OCA at 09:27, 15 April 2026

2026-04-15T09:27:54Z

← Older revision		Revision as of 09:27, 15 April 2026
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	~~'''Unreleased structure'''~~

	~~The entry~~ 9qs2 is ~~ON HOLD until Paper Publication~~		==Crystal structure of Zika Virus NS2B-NS3 protease in complex with Z100582766==
			<StructureSection load='9qs2' size='340' side='right'caption='[[9qs2]], [[Resolution\|resolution]] 1.65Å' scene=''>
	~~Authors~~: ~~Benz~~, L.S., ~~Becker~~, F., ~~Janssen~~, P., ~~Fuesser~~, F.T., ~~Weiss,~~ M.S., ~~Kuemmel, D~~., ~~Koch, O~~.		== Structural highlights ==
			<table><tr><td colspan='2'>[[9qs2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Zika_virus Zika virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QS2 FirstGlance]. <br>
	~~Description: Crystal structure of Zika Virus NS2B-NS3 protease in complex with Z100582766~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1I9X:1-methyl-~{N}-(pyridin-2-ylmethyl)pyrazole-4-carboxamide'>A1I9X</scene></td></tr>
	[[Category: ~~Janssen, P~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qs2 OCA], [https://pdbe.org/9qs2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qs2 RCSB], [https://www.ebi.ac.uk/pdbsum/9qs2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qs2 ProSAT]</span></td></tr>
	[[Category: Becker, F]]		</table>
	[[Category: ~~Koch, O~~]]		== Function ==
	[[Category: Fuesser~~, F.T~~]]		[https://www.uniprot.org/uniprot/POLG_ZIKV POLG_ZIKV] Protein C: Encapsulates the genomic RNA.[UniProtKB:P17763] prM: Acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated.[UniProtKB:P17763] Envelope protein E: Binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes.[UniProtKB:P17763] Non-structural protein 1: Involved in virus replication and regulation of the innate immune response.[UniProtKB:P17763] Non-structural protein 2A: May be involved viral RNA replication and capsid assembly.[UniProtKB:P09732] Non-structural protein 4A: Induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the helicase region of Serine protease NS3 chain.[UniProtKB:P17763] Peptide 2k: Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[UniProtKB:P17763] Non-structural protein 4B: Inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway.[UniProtKB:P17763]
	[[Category: ~~Kuemmel, D~~]]		__TOC__
	[[Category: ~~Weiss, M.S~~]]		</StructureSection>
	[[Category: ~~Benz, L.S~~]]		[[Category: Large Structures]]
			[[Category: Zika virus]]
			[[Category: Becker F]]
			[[Category: Benz LS]]
			[[Category: Fuesser FT]]
			[[Category: Janssen P]]
			[[Category: Koch O]]
			[[Category: Kuemmel D]]
			[[Category: Weiss MS]]

OCA at 04:23, 14 May 2025

2025-05-14T04:23:19Z

← Older revision		Revision as of 04:23, 14 May 2025
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 9qs2 is ON HOLD		The entry 9qs2 is ON HOLD until Paper Publication

	Authors: Benz, L.S., Becker, F., Janssen, P., Fuesser, F.T., Weiss, M.S., Kuemmel, D., Koch, O.		Authors: Benz, L.S., Becker, F., Janssen, P., Fuesser, F.T., Weiss, M.S., Kuemmel, D., Koch, O.
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	Description: Crystal structure of Zika Virus NS2B-NS3 protease in complex with Z100582766		Description: Crystal structure of Zika Virus NS2B-NS3 protease in complex with Z100582766
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
			[[Category: Janssen, P]]
			[[Category: Becker, F]]
	[[Category: Koch, O]]		[[Category: Koch, O]]
	~~[[Category: Benz, L.S]]~~
	~~[[Category: Janssen, P]]~~
	~~[[Category: Weiss, M.S]]~~
	[[Category: Fuesser, F.T]]		[[Category: Fuesser, F.T]]
	~~[[Category: Becker, F]]~~
	[[Category: Kuemmel, D]]		[[Category: Kuemmel, D]]
			[[Category: Weiss, M.S]]
			[[Category: Benz, L.S]]

OCA: Protected "9qs2" [edit=sysop:move=sysop]

2025-04-16T09:57:22Z

Protected "9qs2" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:57, 16 April 2025
(No difference)

OCA: New page: '''Unreleased structure''' The entry 9qs2 is ON HOLD Authors: Benz, L.S., Becker, F., Janssen, P., Fuesser, F.T., Weiss, M.S., Kuemmel, D., Koch, O. Description: Crystal structure of Z...

2025-04-16T09:57:21Z

New page: '''Unreleased structure''' The entry 9qs2 is ON HOLD Authors: Benz, L.S., Becker, F., Janssen, P., Fuesser, F.T., Weiss, M.S., Kuemmel, D., Koch, O. Description: Crystal structure of Z...

New page

'''Unreleased structure'''

The entry 9qs2 is ON HOLD

Authors: Benz, L.S., Becker, F., Janssen, P., Fuesser, F.T., Weiss, M.S., Kuemmel, D., Koch, O.

Description: Crystal structure of Zika Virus NS2B-NS3 protease in complex with Z100582766
[[Category: Unreleased Structures]]
[[Category: Koch, O]]
[[Category: Benz, L.S]]
[[Category: Janssen, P]]
[[Category: Weiss, M.S]]
[[Category: Fuesser, F.T]]
[[Category: Becker, F]]
[[Category: Kuemmel, D]]

9qs2 - Revision history

OCA at 09:27, 15 April 2026

OCA at 04:23, 14 May 2025

OCA: Protected "9qs2" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 9qs2 is ON HOLD Authors: Benz, L.S., Becker, F., Janssen, P., Fuesser, F.T., Weiss, M.S., Kuemmel, D., Koch, O. Description: Crystal structure of Z...