OCA at 08:18, 13 August 2025

2025-08-13T08:18:55Z

← Older revision		Revision as of 08:18, 13 August 2025
Line 1:		Line 1:
	~~'''Unreleased structure'''~~

	~~The entry~~ 9j4e is ~~ON HOLD until 2026~~-~~08-09~~		==Cryo-EM structure of P25alpha full-length fibril==
			<StructureSection load='9j4e' size='340' side='right'caption='[[9j4e]], [[Resolution\|resolution]] 3.32Å' scene=''>
	~~Authors~~: ~~Xia~~, W.C., ~~Sun~~, Y.P., ~~Huang~~, C.A., ~~Liu~~, C.		== Structural highlights ==
			<table><tr><td colspan='2'>[[9j4e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9J4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9J4E FirstGlance]. <br>
	~~Description~~: ~~Cryo~~-~~EM structure~~ of ~~P25alpha full~~-~~length fibril~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.32Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9j4e OCA], [https://pdbe.org/9j4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9j4e RCSB], [https://www.ebi.ac.uk/pdbsum/9j4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9j4e ProSAT]</span></td></tr>
	[[Category: Huang~~, C.A~~]]		</table>
	[[Category: Liu, C]]		== Function ==
	[[Category: ~~Xia, W.C~~]]		[https://www.uniprot.org/uniprot/TPPP_HUMAN TPPP_HUMAN] Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed:31522887, PubMed:33831707). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed:31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (PubMed:21316364, PubMed:21995432). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:17105200, PubMed:17693641, PubMed:18028908, PubMed:26289831). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (PubMed:20308065, PubMed:23093407). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (PubMed:23093407). Plays a role in cell proliferation by regulating the G1/S-phase transition (PubMed:23355470). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (PubMed:22328514).<ref>PMID:17105200</ref> <ref>PMID:17693641</ref> <ref>PMID:18028908</ref> <ref>PMID:20308065</ref> <ref>PMID:21316364</ref> <ref>PMID:21995432</ref> <ref>PMID:22328514</ref> <ref>PMID:23093407</ref> <ref>PMID:23355470</ref> <ref>PMID:26289831</ref> <ref>PMID:31522887</ref>
	[[Category: ~~Sun, Y.P~~]]		== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Huang CA]]
			[[Category: Liu C]]
			[[Category: Sun YP]]
			[[Category: Xia WC]]

OCA at 04:08, 25 September 2024

2024-09-25T04:08:00Z

← Older revision		Revision as of 04:08, 25 September 2024
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 9j4e is ON HOLD		The entry 9j4e is ON HOLD until 2026-08-09

	Authors: Xia, W.C., Sun, Y.P., Huang, C.A., Liu, C.		Authors: Xia, W.C., Sun, Y.P., Huang, C.A., Liu, C.
Line 7:		Line 7:
	Description: Cryo-EM structure of P25alpha full-length fibril		Description: Cryo-EM structure of P25alpha full-length fibril
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
			[[Category: Huang, C.A]]
	[[Category: Liu, C]]		[[Category: Liu, C]]
	~~[[Category: Huang, C.A]]~~
	[[Category: Xia, W.C]]		[[Category: Xia, W.C]]
	[[Category: Sun, Y.P]]		[[Category: Sun, Y.P]]

OCA: Protected "9j4e" [edit=sysop:move=sysop]

2024-08-14T07:31:32Z

Protected "9j4e" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:31, 14 August 2024
(No difference)

OCA: New page: '''Unreleased structure''' The entry 9j4e is ON HOLD Authors: Xia, W.C., Sun, Y.P., Huang, C.A., Liu, C. Description: Cryo-EM structure of P25alpha full-length fibril [[Category: Unrel...

2024-08-14T07:31:31Z

New page: '''Unreleased structure''' The entry 9j4e is ON HOLD Authors: Xia, W.C., Sun, Y.P., Huang, C.A., Liu, C. Description: Cryo-EM structure of P25alpha full-length fibril [[Category: Unrel...

New page

'''Unreleased structure'''

The entry 9j4e is ON HOLD

Authors: Xia, W.C., Sun, Y.P., Huang, C.A., Liu, C.

Description: Cryo-EM structure of P25alpha full-length fibril
[[Category: Unreleased Structures]]
[[Category: Liu, C]]
[[Category: Huang, C.A]]
[[Category: Xia, W.C]]
[[Category: Sun, Y.P]]

9j4e - Revision history

OCA at 08:18, 13 August 2025

OCA at 04:08, 25 September 2024

OCA: Protected "9j4e" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 9j4e is ON HOLD Authors: Xia, W.C., Sun, Y.P., Huang, C.A., Liu, C. Description: Cryo-EM structure of P25alpha full-length fibril [[Category: Unrel...