OCA at 16:54, 8 September 2026

2026-09-08T16:54:36Z

← Older revision		Revision as of 16:54, 8 September 2026
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	~~'''Unreleased structure'''~~

	~~The entry~~ 9wpf is ~~ON HOLD~~		==Cryo-EM structure of the insect sex pheromone receptor ApisOR22-Orco heterocomplex==
			<StructureSection load='9wpf' size='340' side='right'caption='[[9wpf]], [[Resolution\|resolution]] 3.60Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[9wpf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Acyrthosiphon_pisum Acyrthosiphon pisum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WPF FirstGlance]. <br>
			</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.6Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9wpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wpf OCA], [https://pdbe.org/9wpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wpf RCSB], [https://www.ebi.ac.uk/pdbsum/9wpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wpf ProSAT]</span></td></tr>
			</table>
			== Function ==
			[https://www.uniprot.org/uniprot/A0A8R2JM50_ACYPI A0A8R2JM50_ACYPI]
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Sex pheromones play a central role in regulating animal behavior and reproduction. In insects, these signals are perceived through specialized odorant receptors (ORs) that mediate species-specific communication and safeguard genetic integrity. However, the structural basis of sex pheromone detection remains largely unresolved. Here, we identified two ORs in the pea aphid Acyrthosiphon pisum, along with the conserved OR co-receptor (Orco), which together mediate recognition of the pheromone components nepetalactone and nepetalactol. Functional assays demonstrated that ApOR21-Orco and ApOR22-Orco specifically respond to nepetalactol and nepetalactone, respectively. Using cryo-electron microscopy, we resolved the structure of the ApOR22-Orco complex in three states - unbound closed, nepetalactone-bound closed, and nepetalactone-bound open - revealing a heterotetrameric ion channel formed by one ApOR22 and three ApOrco subunits. Ligand binding to ApOR22 triggers conformational rearrangements that induce asymmetric pore dilation, thereby enabling ion conduction. Together, these results provide a mechanistic framework for understanding sex pheromone perception in insects and establish a structural foundation for the rational development of environmentally sustainable pest-control strategies.

	~~Authors:~~ Dong, Z., Wang, Y~~.D.~~, Guan, Z~~.Y.~~, Wang, G.R., ~~Yin, P~~.		Structural basis of sex pheromone detection in aphids.,Dong Z, Wang Y, Tian Y, Guan Z, Bai M, Zhang B, Jia Z, Wu J, Cao S, Gong Z, Zhao X, Ma W, Wang B, Wang G, Yin P Cell Res. 2026 Aug;36(8):582-594. doi: 10.1038/s41422-026-01267-z. Epub 2026 Jun , 22. PMID:42332065<ref>PMID:42332065</ref>

	~~Description: Cryo-EM structure~~ of the ~~insect sex pheromone receptor ApisOR22~~-~~Orco heterocomplex~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	[[Category: ~~Unreleased~~ Structures]]		</div>
	[[Category: Dong, Z]]		<div class="pdbe-citations 9wpf" style="background-color:#fffaf0;"></div>
	[[Category: Guan~~, Z.Y~~]]		== References ==
	[[Category: ~~Yin, P~~]]		<references/>
	[[Category: Wang~~, Y.D~~]]		__TOC__
	[[Category: ~~Wang, G.R~~]]		</StructureSection>
			[[Category: Acyrthosiphon pisum]]
			[[Category: Large Structures]]
			[[Category: Dong Z]]
			[[Category: Guan ZY]]
			[[Category: Wang GR]]
			[[Category: Wang YD]]
			[[Category: Yin P]]

OCA: Protected "9wpf" [edit=sysop:move=sysop]

2025-09-17T04:39:53Z

Protected "9wpf" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:39, 17 September 2025
(No difference)

OCA: New page: '''Unreleased structure''' The entry 9wpf is ON HOLD Authors: Dong, Z., Wang, Y.D., Guan, Z.Y., Wang, G.R., Yin, P. Description: Cryo-EM structure of the insect sex pheromone receptor ...

2025-09-17T04:39:52Z

New page: '''Unreleased structure''' The entry 9wpf is ON HOLD Authors: Dong, Z., Wang, Y.D., Guan, Z.Y., Wang, G.R., Yin, P. Description: Cryo-EM structure of the insect sex pheromone receptor ...

New page

'''Unreleased structure'''

The entry 9wpf is ON HOLD

Authors: Dong, Z., Wang, Y.D., Guan, Z.Y., Wang, G.R., Yin, P.

Description: Cryo-EM structure of the insect sex pheromone receptor ApisOR22-Orco heterocomplex
[[Category: Unreleased Structures]]
[[Category: Dong, Z]]
[[Category: Guan, Z.Y]]
[[Category: Yin, P]]
[[Category: Wang, Y.D]]
[[Category: Wang, G.R]]

9wpf - Revision history

OCA at 16:54, 8 September 2026

OCA: Protected "9wpf" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 9wpf is ON HOLD Authors: Dong, Z., Wang, Y.D., Guan, Z.Y., Wang, G.R., Yin, P. Description: Cryo-EM structure of the insect sex pheromone receptor ...