OCA at 07:08, 29 October 2025

2025-10-29T07:08:08Z

← Older revision		Revision as of 07:08, 29 October 2025
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	~~'''Unreleased structure'''~~

	~~The entry~~ 9d2e is ~~ON HOLD until Paper Publication~~		==FoxP3 multimers bridge two T4G repeat DNAs (model1)==
			<StructureSection load='9d2e' size='340' side='right'caption='[[9d2e]], [[Resolution\|resolution]] 2.90Å' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>[[9d2e]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9D2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9D2E FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.9Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9d2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9d2e OCA], [https://pdbe.org/9d2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9d2e RCSB], [https://www.ebi.ac.uk/pdbsum/9d2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9d2e ProSAT]</span></td></tr>
			</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/FOXP3_MOUSE FOXP3_MOUSE] Defects in Foxp3 are the cause of the scurfy phenotype (sf). It results in a lethal disorder of immunoregulation, characterized by infections, diarrhea, anemia, thrombocytopenia, hypogonadism, gastrointestinal bleeding, lymphadenopathy and leukocytosis.
			== Function ==
			[https://www.uniprot.org/uniprot/FOXP3_MOUSE FOXP3_MOUSE] Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (By similarity). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (By similarity). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (PubMed:19696312).[UniProtKB:Q9BZS1]<ref>PMID:15790681</ref> <ref>PMID:17377532</ref> <ref>PMID:18368049</ref> <ref>PMID:19696312</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Mus musculus]]
			[[Category: Synthetic construct]]
			[[Category: Hur S]]
			[[Category: Leng F]]

OCA at 02:48, 5 October 2024

2024-10-05T02:48:10Z

← Older revision		Revision as of 02:48, 5 October 2024
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 9d2e is ON HOLD		The entry 9d2e is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "9d2e" [edit=sysop:move=sysop]

2024-08-14T07:12:01Z

Protected "9d2e" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:12, 14 August 2024
(No difference)

OCA: New page: '''Unreleased structure''' The entry 9d2e is ON HOLD Authors: Description: Category: Unreleased Structures

2024-08-14T07:11:59Z

New page: '''Unreleased structure''' The entry 9d2e is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 9d2e is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

9d2e - Revision history

OCA at 07:08, 29 October 2025

OCA at 02:48, 5 October 2024

OCA: Protected "9d2e" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 9d2e is ON HOLD Authors: Description: Category: Unreleased Structures