CD3 - Revision history

Michal Harel at 09:10, 30 April 2019

2019-04-30T09:10:37Z

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 </StructureSection>
 == References ==
 <references/>
 [[Category: Topic Page]]

Michal Harel at 09:09, 30 April 2019

2019-04-30T09:09:31Z

← Older revision		Revision as of 09:09, 30 April 2019
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	Drugs which bind to CD3 are tested as immunorepressants.		Drugs which bind to CD3 are tested as immunorepressants.

			==3D structures of CD3==
			[[CD3 3D structures]]

	</StructureSection>		</StructureSection>

Michal Harel at 09:18, 6 December 2015

2015-12-06T09:18:29Z

← Older revision		Revision as of 09:18, 6 December 2015
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	== Function ==		== Function ==

	'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single Immunorecetor Tyrosine-based Activation Motif (ITAM). <ref>PMID:24488493</ref>		'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single Immunorecetor Tyrosine-based Activation Motif (ITAM). <ref>PMID:24488493</ref><ref>PMID:15136729</ref>
	*<scene name='55/551236/Cv/2'>Human CD3 extracellular domain with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]).		*<scene name='55/551236/Cv/2'>Human CD3 extracellular domain with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]).

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	Drugs which bind to CD3 are tested as immunorepressants.		Drugs which bind to CD3 are tested as immunorepressants.
	~~<ref>PMID:15136729</ref>~~
	</StructureSection>		</StructureSection>
	==3D structures of CD3==		==3D structures of CD3==

Michal Harel at 09:17, 6 December 2015

2015-12-06T09:17:04Z

← Older revision		Revision as of 09:17, 6 December 2015
Line 10:		Line 10:
	Drugs which bind to CD3 are tested as immunorepressants.		Drugs which bind to CD3 are tested as immunorepressants.
	<ref>PMID:15136729</ref>		<ref>PMID:15136729</ref>
			</StructureSection>
	==3D structures of CD3==		==3D structures of CD3==

Alexander Berchansky at 12:28, 29 November 2015

2015-11-29T12:28:11Z

← Older revision		Revision as of 12:28, 29 November 2015
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	<StructureSection load='1sy6' size='~~450~~' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'>		<StructureSection load='1sy6' size='350' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'>

	== Function ==		== Function ==

Alexander Berchansky at 10:59, 29 November 2015

2015-11-29T10:59:57Z

← Older revision		Revision as of 10:59, 29 November 2015
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	<StructureSection load='1sy6' size='450' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'>		<StructureSection load='1sy6' size='450' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'>
	~~</StructureSection>~~
	~~__TOC__~~

	== Function ==		== Function ==

Michal Harel at 07:58, 29 November 2015

2015-11-29T07:58:59Z

← Older revision		Revision as of 07:58, 29 November 2015
Line 12:		Line 12:
	Drugs which bind to CD3 are tested as immunorepressants.		Drugs which bind to CD3 are tested as immunorepressants.
	<ref>PMID:15136729</ref>		<ref>PMID:15136729</ref>
	~~</StructureSection>~~

	==3D structures of CD3==		==3D structures of CD3==

Michal Harel at 07:58, 29 November 2015

2015-11-29T07:58:00Z

← Older revision		Revision as of 07:58, 29 November 2015
Line 1:		Line 1:
	<StructureSection load='1sy6' size='450' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'>		<StructureSection load='1sy6' size='450' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'>
			</StructureSection>
			__TOC__

	== Function ==		== Function ==

Michal Harel at 09:45, 24 November 2015

2015-11-24T09:45:04Z

← Older revision		Revision as of 09:45, 24 November 2015
Line 3:		Line 3:
	== Function ==		== Function ==

	'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single ~~immunorecetor tyrosine~~-based ~~activation motif~~ (ITAM). <ref>PMID:24488493</ref>		'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single Immunorecetor Tyrosine-based Activation Motif (ITAM). <ref>PMID:24488493</ref>
	*<scene name='55/551236/Cv/2'>Human CD3 extracellular domain with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]).		*<scene name='55/551236/Cv/2'>Human CD3 extracellular domain with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]).

Michal Harel at 09:40, 24 November 2015

2015-11-24T09:40:01Z

← Older revision		Revision as of 09:40, 24 November 2015
Line 1:		Line 1:
	<StructureSection load='1sy6' size='450' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'>		<StructureSection load='1sy6' size='450' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'>

	'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM). ~~Drugs which bind to CD3 are tested as immunorepressants.~~<ref>PMID:24488493</ref>		== Function ==
	*<scene name='55/551236/Cv/2'>Human CD3 extracellular domain with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]).<ref>PMID:15136729</ref>
			'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM). <ref>PMID:24488493</ref>
			*<scene name='55/551236/Cv/2'>Human CD3 extracellular domain with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]).

			== Relevance ==

			Drugs which bind to CD3 are tested as immunorepressants.
			<ref>PMID:15136729</ref>
	</StructureSection>		</StructureSection>