OCA at 08:46, 16 September 2026

2026-09-16T08:46:52Z

← Older revision		Revision as of 08:46, 16 September 2026
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	~~'''Unreleased structure'''~~

	The entry ~~9xtj~~ is ~~ON HOLD until 2027~~-11-22		==Overall structure of the human UBR4-KCMF1-Calmodulin complex==
			<StructureSection load='9xtj' size='340' side='right'caption='[[9xtj]], [[Resolution\|resolution]] 3.89Å' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>[[9xtj]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9XTJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9XTJ FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.89Å</td></tr>
	[[Category: ~~Unreleased Structures~~]]		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9xtj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9xtj OCA], [https://pdbe.org/9xtj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9xtj RCSB], [https://www.ebi.ac.uk/pdbsum/9xtj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9xtj ProSAT]</span></td></tr>
			</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/UBR4_HUMAN UBR4_HUMAN] The gene represented in this entry may be involved in disease pathogenesis.
			== Function ==
			[https://www.uniprot.org/uniprot/UBR4_HUMAN UBR4_HUMAN] E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886).<ref>PMID:16214886</ref> <ref>PMID:23932781</ref> <ref>PMID:25582440</ref> <ref>PMID:29033132</ref> <ref>PMID:34893540</ref> <ref>PMID:37891180</ref> <ref>PMID:38030679</ref> <ref>PMID:38182926</ref> <ref>PMID:38297121</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Homo sapiens]]
			[[Category: Large Structures]]
			[[Category: Hu Z]]
			[[Category: Yan R]]

OCA at 07:36, 9 September 2026

2026-09-09T07:36:04Z

← Older revision		Revision as of 07:36, 9 September 2026
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 9xtj is ON HOLD		The entry 9xtj is ON HOLD until 2027-11-22

	Authors:		Authors:

OCA: Protected "9xtj" [edit=sysop:move=sysop]

2025-12-04T17:38:09Z

Protected "9xtj" [edit=sysop:move=sysop]

← Older revision	Revision as of 17:38, 4 December 2025
(No difference)

OCA: New page: '''Unreleased structure''' The entry 9xtj is ON HOLD Authors: Description: Category: Unreleased Structures

2025-12-04T17:38:08Z

New page: '''Unreleased structure''' The entry 9xtj is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 9xtj is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

9xtj - Revision history

OCA at 08:46, 16 September 2026

OCA at 07:36, 9 September 2026

OCA: Protected "9xtj" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 9xtj is ON HOLD Authors: Description: Category: Unreleased Structures