OCA at 07:07, 31 December 2025

2025-12-31T07:07:40Z

← Older revision		Revision as of 07:07, 31 December 2025
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	~~'''Unreleased structure'''~~

	~~The entry~~ 9req is ~~ON HOLD until Paper Publication~~		==Crystal Structure of the Protein-Kinase A catalytic subunit from Cricetulus griseus in complex with F310==
			<StructureSection load='9req' size='340' side='right'caption='[[9req]], [[Resolution\|resolution]] 1.50Å' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>[[9req]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9REQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9REQ FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1JEI:1-[[(2~{R},3~{S},6~{S})-6-(2-hydroxyethyl)-3-oxidanyl-oxan-2-yl]methyl]-3-phenyl-urea'>A1JEI</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9req FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9req OCA], [https://pdbe.org/9req PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9req RCSB], [https://www.ebi.ac.uk/pdbsum/9req PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9req ProSAT]</span></td></tr>
			</table>
			== Function ==
			[https://www.uniprot.org/uniprot/KAPCA_CRIGR KAPCA_CRIGR] Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA (By similarity).
			__TOC__
			</StructureSection>
			[[Category: Cricetulus griseus]]
			[[Category: Large Structures]]
			[[Category: Glinca S]]
			[[Category: Klebe G]]
			[[Category: Mueller JM]]
			[[Category: Wolter M]]

OCA at 15:08, 9 July 2025

2025-07-09T15:08:58Z

← Older revision		Revision as of 15:08, 9 July 2025
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 9req is ON HOLD		The entry 9req is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "9req" [edit=sysop:move=sysop]

2025-06-18T09:30:03Z

Protected "9req" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:30, 18 June 2025
(No difference)

OCA: New page: '''Unreleased structure''' The entry 9req is ON HOLD Authors: Description: Category: Unreleased Structures

2025-06-18T09:30:01Z

New page: '''Unreleased structure''' The entry 9req is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 9req is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

9req - Revision history

OCA at 07:07, 31 December 2025

OCA at 15:08, 9 July 2025

OCA: Protected "9req" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 9req is ON HOLD Authors: Description: Category: Unreleased Structures