9ugg - Revision history

OCA at 09:32, 15 April 2026

2026-04-15T09:32:57Z

← Older revision		Revision as of 09:32, 15 April 2026
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	~~'''Unreleased structure'''~~

	~~The entry~~ 9ugg is ~~ON HOLD until Paper~~ Publication		==PsdAB dimer (peptidisc sample)==
			<StructureSection load='9ugg' size='340' side='right'caption='[[9ugg]], [[Resolution\|resolution]] 3.60Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[9ugg]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Unclassified_Bacillus_(in:_Bacteria) Unclassified Bacillus (in: Bacteria)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UGG FirstGlance]. <br>
			</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.6Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ugg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ugg OCA], [https://pdbe.org/9ugg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ugg RCSB], [https://www.ebi.ac.uk/pdbsum/9ugg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ugg ProSAT]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Bacteria have evolved diverse strategies to resist antimicrobial peptides, among them lipid II-targeting lantibiotics such as nisin. PsdAB, an ABC-type transporter regulated by the PsdRS two-component system, contributes to nisin resistance, though its structural and mechanistic basis have remained unclear. Here, we report the cryo-EM structure of Bacillus subtilis PsdAB, revealing a dimeric assembly with an unusually large central cavity at the TMD interface. Cross-linking studies confirm the dimeric nature of PsdAB both in vitro and in cells. Functional assays demonstrate that dimer-disrupting mutations compromise nisin resistance, highlighting the importance of dimerization for activity. Compared to canonical ABC transporter types, PsdAB adopts an atypical architecture comprising four NBDs and two TMDs arranged around a central cavity, which may accommodate lipid II. We propose that PsdAB represents a previously unrecognized ABC transporter class. These findings offer new insights into transporter-mediated lantibiotic resistance and suggest a potential mechanism of lipid II shielding.

	~~Authors:~~ He, Y~~.T.~~, Fan, W.J., Shao, K., Luo, M.		Cryo-EM structure of the Nisin resistance pump PsdAB reveals an unusual ABC transporter architecture.,He Y, Fan W, Shi J, Gan BK, Shao K, Zhu F, Hong X, Luo M Structure. 2026 Feb 5;34(2):311-321.e5. doi: 10.1016/j.str.2025.11.013. Epub 2025 , Dec 18. PMID:41418778<ref>PMID:41418778</ref>

	~~Description~~: ~~PsdAB dimer (peptidisc sample)~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	[[Category: ~~Unreleased~~ Structures]]		</div>
	[[Category: ~~He, Y.T~~]]		<div class="pdbe-citations 9ugg" style="background-color:#fffaf0;"></div>
	[[Category: ~~Fan, W.J~~]]		== References ==
	[[Category: ~~Shao, K~~]]		<references/>
	[[Category: ~~Luo, M~~]]		__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Fan WJ]]
			[[Category: He YT]]
			[[Category: Luo M]]
			[[Category: Shao K]]

OCA at 06:14, 12 November 2025

2025-11-12T06:14:31Z

← Older revision		Revision as of 06:14, 12 November 2025
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 9ugg is ON HOLD		The entry 9ugg is ON HOLD until Paper Publication

	Authors: He, Y.T., Fan, W.J., Shao, K., Luo, M.		Authors: He, Y.T., Fan, W.J., Shao, K., Luo, M.
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	Description: PsdAB dimer (peptidisc sample)		Description: PsdAB dimer (peptidisc sample)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
			[[Category: He, Y.T]]
	[[Category: Fan, W.J]]		[[Category: Fan, W.J]]
	[[Category: He, ~~Y.T~~]]		[[Category: Shao, K]]
	[[Category: Luo, M]]		[[Category: Luo, M]]
	~~[[Category: Shao, K]]~~

OCA at 06:04, 15 October 2025

2025-10-15T06:04:11Z

← Older revision		Revision as of 06:04, 15 October 2025
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 9ugg is ON HOLD ~~until Paper Publication~~		The entry 9ugg is ON HOLD

	Authors: He, Y.T., Fan, W.J., Shao, K., Luo, M.		Authors: He, Y.T., Fan, W.J., Shao, K., Luo, M.

	Description: PsdAB dimer		Description: PsdAB dimer (peptidisc sample)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	~~[[Category: Luo, M]]~~
	[[Category: Fan, W.J]]		[[Category: Fan, W.J]]
	[[Category: He, Y.T]]		[[Category: He, Y.T]]
			[[Category: Luo, M]]
	[[Category: Shao, K]]		[[Category: Shao, K]]

OCA at 09:40, 18 June 2025

2025-06-18T09:40:11Z

← Older revision		Revision as of 09:40, 18 June 2025
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 9ugg is ON HOLD		The entry 9ugg is ON HOLD until Paper Publication

	Authors: He, Y.T., Fan, W.J., Shao, K., Luo, M.		Authors: He, Y.T., Fan, W.J., Shao, K., Luo, M.
Line 7:		Line 7:
	Description: PsdAB dimer		Description: PsdAB dimer
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
			[[Category: Luo, M]]
			[[Category: Fan, W.J]]
	[[Category: He, Y.T]]		[[Category: He, Y.T]]
	[[Category: Shao, K]]		[[Category: Shao, K]]
	~~[[Category: Luo, M]]~~
	~~[[Category: Fan, W.J]]~~

OCA: Protected "9ugg" [edit=sysop:move=sysop]

2025-04-23T04:20:59Z

Protected "9ugg" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:20, 23 April 2025
(No difference)

OCA: New page: '''Unreleased structure''' The entry 9ugg is ON HOLD Authors: He, Y.T., Fan, W.J., Shao, K., Luo, M. Description: PsdAB dimer Category: Unreleased Structures Category: He, Y.T ...

2025-04-23T04:20:58Z

New page: '''Unreleased structure''' The entry 9ugg is ON HOLD Authors: He, Y.T., Fan, W.J., Shao, K., Luo, M. Description: PsdAB dimer Category: Unreleased Structures Category: He, Y.T ...

New page

'''Unreleased structure'''

The entry 9ugg is ON HOLD

Authors: He, Y.T., Fan, W.J., Shao, K., Luo, M.

Description: PsdAB dimer
[[Category: Unreleased Structures]]
[[Category: He, Y.T]]
[[Category: Shao, K]]
[[Category: Luo, M]]
[[Category: Fan, W.J]]