OCA at 08:01, 10 April 2024

2024-04-10T08:01:10Z

← Older revision		Revision as of 08:01, 10 April 2024
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8omp is ~~ON HOLD until Paper Publication~~		==Carbonic Anhydrase 2 in Complex with Steriod_Sulphamoyl AKI33==
			<StructureSection load='8omp' size='340' side='right'caption='[[8omp]], [[Resolution\|resolution]] 1.41Å' scene=''>
	~~Authors~~: ~~Brynda~~, J., ~~Rezacova~~, P.M., ~~Kudova~~, E.		== Structural highlights ==
			<table><tr><td colspan='2'>[[8omp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OMP FirstGlance]. <br>
	~~Description~~: ~~Carbonic Anhydrase 2~~ in ~~Complex~~ with ~~Steriod_Sulphamoyl AKI33~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.41Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VQW:[(3~{R},5~{R},8~{R},9~{S},10~{S},13~{S},14~{S},15~{R})-10,13,15-trimethyl-17-oxidanylidene-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-3-yl]+sulfamate'>VQW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	[[Category: ~~Rezacova, P.M~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8omp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8omp OCA], [https://pdbe.org/8omp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8omp RCSB], [https://www.ebi.ac.uk/pdbsum/8omp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8omp ProSAT]</span></td></tr>
	[[Category: Kudova, E]]		</table>
	[[Category: ~~Brynda, J~~]]		== Disease ==
			[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
			== Function ==
			[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Brynda J]]
			[[Category: Kudova E]]
			[[Category: Rezacova PM]]

OCA at 05:42, 3 May 2023

2023-05-03T05:42:02Z

← Older revision		Revision as of 05:42, 3 May 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8omp is ON HOLD		The entry 8omp is ON HOLD until Paper Publication

	Authors: Brynda, J., Rezacova, P.M., Kudova, E.		Authors: Brynda, J., Rezacova, P.M., Kudova, E.

OCA: Protected "8omp" [edit=sysop:move=sysop]

2023-04-12T18:56:17Z

Protected "8omp" [edit=sysop:move=sysop]

← Older revision	Revision as of 18:56, 12 April 2023
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8omp is ON HOLD Authors: Brynda, J., Rezacova, P.M., Kudova, E. Description: Carbonic Anhydrase 2 in Complex with Steriod_Sulphamoyl AKI33 [[Catego...

2023-04-12T18:56:16Z

New page: '''Unreleased structure''' The entry 8omp is ON HOLD Authors: Brynda, J., Rezacova, P.M., Kudova, E. Description: Carbonic Anhydrase 2 in Complex with Steriod_Sulphamoyl AKI33 [[Catego...

New page

'''Unreleased structure'''

The entry 8omp is ON HOLD

Authors: Brynda, J., Rezacova, P.M., Kudova, E.

Description: Carbonic Anhydrase 2 in Complex with Steriod_Sulphamoyl AKI33
[[Category: Unreleased Structures]]
[[Category: Rezacova, P.M]]
[[Category: Kudova, E]]
[[Category: Brynda, J]]

8omp - Revision history

OCA at 08:01, 10 April 2024

OCA at 05:42, 3 May 2023

OCA: Protected "8omp" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8omp is ON HOLD Authors: Brynda, J., Rezacova, P.M., Kudova, E. Description: Carbonic Anhydrase 2 in Complex with Steriod_Sulphamoyl AKI33 [[Catego...