9vec - Revision history

OCA at 06:25, 20 August 2025

2025-08-20T06:25:16Z

← Older revision		Revision as of 06:25, 20 August 2025
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	~~'''Unreleased structure'''~~

	~~The entry~~ 9vec is ~~ON HOLD until Paper Publication~~		==structure of human KCNQ1-KCNE1-CaM complex==
			<StructureSection load='9vec' size='340' side='right'caption='[[9vec]], [[Resolution\|resolution]] 2.70Å' scene=''>
	~~Authors~~: ~~Cui~~, C., ~~Kermani~~, A., ~~Cui~~, J.~~, Sun, J~~.		== Structural highlights ==
			<table><tr><td colspan='2'>[[9vec]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VEC FirstGlance]. <br>
	~~Description~~: ~~structure~~ of ~~human KCNQ1~~-~~KCNE1~~-~~CaM~~ complex		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.7Å</td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	[[Category: Cui~~, J~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vec OCA], [https://pdbe.org/9vec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vec RCSB], [https://www.ebi.ac.uk/pdbsum/9vec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vec ProSAT]</span></td></tr>
	[[Category: Cui~~, C~~]]		</table>
	[[Category: Kermani, A]]		== Disease ==
	[[Category: Sun, J]]		[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
			== Function ==
			[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Cui C]]
			[[Category: Cui J]]
			[[Category: Kermani A]]
			[[Category: Sun J]]

OCA at 05:06, 23 July 2025

2025-07-23T05:06:58Z

← Older revision		Revision as of 05:06, 23 July 2025
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 9vec is ON HOLD		The entry 9vec is ON HOLD until Paper Publication

	Authors: Cui, C., Kermani, A., Cui, J., Sun, J.		Authors: Cui, C., Kermani, A., Cui, J., Sun, J.
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	Description: structure of human KCNQ1-KCNE1-CaM complex		Description: structure of human KCNQ1-KCNE1-CaM complex
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
			[[Category: Cui, J]]
			[[Category: Cui, C]]
	[[Category: Kermani, A]]		[[Category: Kermani, A]]
	[[Category: Sun, J]]		[[Category: Sun, J]]
	~~[[Category: Cui, C]]~~
	~~[[Category: Cui, J]]~~

OCA: Protected "9vec" [edit=sysop:move=sysop]

2025-06-18T09:54:48Z

Protected "9vec" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:54, 18 June 2025
(No difference)

OCA: New page: '''Unreleased structure''' The entry 9vec is ON HOLD Authors: Cui, C., Kermani, A., Cui, J., Sun, J. Description: structure of human KCNQ1-KCNE1-CaM complex [[Category: Unreleased Stru...

2025-06-18T09:54:48Z

New page: '''Unreleased structure''' The entry 9vec is ON HOLD Authors: Cui, C., Kermani, A., Cui, J., Sun, J. Description: structure of human KCNQ1-KCNE1-CaM complex [[Category: Unreleased Stru...

New page

'''Unreleased structure'''

The entry 9vec is ON HOLD

Authors: Cui, C., Kermani, A., Cui, J., Sun, J.

Description: structure of human KCNQ1-KCNE1-CaM complex
[[Category: Unreleased Structures]]
[[Category: Kermani, A]]
[[Category: Sun, J]]
[[Category: Cui, C]]
[[Category: Cui, J]]