Apoptotic protease-activating factor - Revision history

Michal Harel at 08:54, 9 October 2022

2022-10-09T08:54:13Z

← Older revision		Revision as of 08:54, 9 October 2022
Line 4:		Line 4:
	== Function ==		== Function ==

	'''Apoptosis protease-activating factor-1''' (APAF-1) binds to cytochrome c and ATP to form the apoptosome which leads to the recruitment and activation of caspase 9 by cleaving the procaspase 9. Caspase 9 is involved in executing the apoptosis of cells<ref>PMID:15829969</ref>.		'''Apoptosis protease-activating factor-1''' or '''Apoptosis peptidase-activating factor-1''' (APAF-1) binds to cytochrome c and ATP to form the apoptosome which leads to the recruitment and activation of caspase 9 by cleaving the procaspase 9. Caspase 9 is involved in executing the apoptosis of cells<ref>PMID:15829969</ref>.

	== Disease ==		== Disease ==

2019-03-18T09:13:55Z

← Older revision		Revision as of 09:13, 18 March 2019
Line 19:		Line 19:

	</StructureSection>		</StructureSection>

	~~==3D structures of apoptotic protease-activating factor-1==~~
	~~Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}~~

	~~[[2ygs]], [[1cy5]], [[2p1h]] – hAPAF-1 CARD domain – human <br />~~
	~~[[1c15]], [[1cww]] – hAPAF-1 CARD domain – NMR <br />~~
	~~[[1z6t]] – hAPAF-1 + ADP <br />~~
	~~[[3ygs]] – hAPAF-1 CARD domain + procaspase 9 <br />~~
	~~[[4rhw]], [[5wvc]] – hAPAF-1 CARD domain + caspase 9 <br />~~
	~~[[3j2t]], [[3jbt]] – hAPAF-1 + cytochrome c<br />~~
	~~[[5juy]], [[5wve]] – hAPAF-1 + caspase 9 + cytochrome c<br />~~
	~~[[3sfz]] – mAPAF-1 + ADP - mouse <br />~~
	~~[[3shf]] – mAPAF-1 (mutant) + ADP <br />~~

	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

2019-03-18T09:13:04Z

← Older revision		Revision as of 09:13, 18 March 2019
Line 14:		Line 14:
	Apaf-1 contains several copies of the WD-40 domain which are involved in binding to cytochrome c<ref>PMID:26014357</ref>., caspase recruitment domain (CARD) and an ATPase domain.		Apaf-1 contains several copies of the WD-40 domain which are involved in binding to cytochrome c<ref>PMID:26014357</ref>., caspase recruitment domain (CARD) and an ATPase domain.
	*<scene name='77/774059/Cv/3'>Apoptosome</scene> formed by Human apoptosis protease-activating factor-1 (green; subunits A, B, C, D, E, F, G) complex with cytochrome c (red; subunits H, I, J, K, L, M, N) and caspase 9 (magenta; subunits O, P, Q, R) (PDB entry [[5juy]]).		*<scene name='77/774059/Cv/3'>Apoptosome</scene> formed by Human apoptosis protease-activating factor-1 (green; subunits A, B, C, D, E, F, G) complex with cytochrome c (red; subunits H, I, J, K, L, M, N) and caspase 9 (magenta; subunits O, P, Q, R) (PDB entry [[5juy]]).

			==3D structures of apoptotic protease-activating factor-1==
			[[Apoptotic protease-activating factor-1 3D structures]]

	</StructureSection>		</StructureSection>

2018-03-15T10:14:04Z

← Older revision		Revision as of 10:14, 15 March 2018
Line 16:		Line 16:
	</StructureSection>		</StructureSection>

	==3D structures of ~~apoptosis~~ protease-activating factor-1==		==3D structures of apoptotic protease-activating factor-1==
	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

2018-03-15T10:11:14Z

← Older revision		Revision as of 10:11, 15 March 2018
Line 26:		Line 26:
	[[3j2t]], [[3jbt]] – hAPAF-1 + cytochrome c<br />		[[3j2t]], [[3jbt]] – hAPAF-1 + cytochrome c<br />
	[[5juy]], [[5wve]] – hAPAF-1 + caspase 9 + cytochrome c<br />		[[5juy]], [[5wve]] – hAPAF-1 + caspase 9 + cytochrome c<br />
			[[3sfz]] – mAPAF-1 + ADP - mouse <br />
			[[3shf]] – mAPAF-1 (mutant) + ADP <br />

