8vae - Revision history

OCA at 10:00, 17 October 2024

2024-10-17T10:00:59Z

← Older revision		Revision as of 10:00, 17 October 2024
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	~~'''Unreleased structure'''~~

	~~The entry~~ 8vae is ~~ON HOLD until Paper~~ Publication		==Cryogenic electron microscopy structure of human serum albumin in complex with salicylic acid==
			<StructureSection load='8vae' size='340' side='right'caption='[[8vae]], [[Resolution\|resolution]] 3.70Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[8vae]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VAE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VAE FirstGlance]. <br>
			</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.7Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAL:2-HYDROXYBENZOIC+ACID'>SAL</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vae OCA], [https://pdbe.org/8vae PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vae RCSB], [https://www.ebi.ac.uk/pdbsum/8vae PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vae ProSAT]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Human serum albumin (HSA) is the most prevalent plasma protein in the human body, accounting for 60 % of the total plasma protein. HSA plays a major pharmacokinetic function, serving as a facilitator in the distribution of endobiotics and xenobiotics within the organism. In this paper we report the cryoEM structures of HSA in the apo form and in complex with two ligands (salicylic acid and teniposide) at a resolution of 3.5, 3.7 and 3.4 A, respectively. We expand upon previously published work and further demonstrate that sub-4 A maps of approximately 60 kDa proteins can be routinely obtained using a 200 kV microscope, employing standard workflows. Most importantly, these maps allowed for the identification of small molecule ligands, emphasizing the practical applicability of this methodology and providing a starting point for subsequent computational modeling and in silico optimization.

	~~Authors:~~ Catalano, C., Lucier~~, K.W.~~, To, D., Senko, S., Tran~~, N.L.~~, Farwell~~, A.C.~~, Silva~~, S.M.~~, Dip~~, P.V.~~, Poweleit, N., Scapin, G.		The CryoEM structure of human serum albumin in complex with ligands.,Catalano C, Lucier KW, To D, Senko S, Tran NL, Farwell AC, Silva SM, Dip PV, Poweleit N, Scapin G J Struct Biol. 2024 Sep;216(3):108105. doi: 10.1016/j.jsb.2024.108105. Epub 2024 , Jun 8. PMID:38852682<ref>PMID:38852682</ref>

	~~Description~~: ~~Cryogenic electron microscopy structure of human serum albumin in complex with salicylic acid~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	[[Category: ~~Unreleased~~ Structures]]		</div>
	[[Category: ~~Dip, P.V~~]]		<div class="pdbe-citations 8vae" style="background-color:#fffaf0;"></div>
	[[Category: ~~Tran, N.L~~]]		== References ==
	[[Category: ~~To, D~~]]		<references/>
	[[Category: ~~Silva, S.M~~]]		__TOC__
	[[Category: ~~Scapin, G~~]]		</StructureSection>
	[[Category: ~~Lucier, K.W~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Poweleit, N~~]]		[[Category: Large Structures]]
	[[Category: ~~Farwell, A.C~~]]		[[Category: Catalano C]]
	[[Category: ~~Senko, S~~]]		[[Category: Dip PV]]
	[[Category: ~~Catalano, C~~]]		[[Category: Farwell AC]]
			[[Category: Lucier KW]]
			[[Category: Poweleit N]]
			[[Category: Scapin G]]
			[[Category: Senko S]]
			[[Category: Silva SM]]
			[[Category: To D]]
			[[Category: Tran NL]]

OCA at 11:45, 29 May 2024

2024-05-29T11:45:22Z

← Older revision		Revision as of 11:45, 29 May 2024
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Dip, P.V]]		[[Category: Dip, P.V]]
	[[Category: ~~Catalano~~, ~~C]]~~		[[Category: Tran, N.L]]
	~~[[Category: Farwell, A.C]]~~		[[Category: To, D]]
	~~[[Category: Lucier, K~~.W]]
	[[Category: ~~Senko~~, S]]
	[[Category: Silva, S.M]]		[[Category: Silva, S.M]]
	[[Category: Scapin, G]]		[[Category: Scapin, G]]
			[[Category: Lucier, K.W]]
	[[Category: Poweleit, N]]		[[Category: Poweleit, N]]
	[[Category: ~~Tran~~, N.L]]		[[Category: Farwell, A.C]]
	[[Category: To, D]]		[[Category: Senko, S]]
			[[Category: Catalano, C]]

OCA at 08:59, 17 January 2024

2024-01-17T08:59:16Z

← Older revision		Revision as of 08:59, 17 January 2024
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 8vae is ON HOLD		The entry 8vae is ON HOLD until Paper Publication

	Authors: Catalano, C., Lucier, K.W., To, D., Senko, S., Tran, N.L., Farwell, A.C., Silva, S.M., Dip, P.V., Poweleit, N., Scapin, G.		Authors: Catalano, C., Lucier, K.W., To, D., Senko, S., Tran, N.L., Farwell, A.C., Silva, S.M., Dip, P.V., Poweleit, N., Scapin, G.
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	[[Category: Dip, P.V]]		[[Category: Dip, P.V]]
	[[Category: Catalano, C]]		[[Category: Catalano, C]]
			[[Category: Farwell, A.C]]
	[[Category: Lucier, K.W]]		[[Category: Lucier, K.W]]
			[[Category: Senko, S]]
	[[Category: Silva, S.M]]		[[Category: Silva, S.M]]
	[[Category: Scapin, G]]		[[Category: Scapin, G]]
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	[[Category: Tran, N.L]]		[[Category: Tran, N.L]]
	[[Category: To, D]]		[[Category: To, D]]
	~~[[Category: Farwell, A.C]]~~
	~~[[Category: Senko, S]]~~

OCA: Protected "8vae" [edit=sysop:move=sysop]

2023-12-20T08:59:23Z

Protected "8vae" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:59, 20 December 2023
(No difference)

OCA: New page: '''Unreleased structure''' The entry 8vae is ON HOLD Authors: Catalano, C., Lucier, K.W., To, D., Senko, S., Tran, N.L., Farwell, A.C., Silva, S.M., Dip, P.V., Poweleit, N., Scapin, G. ...

2023-12-20T08:59:22Z

New page: '''Unreleased structure''' The entry 8vae is ON HOLD Authors: Catalano, C., Lucier, K.W., To, D., Senko, S., Tran, N.L., Farwell, A.C., Silva, S.M., Dip, P.V., Poweleit, N., Scapin, G. ...

New page

'''Unreleased structure'''

The entry 8vae is ON HOLD

Authors: Catalano, C., Lucier, K.W., To, D., Senko, S., Tran, N.L., Farwell, A.C., Silva, S.M., Dip, P.V., Poweleit, N., Scapin, G.

Description: Cryogenic electron microscopy structure of human serum albumin in complex with salicylic acid
[[Category: Unreleased Structures]]
[[Category: Dip, P.V]]
[[Category: Catalano, C]]
[[Category: Lucier, K.W]]
[[Category: Silva, S.M]]
[[Category: Scapin, G]]
[[Category: Poweleit, N]]
[[Category: Tran, N.L]]
[[Category: To, D]]
[[Category: Farwell, A.C]]
[[Category: Senko, S]]