CD4 - Revision history

Michal Harel at 08:57, 1 May 2019

2019-05-01T08:57:22Z

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 </StructureSection>
 == References ==
 <references/>
 [[Category: Topic Page]]

Michal Harel at 08:56, 1 May 2019

2019-05-01T08:56:17Z

← Older revision		Revision as of 08:56, 1 May 2019
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	HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.<ref>PMID:8493535</ref>		HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.<ref>PMID:8493535</ref>
	*<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref>		*<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref>

			==3D structures of CD4==
			[[CD4 3D structures]]

	</StructureSection>		</StructureSection>
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	*CD4 domains		*CD4 domains

	**[[1cid]] – rCD4 D3 and D4 domains - rat<BR />		**[[3cd4]], [[1cdh]], [[1cdi]], [[1cdj]] – hCD4 D1-D2 domains - human<BR />
	**[[3cd4]], [[1cdh]], [[1cdi]], [[1cdj]] – hCD4 D1 ~~and~~ D2 domains - human<BR />		**[[1cdu]], [[1cdy]] – hCD4 D1-D2 domains (mutant)<BR />
	**[[1cdu]], [[1cdy]] – hCD4 D1 ~~and~~ D2 domains (mutant)<BR />		**[[1wio]], [[1wip]], [[1wiq]] – hCD4 D1-D4 domains <BR />
	**[[1wio]], [[1wip]], [[1wiq]] – hCD4 D1~~, D2, D3 and~~ D4 domains <BR />
	**[[2klu]] – hCD4 transmembrane and tail domains - NMR<BR />		**[[2klu]] – hCD4 transmembrane and tail domains - NMR<BR />
			**[[1cid]] – rCD4 D3-D4 domains - rat<BR />

	*CD4 binary complex		*CD4 binary complex

			**[[3b71]] – hCD4 tail + focal adhesion kinase 1<BR />
			**[[3o2d]], [[4q9i]] – hCD4 D1-D2 domains + antibody <BR />
			**[[5cay]] – hCD4 D1-D2 domains + gp120 <BR />
	**[[1q68]] – hCD4 tail + Lck peptide - NMR<BR />		**[[1q68]] – hCD4 tail + Lck peptide - NMR<BR />
	**[[3b71]] – hCD4 tail + focal adhesion kinase 1<BR />
	**[[3o2d]], [[4q9i]] – hCD4 D1 and D2 domains + antibody <BR />
	**[[5cay]] – hCD4 D1 and D2 domains + gp120 <BR />

	*CD4 higher complexes		*CD4 higher complexes

	**[[1gc1]], [[1g9m]], [[1g9n]], [[1rzj]], [[1rzk]], [[2b4c]], [[2nxy]], [[2nxz]], [[2ny0]], [[2ny1]], [[2ny2]], [[2ny3]], [[2ny4]], [[2ny5]], [[2ny6]], [[3jwd]], [[3jwo]], [[4jm2]], [[4rqs]], [[4r2g]], [[4p9h]], [[4h8w]], [[5a8h]], [[5a7x]] – hCD4 D1 ~~and~~ D2 domains + antibody + gp120<BR />		**[[1gc1]], [[1g9m]], [[1g9n]], [[1rzj]], [[1rzk]], [[2b4c]], [[2nxy]], [[2nxz]], [[2ny0]], [[2ny1]], [[2ny2]], [[2ny3]], [[2ny4]], [[2ny5]], [[2ny6]], [[3jwd]], [[3jwo]], [[4jm2]], [[4rqs]], [[4r2g]], [[4p9h]], [[4h8w]], [[5a8h]], [[5a7x]] – hCD4 D1-D2 domains + antibody + gp120<BR />
	**[[3j70]], [[5u1f]] – hCD4 D1 ~~and~~ D2 domains + antibody + gp120 + gp41<BR />		**[[3j70]], [[5u1f]] – hCD4 D1-D2 domains + antibody + gp120 + gp41<BR />
	**[[5thr]] – hCD4 D1 ~~and~~ D2 domains + antibody + gp120 + gp41 + 8ANC195<BR />		**[[5thr]] – hCD4 D1-D2 domains + antibody + gp120 + gp41 + 8ANC195<BR />
	**[[2qad]], [[3lqa]] – hCD4 D1 ~~and~~ D2 domains + antibody + gp160<BR />		**[[2qad]], [[3lqa]], [[6edu]], [[6cm3]], [[5vn3]] – hCD4 D1-D2 domains + antibody + gp160<BR />
	**[[1jl4]] – hCD4 D1 ~~and~~ D2 domains + class II MHC + ovotransferin peptide<BR />		**[[1jl4]] – hCD4 D1-D2 domains + class II MHC + ovotransferin peptide<BR />
	**[[3s4s]] – hCD4 D1 ~~and~~ D2 domains + class II MHC + haemaglutinin peptide<BR />		**[[3s4s]] – hCD4 D1-D2 domains + class II MHC + haemaglutinin peptide<BR />
	**[[3s5l]] – hCD4 D1 ~~and~~ D2 domains + class II MHC + HA peptide<BR />		**[[3s5l]] – hCD4 D1-D2 domains + class II MHC + HA peptide<BR />
	**[[3t0e]] – hCD4 D1 ~~and~~ D2 domains + class II MHC + TCR<BR />		**[[3t0e]] – hCD4 D1-D2 domains + class II MHC + TCR<BR />
			**[[6meo]], [[6met]] – hCD4 D1-D3 domains + CCR5 + gp120<BR />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category: Topic Page]]		[[Category: Topic Page]]

