OCA at 06:21, 5 February 2025

2025-02-05T06:21:03Z

← Older revision		Revision as of 06:21, 5 February 2025
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8py2 is ~~ON HOLD until Paper Publication~~		==Cryo-EM structure of the human BRISC dimer complex bound to compound JMS-175-2==
			<StructureSection load='8py2' size='340' side='right'caption='[[8py2]], [[Resolution\|resolution]] 3.32Å' scene=''>
	~~Authors~~: ~~Chandler~~, F., ~~Zeqiraj~~, E.		== Structural highlights ==
			<table><tr><td colspan='2'>[[8py2]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PY2 FirstGlance]. <br>
	~~Description~~: ~~Cryo~~-~~EM structure~~ of the ~~human~~ BRISC ~~dimer~~ complex ~~bound~~ to ~~compound JMS~~-~~175-2~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.32Å</td></tr>
	[[Category: ~~Unreleased Structures~~]]		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=X8C:1-[2,6-bis(chloranyl)phenyl]carbonyl-4-[[2,6-bis(chloranyl)phenyl]carbonylamino]-~{N}-piperidin-4-yl-pyrazole-3-carboxamide'>X8C</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	[[Category: ~~Zeqiraj, E~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8py2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8py2 OCA], [https://pdbe.org/8py2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8py2 RCSB], [https://www.ebi.ac.uk/pdbsum/8py2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8py2 ProSAT]</span></td></tr>
	[[Category: Chandler, F]]		</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/BRCC3_HUMAN BRCC3_HUMAN] Moyamoya angiopathy-short stature-facial dysmorphism-hypergonadotropic hypogonadism syndrome. A chromosomal aberration involving BRCC3 is a cause of pro-lymphocytic T-cell leukemia (T-PLL). Translocation t(X;14)(q28;q11) with TCRA.<ref>PMID:8247530</ref>
			== Function ==
			[https://www.uniprot.org/uniprot/BRCC3_HUMAN BRCC3_HUMAN] Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:20656690, PubMed:24075985, PubMed:26344097, PubMed:26195665). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985).<ref>PMID:14636569</ref> <ref>PMID:16707425</ref> <ref>PMID:17525341</ref> <ref>PMID:19202061</ref> <ref>PMID:19214193</ref> <ref>PMID:19261746</ref> <ref>PMID:19261748</ref> <ref>PMID:19261749</ref> <ref>PMID:20656690</ref> <ref>PMID:24075985</ref> <ref>PMID:26195665</ref> <ref>PMID:26344097</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Chandler F]]
			[[Category: Zeqiraj E]]

OCA at 04:02, 28 August 2024

2024-08-28T04:02:04Z

← Older revision		Revision as of 04:02, 28 August 2024
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8py2 is ON HOLD		The entry 8py2 is ON HOLD until Paper Publication

	Authors: Chandler, F., Zeqiraj, E.		Authors: Chandler, F., Zeqiraj, E.

OCA at 11:08, 17 July 2024

2024-07-17T11:08:15Z

← Older revision		Revision as of 11:08, 17 July 2024
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8py2 is ON HOLD ~~until Paper Publication~~		The entry 8py2 is ON HOLD

	Authors: Chandler, F., Zeqiraj, E.		Authors: Chandler, F., Zeqiraj, E.

OCA at 12:00, 20 September 2023

2023-09-20T12:00:19Z

← Older revision		Revision as of 12:00, 20 September 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8py2 is ON HOLD		The entry 8py2 is ON HOLD until Paper Publication

	Authors: Chandler, F., Zeqiraj, E.		Authors: Chandler, F., Zeqiraj, E.

OCA: Protected "8py2" [edit=sysop:move=sysop]

2023-08-02T09:13:12Z

Protected "8py2" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:13, 2 August 2023
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8py2 is ON HOLD Authors: Chandler, F., Zeqiraj, E. Description: Cryo-EM structure of the human BRISC dimer complex bound to compound JMS-175-2 [[Ca...

2023-08-02T09:13:11Z

New page: '''Unreleased structure''' The entry 8py2 is ON HOLD Authors: Chandler, F., Zeqiraj, E. Description: Cryo-EM structure of the human BRISC dimer complex bound to compound JMS-175-2 [[Ca...

New page