8uzz - Revision history

OCA at 05:09, 25 September 2024

2024-09-25T05:09:45Z

← Older revision		Revision as of 05:09, 25 September 2024
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8uzz ~~is ON HOLD until Paper Publication~~		==Structure of TDP1 catalytic domain complexed with compound IB03==
			<StructureSection load='8uzz' size='340' side='right'caption='[[8uzz]], [[Resolution\|resolution]] 1.93Å' scene=''>
	~~Authors~~: ~~Lountos, G~~.T., ~~Zhao, X.Z~~., ~~Barakat~~, I., ~~Wang~~, W., ~~Agama~~, K., ~~Al Mahmud~~, M.R., ~~Pommier, Y~~., ~~Burke Jr.~~, T.R.		== Structural highlights ==
			<table><tr><td colspan='2'>[[8uzz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UZZ FirstGlance]. <br>
	~~Description~~: ~~Structure~~ of ~~TDP1 catalytic domain complexed~~ with ~~compound IB03~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.93Å</td></tr>
	[[Category: ~~Unreleased Structures~~]]		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=YA5:8-(2-fluorosulfonyloxyphenyl)-4-oxidanylidene-1~{H}-quinoline-3-carboxylic+acid'>YA5</scene></td></tr>
	[[Category: ~~Pommier, Y~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uzz OCA], [https://pdbe.org/8uzz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uzz RCSB], [https://www.ebi.ac.uk/pdbsum/8uzz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uzz ProSAT]</span></td></tr>
	[[Category: ~~Burke Jr~~]]		</table>
	[[Category: ~~Zhao, X.Z~~]]		== Disease ==
	[[Category: Barakat, I]]		[https://www.uniprot.org/uniprot/TYDP1_HUMAN TYDP1_HUMAN] Defects in TDP1 are the cause of spinocerebellar ataxia autosomal recessive with axonal neuropathy (SCAN1) [MIM:[https://omim.org/entry/607250 607250]. SCAN1 is an autosomal recessive cerebellar ataxia (ARCA) associated with peripheral axonal motor and sensory neuropathy, distal muscular atrophy, pes cavus and steppage gait as seen in Charcot-Marie-Tooth neuropathy. All affected individuals have normal intelligence.<ref>PMID:16141202</ref> <ref>PMID:15647511</ref> <ref>PMID:12244316</ref> <ref>PMID:17948061</ref> <ref>PMID:15920477</ref>
	[[Category: ~~Lountos, G.T~~]]		== Function ==
	[[Category: ~~Wang, W~~]]		[https://www.uniprot.org/uniprot/TYDP1_HUMAN TYDP1_HUMAN] DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.<ref>PMID:12023295</ref> <ref>PMID:15111055</ref> <ref>PMID:15811850</ref> <ref>PMID:16141202</ref> <ref>PMID:22822062</ref>
	[[Category: ~~T.R~~]]		== References ==
	[[Category: ~~Al Mahmud, M.R~~]]		<references/>
	[[Category: ~~Agama, K~~]]		__TOC__
			</StructureSection>
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Agama K]]
			[[Category: Al Mahmud MR]]
			[[Category: Barakat I]]
			[[Category: Burke Jr TR]]
			[[Category: Lountos GT]]
			[[Category: Pommier Y]]
			[[Category: Wang W]]
			[[Category: Zhao XZ]]

OCA at 11:37, 29 May 2024

2024-05-29T11:37:32Z

← Older revision		Revision as of 11:37, 29 May 2024
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	Description: Structure of TDP1 catalytic domain complexed with compound IB03		Description: Structure of TDP1 catalytic domain complexed with compound IB03
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	~~[[Category: Agama, K]]~~
	~~[[Category: Wang, W]]~~
	~~[[Category: Al Mahmud, M.R]]~~
	~~[[Category: Lountos, G.T]]~~
	~~[[Category: T.R]]~~
	[[Category: Pommier, Y]]		[[Category: Pommier, Y]]
			[[Category: Burke Jr]]
	[[Category: Zhao, X.Z]]		[[Category: Zhao, X.Z]]
	[[Category: Barakat, I]]		[[Category: Barakat, I]]
	[[Category: ~~Burke Jr~~]]		[[Category: Lountos, G.T]]
			[[Category: Wang, W]]
			[[Category: T.R]]
			[[Category: Al Mahmud, M.R]]
			[[Category: Agama, K]]

OCA at 10:07, 3 January 2024

2024-01-03T10:07:48Z

← Older revision		Revision as of 10:07, 3 January 2024
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8uzz is ON HOLD		The entry 8uzz is ON HOLD until Paper Publication

	Authors: Lountos, G.T., Zhao, X.Z., Barakat, I., Wang, W., Agama, K., Al Mahmud, M.R., Pommier, Y., Burke Jr., T.R.		Authors: Lountos, G.T., Zhao, X.Z., Barakat, I., Wang, W., Agama, K., Al Mahmud, M.R., Pommier, Y., Burke Jr., T.R.

OCA: Protected "8uzz" [edit=sysop:move=sysop]

2023-11-29T08:32:47Z

Protected "8uzz" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:32, 29 November 2023
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8uzz is ON HOLD Authors: Lountos, G.T., Zhao, X.Z., Barakat, I., Wang, W., Agama, K., Al Mahmud, M.R., Pommier, Y., Burke Jr., T.R. Description: St...

2023-11-29T08:32:45Z

New page: '''Unreleased structure''' The entry 8uzz is ON HOLD Authors: Lountos, G.T., Zhao, X.Z., Barakat, I., Wang, W., Agama, K., Al Mahmud, M.R., Pommier, Y., Burke Jr., T.R. Description: St...

New page

'''Unreleased structure'''

The entry 8uzz is ON HOLD

Authors: Lountos, G.T., Zhao, X.Z., Barakat, I., Wang, W., Agama, K., Al Mahmud, M.R., Pommier, Y., Burke Jr., T.R.

Description: Structure of TDP1 catalytic domain complexed with compound IB03
[[Category: Unreleased Structures]]
[[Category: Agama, K]]
[[Category: Wang, W]]
[[Category: Al Mahmud, M.R]]
[[Category: Lountos, G.T]]
[[Category: T.R]]
[[Category: Pommier, Y]]
[[Category: Zhao, X.Z]]
[[Category: Barakat, I]]
[[Category: Burke Jr]]