8ref - Revision history

OCA at 07:38, 21 November 2024

2024-11-21T07:38:39Z

← Older revision		Revision as of 07:38, 21 November 2024
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ref FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ref OCA], [https://pdbe.org/8ref PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ref RCSB], [https://www.ebi.ac.uk/pdbsum/8ref PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ref ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ref FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ref OCA], [https://pdbe.org/8ref PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ref RCSB], [https://www.ebi.ac.uk/pdbsum/8ref PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ref ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/~~C5IYE8_HUMAN C5IYE8_HUMAN~~]		[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			CD8(+) T cells are crucial for viral elimination and recovery from viral infection. Nonetheless, the current understanding of the T cell response to SARS-CoV-2 at the antigen level remains limited. The Spike protein is an external structural protein that is prone to mutations, threatening the efficacy of current vaccines. Therefore, we have characterised the immune response towards the immunogenic Spike-derived peptide (S(976-984), VLNDILSRL), restricted to the HLA-A02:01 molecule, which is mutated in both Alpha (S982A) and Omicron BA.1 (L981F) variants of concern. We determined that the mutation in the Alpha variant (S982A) impacted both the stability and conformation of the peptide, bound to HLA-A02:01, in comparison to the original S(976-984). We identified a longer and overlapping immunogenic peptide (S(975-984), SVLNDILSRL) that could be presented by HLA-A02:01, HLA-A11:01 and HLA-B13:01 allomorphs. We showed that S975-specific CD8(+) T cells were weakly cross-reactive to the mutant peptides despite their similar conformations when presented by HLA-A11:01. Altogether, our results show that the impact of SARS-CoV-2 mutations on peptide presentation is HLA allomorph-specific, and that post vaccination there are T cells able to react and cross-react towards the variant of concern peptides.

			The impact of SARS-CoV-2 spike mutation on peptide presentation is HLA allomorph-specific.,Ahn YM, Maddumage JC, Grant EJ, Chatzileontiadou DSM, Perera WWJG, Baker BM, Szeto C, Gras S Curr Res Struct Biol. 2024 Apr 29;7:100148. doi: 10.1016/j.crstbi.2024.100148. , eCollection 2024. PMID:38742159<ref>PMID:38742159</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 8ref" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 05:22, 15 May 2024

2024-05-15T05:22:38Z

← Older revision		Revision as of 05:22, 15 May 2024
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8ref is ~~ON HOLD until Paper Publication~~		==Crystal structure of HLA B*13:01 in complex with SVLNDILARL, an 10-mer epitope from SARS-CoV-2 Spike (S975-984)==
			<StructureSection load='8ref' size='340' side='right'caption='[[8ref]], [[Resolution\|resolution]] 1.90Å' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>[[8ref]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8REF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8REF FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ref FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ref OCA], [https://pdbe.org/8ref PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ref RCSB], [https://www.ebi.ac.uk/pdbsum/8ref PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ref ProSAT]</span></td></tr>
			</table>
			== Function ==
			[https://www.uniprot.org/uniprot/C5IYE8_HUMAN C5IYE8_HUMAN]
			__TOC__
			</StructureSection>
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Severe acute respiratory syndrome coronavirus 2]]
			[[Category: Ahn YM]]
			[[Category: Gras S]]
			[[Category: Maddumage JC]]
			[[Category: Szeto C]]

OCA at 22:05, 27 December 2023

2023-12-27T22:05:41Z

← Older revision		Revision as of 22:05, 27 December 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8ref is ON HOLD		The entry 8ref is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8ref" [edit=sysop:move=sysop]

2023-12-20T08:50:12Z

Protected "8ref" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:50, 20 December 2023
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8ref is ON HOLD Authors: Description: Category: Unreleased Structures

2023-12-20T08:50:11Z

New page: '''Unreleased structure''' The entry 8ref is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8ref is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]