OCA at 07:13, 11 February 2026

2026-02-11T07:13:09Z

← Older revision		Revision as of 07:13, 11 February 2026
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	~~'''Unreleased structure'''~~

	~~The entry~~ 9ltf is ~~ON HOLD until Paper Publication~~		==Crystal structure of mSTING-TTB==
			<StructureSection load='9ltf' size='340' side='right'caption='[[9ltf]], [[Resolution\|resolution]] 1.92Å' scene=''>
	~~Authors~~: ~~Zhang~~, C.G., ~~Hou, Y~~.F., ~~Liu~~, P.Y., ~~Fan~~, S.L.		== Structural highlights ==
			<table><tr><td colspan='2'>[[9ltf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LTF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LTF FirstGlance]. <br>
	~~Description~~: ~~Crystal structure~~ of ~~mSTING~~-~~TTB~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.92Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1ELY:~{N}-phenyl-7-(pyridin-4-ylmethoxy)furo[2,3-d]pyridazin-4-amine'>A1ELY</scene></td></tr>
	[[Category: Fan~~, S.L~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ltf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ltf OCA], [https://pdbe.org/9ltf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ltf RCSB], [https://www.ebi.ac.uk/pdbsum/9ltf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ltf ProSAT]</span></td></tr>
	[[Category: Hou~~, Y.F~~]]		</table>
	[[Category: Liu~~, P.Y~~]]		== Function ==
	[[Category: Zhang~~, C.G~~]]		[https://www.uniprot.org/uniprot/STING_MOUSE STING_MOUSE] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18559423</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:23258412</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Mus musculus]]
			[[Category: Fan SL]]
			[[Category: Hou YF]]
			[[Category: Liu PY]]
			[[Category: Zhang CG]]

OCA at 05:16, 19 March 2025

2025-03-19T05:16:12Z

← Older revision		Revision as of 05:16, 19 March 2025
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 9ltf is ON HOLD		The entry 9ltf is ON HOLD until Paper Publication

	Authors: Zhang, C.G., Hou, Y.F., Liu, P.Y., Fan, S.L.		Authors: Zhang, C.G., Hou, Y.F., Liu, P.Y., Fan, S.L.
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	[[Category: Fan, S.L]]		[[Category: Fan, S.L]]
	[[Category: Hou, Y.F]]		[[Category: Hou, Y.F]]
			[[Category: Liu, P.Y]]
	[[Category: Zhang, C.G]]		[[Category: Zhang, C.G]]
	~~[[Category: Liu, P.Y]]~~

OCA: Protected "9ltf" [edit=sysop:move=sysop]

2025-02-12T05:17:55Z

Protected "9ltf" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:17, 12 February 2025
(No difference)

OCA: New page: '''Unreleased structure''' The entry 9ltf is ON HOLD Authors: Zhang, C.G., Hou, Y.F., Liu, P.Y., Fan, S.L. Description: Crystal structure of mSTING-TTB [[Category: Unreleased Structure...

2025-02-12T05:17:54Z

New page: '''Unreleased structure''' The entry 9ltf is ON HOLD Authors: Zhang, C.G., Hou, Y.F., Liu, P.Y., Fan, S.L. Description: Crystal structure of mSTING-TTB [[Category: Unreleased Structure...

New page

'''Unreleased structure'''

The entry 9ltf is ON HOLD

Authors: Zhang, C.G., Hou, Y.F., Liu, P.Y., Fan, S.L.

Description: Crystal structure of mSTING-TTB
[[Category: Unreleased Structures]]
[[Category: Fan, S.L]]
[[Category: Hou, Y.F]]
[[Category: Zhang, C.G]]
[[Category: Liu, P.Y]]

9ltf - Revision history

OCA at 07:13, 11 February 2026

OCA at 05:16, 19 March 2025

OCA: Protected "9ltf" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 9ltf is ON HOLD Authors: Zhang, C.G., Hou, Y.F., Liu, P.Y., Fan, S.L. Description: Crystal structure of mSTING-TTB [[Category: Unreleased Structure...