9rtb - Revision history

OCA at 07:06, 15 July 2026

2026-07-15T07:06:39Z

← Older revision		Revision as of 07:06, 15 July 2026
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	~~'''Unreleased structure'''~~

	~~The entry 9rtb is ON HOLD until Paper Publication~~		==Crystal structure of the adduct formed upon reaction of [V(IV)O(acetylacetonate)2] with human serum transferrin with Fe(III) bound at the C-lobe only==
			<StructureSection load='9rtb' size='340' side='right'caption='[[9rtb]], [[Resolution\|resolution]] 1.93Å' scene=''>
	~~Authors: Paolillo, M., Ferraro, G., Banneville, A.S., Cornaciu, I., Pica, A., Merlino, A.~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[9rtb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RTB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RTB FirstGlance]. <br>
	~~Description:~~ Crystal structure of the adduct formed upon reaction of [V(IV)O(acetylacetonate)2] with human serum transferrin with Fe(III) bound at the C-lobe only		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.93Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1JJT:bis(oxidanyl)-oxidanylidene-(oxidanyl(oxidanylidene)vanadio)oxy-vanadium'>A1JJT</scene>, <scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
	[[Category: ~~Ferraro, G~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rtb OCA], [https://pdbe.org/9rtb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rtb RCSB], [https://www.ebi.ac.uk/pdbsum/9rtb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rtb ProSAT]</span></td></tr>
	[[Category: Cornaciu, I]]		</table>
	[[Category: ~~Banneville, A.S~~]]		== Disease ==
	[[Category: ~~Pica,~~ A]]		[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
	[[Category: ~~Merlino, A~~]]		== Function ==
	[[Category: ~~Paolillo, M~~]]		[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Banneville AS]]
			[[Category: Cornaciu I]]
			[[Category: Ferraro G]]
			[[Category: Merlino A]]
			[[Category: Paolillo M]]
			[[Category: Pica A]]

OCA at 04:33, 16 July 2025

2025-07-16T04:33:23Z

← Older revision		Revision as of 04:33, 16 July 2025
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 9rtb is ON HOLD		The entry 9rtb is ON HOLD until Paper Publication

	Authors: Paolillo, M., Ferraro, G., Banneville, A.S., Cornaciu, I., Pica, A., Merlino, A.		Authors: Paolillo, M., Ferraro, G., Banneville, A.S., Cornaciu, I., Pica, A., Merlino, A.

	Description: Crystal structure of the adduct formed upon reaction of [V(IV)O(acetylacetonate)~~Ã¢ââ~~] with human serum transferrin with Fe(III) bound at the C-lobe only		Description: Crystal structure of the adduct formed upon reaction of [V(IV)O(acetylacetonate)2] with human serum transferrin with Fe(III) bound at the C-lobe only
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
			[[Category: Ferraro, G]]
	[[Category: Cornaciu, I]]		[[Category: Cornaciu, I]]
			[[Category: Banneville, A.S]]
			[[Category: Pica, A]]
			[[Category: Merlino, A]]
	[[Category: Paolillo, M]]		[[Category: Paolillo, M]]
	~~[[Category: Merlino, A]]~~
	~~[[Category: Ferraro, G]]~~
	~~[[Category: Pica, A]]~~
	~~[[Category: Banneville, A.S]]~~

OCA: Protected "9rtb" [edit=sysop:move=sysop]

2025-07-09T15:14:59Z

Protected "9rtb" [edit=sysop:move=sysop]

← Older revision	Revision as of 15:14, 9 July 2025
(No difference)

OCA: New page: '''Unreleased structure''' The entry 9rtb is ON HOLD Authors: Paolillo, M., Ferraro, G., Banneville, A.S., Cornaciu, I., Pica, A., Merlino, A. Description: Crystal structure of the add...

2025-07-09T15:14:58Z

New page: '''Unreleased structure''' The entry 9rtb is ON HOLD Authors: Paolillo, M., Ferraro, G., Banneville, A.S., Cornaciu, I., Pica, A., Merlino, A. Description: Crystal structure of the add...

New page

'''Unreleased structure'''

The entry 9rtb is ON HOLD

Authors: Paolillo, M., Ferraro, G., Banneville, A.S., Cornaciu, I., Pica, A., Merlino, A.

Description: Crystal structure of the adduct formed upon reaction of [V(IV)O(acetylacetonate)Ã¢ââ] with human serum transferrin with Fe(III) bound at the C-lobe only
[[Category: Unreleased Structures]]
[[Category: Cornaciu, I]]
[[Category: Paolillo, M]]
[[Category: Merlino, A]]
[[Category: Ferraro, G]]
[[Category: Pica, A]]
[[Category: Banneville, A.S]]