OCA at 15:13, 10 June 2026

2026-06-10T15:13:39Z

← Older revision		Revision as of 15:13, 10 June 2026
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	~~'''Unreleased structure'''~~

	~~The entry 9v4e is ON HOLD until Paper Publication~~		==Crystal Structure of Gallus gallus c-Src Kinase Domain with Point mutation Y416D and Deletion of Residues N414, T417, and R419 Bound to AMP-PNP==
			<StructureSection load='9v4e' size='340' side='right'caption='[[9v4e]], [[Resolution\|resolution]] 1.78Å' scene=''>
	~~Authors: Jain, P., Clifton, B.E., Laurino, P.~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[9v4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9V4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9V4E FirstGlance]. <br>
	~~Description:~~ Crystal Structure of Gallus gallus c-Src Kinase Domain with Point mutation Y416D and Deletion of Residues N414, T417, and R419 Bound to AMP-PNP		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.78Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	[[Category: Clifton~~, B.E~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9v4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9v4e OCA], [https://pdbe.org/9v4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9v4e RCSB], [https://www.ebi.ac.uk/pdbsum/9v4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9v4e ProSAT]</span></td></tr>
	[[Category: ~~Laurino,~~ P]]		</table>
	[[Category: ~~Jain,~~ P]]		== Function ==
			[https://www.uniprot.org/uniprot/SRC_CHICK SRC_CHICK] Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates involved in this process. When cells adhere via focal adhesions to the extra-cellular matrix, signals are transmitted by integrins into the cell and result in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN). Also active at the sites of cell-cell contact adherens junctions and at gap junctions. Implicated in the regulation of pre-mRNA-processing. Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus.<ref>PMID:1717492</ref> <ref>PMID:8550628</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Gallus gallus]]
			[[Category: Large Structures]]
			[[Category: Clifton BE]]
			[[Category: Jain P]]
			[[Category: Laurino P]]

OCA at 07:18, 4 June 2025

2025-06-04T07:18:13Z

← Older revision		Revision as of 07:18, 4 June 2025
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 9v4e is ON HOLD		The entry 9v4e is ON HOLD until Paper Publication

	Authors: Jain, P., Clifton, B.E., Laurino, P.		Authors: Jain, P., Clifton, B.E., Laurino, P.

	Description: Crystal Structure of ~~Human~~ c-Src Kinase Domain with Point mutation Y416D and Deletion of Residues N414, T417, and R419 Bound to AMP-PNP		Description: Crystal Structure of Gallus gallus c-Src Kinase Domain with Point mutation Y416D and Deletion of Residues N414, T417, and R419 Bound to AMP-PNP
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
			[[Category: Clifton, B.E]]
			[[Category: Laurino, P]]
	[[Category: Jain, P]]		[[Category: Jain, P]]
	~~[[Category: Laurino, P]]~~
	~~[[Category: Clifton, B.E]]~~

OCA: Protected "9v4e" [edit=sysop:move=sysop]

2025-05-28T04:40:04Z

Protected "9v4e" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:40, 28 May 2025
(No difference)

OCA: New page: '''Unreleased structure''' The entry 9v4e is ON HOLD Authors: Jain, P., Clifton, B.E., Laurino, P. Description: Crystal Structure of Human c-Src Kinase Domain with Point mutation Y416D...

2025-05-28T04:40:03Z

New page: '''Unreleased structure''' The entry 9v4e is ON HOLD Authors: Jain, P., Clifton, B.E., Laurino, P. Description: Crystal Structure of Human c-Src Kinase Domain with Point mutation Y416D...

New page

'''Unreleased structure'''

The entry 9v4e is ON HOLD

Authors: Jain, P., Clifton, B.E., Laurino, P.

Description: Crystal Structure of Human c-Src Kinase Domain with Point mutation Y416D and Deletion of Residues N414, T417, and R419 Bound to AMP-PNP
[[Category: Unreleased Structures]]
[[Category: Jain, P]]
[[Category: Laurino, P]]
[[Category: Clifton, B.E]]

9v4e - Revision history

OCA at 15:13, 10 June 2026

OCA at 07:18, 4 June 2025

OCA: Protected "9v4e" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 9v4e is ON HOLD Authors: Jain, P., Clifton, B.E., Laurino, P. Description: Crystal Structure of Human c-Src Kinase Domain with Point mutation Y416D...