8uin - Revision history

OCA at 05:27, 12 June 2024

2024-06-12T05:27:17Z

← Older revision		Revision as of 05:27, 12 June 2024
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uin OCA], [https://pdbe.org/8uin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uin RCSB], [https://www.ebi.ac.uk/pdbsum/8uin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uin ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uin OCA], [https://pdbe.org/8uin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uin RCSB], [https://www.ebi.ac.uk/pdbsum/8uin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uin ProSAT]</span></td></tr>
	</table>		</table>
	== ~~Function~~ ==		<div style="background-color:#fffaf0;">
	~~[https~~://~~www~~.~~uniprot~~.~~org~~/~~uniprot~~/~~A0A1Y9G8D0_ANOAL A0A1Y9G8D0_ANOAL]~~		== Publication Abstract from PubMed ==
			Salivary complement inhibitors occur in many of the blood feeding arthropod species responsible for transmission of pathogens. During feeding, these inhibitors prevent the production of proinflammatory anaphylatoxins, which may interfere with feeding, and limit formation of the membrane attack complex which could damage arthropod gut tissues. Salivary inhibitors are, in many cases, novel proteins which may be pharmaceutically useful or display unusual mechanisms that could be exploited pharmaceutically. Albicin is a potent inhibitor of the alternative pathway of complement from the saliva of the malaria transmitting mosquito, Anopheles albimanus. Here we describe the cryo-EM structure of albicin bound to C3bBb, the alternative C3 convertase, a proteolytic complex that is responsible for cleavage of C3 and amplification of the complement response. Albicin is shown to induce dimerization of C3bBb, in a manner similar to the bacterial inhibitor SCIN, to form an inactive complex unable to bind the substrate C3. Size exclusion chromatography and structures determined after 30 minutes of incubation of C3b, factor B (FB), factor D (FD) and albicin indicate that FBb dissociates from the inhibited dimeric complex leaving a C3b-albicin dimeric complex which apparently decays more slowly.

			Mechanism of complement inhibition by a mosquito protein revealed through cryo-EM.,Andersen JF, Lei H, Strayer EC, Pham V, Ribeiro JMC Commun Biol. 2024 May 27;7(1):649. doi: 10.1038/s42003-024-06351-x. PMID:38802531<ref>PMID:38802531</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 8uin" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:37, 9 May 2024

2024-05-09T08:37:44Z

← Older revision		Revision as of 08:37, 9 May 2024
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8uin is ~~ON HOLD~~		==Structure of the C3bBb-albicin complex==
			<StructureSection load='8uin' size='340' side='right'caption='[[8uin]], [[Resolution\|resolution]] 3.86Å' scene=''>
	~~Authors~~: ~~Andersen~~, J.F., ~~Lei~~, H.		== Structural highlights ==
			<table><tr><td colspan='2'>[[8uin]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Anopheles_albimanus Anopheles albimanus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UIN FirstGlance]. <br>
	~~Description~~: ~~Structure of the C3bBb-albicin complex~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.86Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	[[Category: Andersen~~, J.F~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uin OCA], [https://pdbe.org/8uin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uin RCSB], [https://www.ebi.ac.uk/pdbsum/8uin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uin ProSAT]</span></td></tr>
	[[Category: Lei, H]]		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/A0A1Y9G8D0_ANOAL A0A1Y9G8D0_ANOAL]
			__TOC__
			</StructureSection>
			[[Category: Anopheles albimanus]]
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Andersen JF]]
			[[Category: Lei H]]

OCA at 08:10, 1 March 2024

2024-03-01T08:10:07Z

← Older revision		Revision as of 08:10, 1 March 2024
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	The entry 8uin is ON HOLD		The entry 8uin is ON HOLD

	Authors: Andersen, J.F., Lei, H~~., Strayer, E., Ribeiro, J.M~~.		Authors: Andersen, J.F., Lei, H.

	Description: ~~Complex~~ of C3bBb ~~with the inhibitor~~ albicin		Description: Structure of the C3bBb-albicin complex
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Andersen, J.F]]		[[Category: Andersen, J.F]]
	[[Category: Lei, H]]		[[Category: Lei, H]]
	~~[[Category: Strayer, E]]~~
	~~[[Category: Ribeiro, J.M]]~~

OCA: Protected "8uin" [edit=sysop:move=sysop]

2023-10-18T12:31:16Z

Protected "8uin" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:31, 18 October 2023
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8uin is ON HOLD Authors: Andersen, J.F., Lei, H., Strayer, E., Ribeiro, J.M. Description: Complex of C3bBb with the inhibitor albicin [[Category: U...

2023-10-18T12:31:14Z

New page: '''Unreleased structure''' The entry 8uin is ON HOLD Authors: Andersen, J.F., Lei, H., Strayer, E., Ribeiro, J.M. Description: Complex of C3bBb with the inhibitor albicin [[Category: U...

New page

'''Unreleased structure'''

The entry 8uin is ON HOLD

Authors: Andersen, J.F., Lei, H., Strayer, E., Ribeiro, J.M.

Description: Complex of C3bBb with the inhibitor albicin
[[Category: Unreleased Structures]]
[[Category: Andersen, J.F]]
[[Category: Lei, H]]
[[Category: Strayer, E]]
[[Category: Ribeiro, J.M]]