9dat - Revision history

OCA at 15:38, 18 February 2026

2026-02-18T15:38:46Z

← Older revision		Revision as of 15:38, 18 February 2026
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	<table><tr><td colspan='2'>[[9dat]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DAT FirstGlance]. <br>		<table><tr><td colspan='2'>[[9dat]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DAT FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.9Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.9Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1SY:CGAMP'>1SY</scene>, <scene name='pdbligand=A1BBH:[(~~2~{R}~~)-2-[(~~~{Z}~~)-~~octadec-9-enoyl]oxy-3-[oxidanyl-~~[(~~2~{R}~~,~~3~{S}~~,~~5~{R}~~,~~6~{R}~~)-2,4,6-~~tris(oxidanyl)~~-3,5-~~diphosphonooxy-~~cyclohexyl]oxy-phosphoryl]oxy-~~propyl]~~+(~~~{Z}~~)-octadec-9-enoate'>A1BBH</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene>, <scene name='pdbligand=Y6H:4-[[4-(2-~{tert}-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methylamino]-3-methoxy-benzoic+acid'>Y6H</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1SY:CGAMP'>1SY</scene>, <scene name='pdbligand=A1BBH:(2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl+di[(9Z)-octadec-9-enoate]'>A1BBH</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene>, <scene name='pdbligand=Y6H:4-[[4-(2-~{tert}-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methylamino]-3-methoxy-benzoic+acid'>Y6H</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dat OCA], [https://pdbe.org/9dat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dat RCSB], [https://www.ebi.ac.uk/pdbsum/9dat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dat ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dat OCA], [https://pdbe.org/9dat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dat RCSB], [https://www.ebi.ac.uk/pdbsum/9dat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dat ProSAT]</span></td></tr>
	</table>		</table>

OCA at 19:42, 10 February 2026

2026-02-10T19:42:36Z

← Older revision		Revision as of 19:42, 10 February 2026
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	<table><tr><td colspan='2'>[[9dat]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DAT FirstGlance]. <br>		<table><tr><td colspan='2'>[[9dat]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DAT FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.9Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.9Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1SY:CGAMP'>1SY</scene>, <scene name='pdbligand=A1BBH:(2R)-3-{[(R)-~~hydroxy{~~[(1S,2R,3R,~~4S,5S,6R~~)-2,4,6-~~trihydroxy~~-3,5-~~bis(phosphonooxy)~~cyclohexyl]oxy}phosphoryl]oxy~~}propane~~-~~1,2-diyl~~+~~di[~~(9Z)-octadec-9-enoate]'>A1BBH</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene>, <scene name='pdbligand=Y6H:4-[[4-(2-~{tert}-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methylamino]-3-methoxy-benzoic+acid'>Y6H</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1SY:CGAMP'>1SY</scene>, <scene name='pdbligand=A1BBH:[(2~{R})-2-[(~{Z})-octadec-9-enoyl]oxy-3-[oxidanyl-[(2~{R},3~{S},5~{R},6~{R})-2,4,6-tris(oxidanyl)-3,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl]+(~{Z})-octadec-9-enoate'>A1BBH</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene>, <scene name='pdbligand=Y6H:4-[[4-(2-~{tert}-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methylamino]-3-methoxy-benzoic+acid'>Y6H</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dat OCA], [https://pdbe.org/9dat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dat RCSB], [https://www.ebi.ac.uk/pdbsum/9dat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dat ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dat OCA], [https://pdbe.org/9dat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dat RCSB], [https://www.ebi.ac.uk/pdbsum/9dat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dat ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:52, 17 December 2025

2025-12-17T12:52:51Z

← Older revision		Revision as of 12:52, 17 December 2025
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	~~'''Unreleased structure'''~~

	~~The entry~~ 9dat is ~~ON HOLD until Paper Publication~~		==STING oligomer bound to PI(3,5)P2==
			<StructureSection load='9dat' size='340' side='right'caption='[[9dat]], [[Resolution\|resolution]] 2.90Å' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>[[9dat]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DAT FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.9Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1SY:CGAMP'>1SY</scene>, <scene name='pdbligand=A1BBH:(2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl+di[(9Z)-octadec-9-enoate]'>A1BBH</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene>, <scene name='pdbligand=Y6H:4-[[4-(2-~{tert}-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methylamino]-3-methoxy-benzoic+acid'>Y6H</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dat OCA], [https://pdbe.org/9dat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dat RCSB], [https://www.ebi.ac.uk/pdbsum/9dat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dat ProSAT]</span></td></tr>
			</table>
			== Function ==
			[https://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Bai X]]
			[[Category: Li J]]
			[[Category: Zhang X]]

OCA at 05:53, 9 October 2024

2024-10-09T05:53:29Z

← Older revision		Revision as of 05:53, 9 October 2024
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 9dat is ON HOLD		The entry 9dat is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "9dat" [edit=sysop:move=sysop]

2024-08-28T04:18:13Z

Protected "9dat" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:18, 28 August 2024
(No difference)

OCA: New page: '''Unreleased structure''' The entry 9dat is ON HOLD Authors: Description: Category: Unreleased Structures

2024-08-28T04:18:12Z

New page: '''Unreleased structure''' The entry 9dat is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 9dat is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]