9py2 - Revision history

OCA at 07:44, 31 December 2025

2025-12-31T07:44:44Z

← Older revision		Revision as of 07:44, 31 December 2025
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	<table><tr><td colspan='2'>[[9py2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9PY2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[9py2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9PY2 FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.16Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.16Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CMV:4-[4-(4-chlorophenyl)-4-~~hydroxypiperidin~~-1-yl]-N,N-dimethyl-2,2-~~diphenylbutanamide~~'>A1CMV</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=VSN:~~[(2~{R},3~{S},4~{R},~~5~~~{R})~~-5-(~~2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl~~)-~~3,4-bis~~(~~oxidanyl~~)~~oxolan-2-yl~~]~~methyl+bis(oxidanyl)phosphinothioyl+hydrogen+phosphate~~'>VSN</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CMV:4-[4-(4-chlorophenyl)-4-oxidanyl-piperidin-1-yl]-~{N},~{N}-dimethyl-2,2-diphenyl-butanamide'>A1CMV</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=VSN:5-O-[(R)-hydroxy(thiophosphonooxy)phosphoryl]guanosine'>VSN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9py2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9py2 OCA], [https://pdbe.org/9py2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9py2 RCSB], [https://www.ebi.ac.uk/pdbsum/9py2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9py2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9py2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9py2 OCA], [https://pdbe.org/9py2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9py2 RCSB], [https://www.ebi.ac.uk/pdbsum/9py2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9py2 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:11, 19 November 2025

2025-11-19T08:11:31Z

← Older revision		Revision as of 08:11, 19 November 2025
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	<table><tr><td colspan='2'>[[9py2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9PY2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[9py2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9PY2 FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.16Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.16Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CMV:4-[4-(4-chlorophenyl)-4-~~oxidanyl-piperidin~~-1-yl]-~{N},~{N}-dimethyl-2,2-~~diphenyl-butanamide~~'>A1CMV</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=VSN:5-O-[(R)-~~hydroxy~~(~~thiophosphonooxy~~)~~phosphoryl~~]~~guanosine~~'>VSN</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CMV:4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide'>A1CMV</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=VSN:[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl+bis(oxidanyl)phosphinothioyl+hydrogen+phosphate'>VSN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9py2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9py2 OCA], [https://pdbe.org/9py2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9py2 RCSB], [https://www.ebi.ac.uk/pdbsum/9py2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9py2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9py2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9py2 OCA], [https://pdbe.org/9py2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9py2 RCSB], [https://www.ebi.ac.uk/pdbsum/9py2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9py2 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:42, 12 November 2025

2025-11-12T07:42:01Z

← Older revision		Revision as of 07:42, 12 November 2025
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	~~'''Unreleased structure'''~~

	~~The entry~~ 9py2 is ~~ON HOLD until Paper Publication~~		==Engaged-state loperamide-mu opioid receptor-Gi GDPbS complex (rebound)==
			<StructureSection load='9py2' size='340' side='right'caption='[[9py2]], [[Resolution\|resolution]] 3.16Å' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>[[9py2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9PY2 FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.16Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CMV:4-[4-(4-chlorophenyl)-4-oxidanyl-piperidin-1-yl]-~{N},~{N}-dimethyl-2,2-diphenyl-butanamide'>A1CMV</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=VSN:5-O-[(R)-hydroxy(thiophosphonooxy)phosphoryl]guanosine'>VSN</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9py2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9py2 OCA], [https://pdbe.org/9py2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9py2 RCSB], [https://www.ebi.ac.uk/pdbsum/9py2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9py2 ProSAT]</span></td></tr>
			</table>
			== Function ==
			[https://www.uniprot.org/uniprot/OPRM_HUMAN OPRM_HUMAN] Receptor for endogenous opioids such as beta-endorphin and endomorphin (PubMed:10529478, PubMed:12589820, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:10529478, PubMed:10836142, PubMed:12589820, PubMed:19300905, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe (By similarity). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors (PubMed:7905839). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:12068084). They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B (By similarity). Also couples to adenylate cyclase stimulatory G alpha proteins (By similarity). The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4 (By similarity). Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization (By similarity). Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction (By similarity). The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins (By similarity). The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation (By similarity). Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling (By similarity). Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling (By similarity). Endogenous ligands induce rapid desensitization, endocytosis and recycling (By similarity). Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties (By similarity).[UniProtKB:P33535]<ref>PMID:10529478</ref> <ref>PMID:12068084</ref> <ref>PMID:12589820</ref> <ref>PMID:7891175</ref> <ref>PMID:7905839</ref> <ref>PMID:7957926</ref> <ref>PMID:9689128</ref> <ref>PMID:10836142</ref> <ref>PMID:19300905</ref> Couples to GNAS and is proposed to be involved in excitatory effects.<ref>PMID:20525224</ref> Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity.<ref>PMID:16580639</ref> Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity.<ref>PMID:16580639</ref> [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Gati C]]
			[[Category: Han GW]]
			[[Category: Khan S]]

OCA at 05:56, 15 October 2025

2025-10-15T05:56:39Z

← Older revision		Revision as of 05:56, 15 October 2025
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 9py2 is ON HOLD		The entry 9py2 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 05:39, 27 August 2025

2025-08-27T05:39:24Z

← Older revision		Revision as of 05:39, 27 August 2025
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 9py2 is ON HOLD ~~until sometime in the future~~		The entry 9py2 is ON HOLD

	Authors:		Authors:

OCA at 04:53, 20 August 2025

2025-08-20T04:53:41Z

← Older revision		Revision as of 04:53, 20 August 2025
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 9py2 is ON HOLD		The entry 9py2 is ON HOLD until sometime in the future

	Authors:		Authors:

OCA: Protected "9py2" [edit=sysop:move=sysop]

2025-08-13T06:50:07Z

Protected "9py2" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:50, 13 August 2025
(No difference)

OCA: New page: '''Unreleased structure''' The entry 9py2 is ON HOLD Authors: Description: Category: Unreleased Structures

2025-08-13T06:50:06Z

New page: '''Unreleased structure''' The entry 9py2 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 9py2 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]