sysop:move=sysop]

2023-03-22T05:43:20Z

Protected "8git" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:43, 22 March 2023
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8git is ON HOLD Authors: Wu, S., Sohn, J. Description: Structure of Ternary Complex of mouse cGAS with dsDNA and Bound ATP: with 10mM Mg2+ and 1mM ...

2023-03-22T05:43:19Z

New page: '''Unreleased structure''' The entry 8git is ON HOLD Authors: Wu, S., Sohn, J. Description: Structure of Ternary Complex of mouse cGAS with dsDNA and Bound ATP: with 10mM Mg2+ and 1mM ...

New page

'''Unreleased structure'''

The entry 8git is ON HOLD

Authors: Wu, S., Sohn, J.

Description: Structure of Ternary Complex of mouse cGAS with dsDNA and Bound ATP: with 10mM Mg2+ and 1mM Mn2+
[[Category: Unreleased Structures]]
[[Category: Sohn, J]]
[[Category: Wu, S]]