	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

2018-03-04T14:20:03Z

← Older revision		Revision as of 14:20, 4 March 2018
Line 13:		Line 13:

	Apaf-1 contains several copies of the WD-40 domain which are involved in binding to cytochrome c<ref>PMID:26014357</ref>., caspase recruitment domain (CARD) and an ATPase domain.		Apaf-1 contains several copies of the WD-40 domain which are involved in binding to cytochrome c<ref>PMID:26014357</ref>., caspase recruitment domain (CARD) and an ATPase domain.
	*<scene name='77/774059/Cv/3'>Apoptosome</scene> formed by Human apoptosis protease-activating factor-1 (green; subunits A, B, C, D, E, F, G) complex with cytochrome c (red; H, I, J, K, L, M, N) and caspase 9 (magenta; O, P, Q, R) (PDB entry [[5juy]]).		*<scene name='77/774059/Cv/3'>Apoptosome</scene> formed by Human apoptosis protease-activating factor-1 (green; subunits A, B, C, D, E, F, G) complex with cytochrome c (red; subunits H, I, J, K, L, M, N) and caspase 9 (magenta; subunits O, P, Q, R) (PDB entry [[5juy]]).
	</StructureSection>		</StructureSection>

2018-03-04T14:08:12Z

← Older revision		Revision as of 14:08, 4 March 2018
Line 1:		Line 1:
	<StructureSection load='5juy' size='340' side='right' caption='Human apoptosis protease-activating factor-1 ~~(green)~~ complex with cytochrome c ~~(red)~~ and caspase 9 ~~(magenta)~~ forming the apoptosome (PDB entry [[5juy]]) ' scene='77/774059/Cv/2'>		<StructureSection load='5juy' size='340' side='right' caption='Human apoptosis protease-activating factor-1 complex with cytochrome c and caspase 9 forming the apoptosome (PDB entry [[5juy]]) ' scene='77/774059/Cv/2'>

2018-03-04T14:07:23Z

← Older revision		Revision as of 14:07, 4 March 2018
Line 13:		Line 13:

	Apaf-1 contains several copies of the WD-40 domain which are involved in binding to cytochrome c<ref>PMID:26014357</ref>., caspase recruitment domain (CARD) and an ATPase domain.		Apaf-1 contains several copies of the WD-40 domain which are involved in binding to cytochrome c<ref>PMID:26014357</ref>., caspase recruitment domain (CARD) and an ATPase domain.
			*<scene name='77/774059/Cv/3'>Apoptosome</scene> formed by Human apoptosis protease-activating factor-1 (green; subunits A, B, C, D, E, F, G) complex with cytochrome c (red; H, I, J, K, L, M, N) and caspase 9 (magenta; O, P, Q, R) (PDB entry [[5juy]]).
	</StructureSection>		</StructureSection>

2018-03-04T13:58:14Z

← Older revision		Revision as of 13:58, 4 March 2018
Line 1:		Line 1:
	<StructureSection load='5juy' size='340' side='right' caption='Human apoptosis protease-activating factor-1 (~~grey~~) complex with cytochrome c (red) and caspase 9 (~~pale blue~~) forming the apoptosome (PDB entry [[5juy]]) ' scene='77/774059/Cv/1'>		<StructureSection load='5juy' size='340' side='right' caption='Human apoptosis protease-activating factor-1 (green) complex with cytochrome c (red) and caspase 9 (magenta) forming the apoptosome (PDB entry [[5juy]]) ' scene='77/774059/Cv/2'>

2018-03-04T13:51:32Z

← Older revision		Revision as of 13:51, 4 March 2018
Line 1:		Line 1:
	<StructureSection load='5juy' size='340' side='right' caption='Human apoptosis protease-activating factor-1 (grey) complex with cytochrome c (red) and caspase 9 (pale blue) forming the apoptosome (PDB entry [[5juy]]) ' scene=''>		<StructureSection load='5juy' size='340' side='right' caption='Human apoptosis protease-activating factor-1 (grey) complex with cytochrome c (red) and caspase 9 (pale blue) forming the apoptosome (PDB entry [[5juy]]) ' scene='77/774059/Cv/1'>