Michal Harel at 08:42, 1 May 2019

2019-05-01T08:42:28Z

← Older revision		Revision as of 08:42, 1 May 2019
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	== Function ==		== Function ==

	'''CD4''' (or '''Cluster of Differentiation 4''') is a glycoprotein found on the surface of immune cells. CD4 has 4 immunoglobulin (Ig) domains (D1-D4), a transmembrane domain and a cytoplasmic tail domain. D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain. The D1 domain interacts with class II MHC molecules. CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells. The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway.		'''CD4''' (or '''Cluster of Differentiation 4''' or '''T cell surface glycoprotein CD4''') is a glycoprotein found on the surface of immune cells. CD4 has 4 immunoglobulin (Ig) domains (D1-D4), a transmembrane domain and a cytoplasmic tail domain. D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain. The D1 domain interacts with class II MHC molecules. CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells. The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway.

	== Relevance ==		== Relevance ==

Michal Harel at 10:09, 29 March 2017

2017-03-29T10:09:05Z

← Older revision		Revision as of 10:09, 29 March 2017
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	**[[1q68]] – hCD4 tail + Lck peptide - NMR<BR />		**[[1q68]] – hCD4 tail + Lck peptide - NMR<BR />
	**[[3b71]] – hCD4 tail + focal adhesion kinase 1<BR />		**[[3b71]] – hCD4 tail + focal adhesion kinase 1<BR />
	**[[3o2d]] – hCD4 D1 and D2 domains + antibody <BR />		**[[3o2d]], [[4q9i]] – hCD4 D1 and D2 domains + antibody <BR />
			**[[5cay]] – hCD4 D1 and D2 domains + gp120 <BR />

	*CD4 ~~ternary complex~~		*CD4 higher complexes

	**[[1gc1]], [[1g9m]], [[1g9n]], [[1rzj]], [[1rzk]], [[2b4c]], [[2nxy]], [[2nxz]], [[2ny0]], [[2ny1]], [[2ny2]], [[2ny3]], [[2ny4]], [[2ny5]], [[2ny6]], [[3jwd]], [[3jwo]], [[4jm2]] – hCD4 D1 and D2 domains + antibody + gp120<BR />		**[[1gc1]], [[1g9m]], [[1g9n]], [[1rzj]], [[1rzk]], [[2b4c]], [[2nxy]], [[2nxz]], [[2ny0]], [[2ny1]], [[2ny2]], [[2ny3]], [[2ny4]], [[2ny5]], [[2ny6]], [[3jwd]], [[3jwo]], [[4jm2]], [[4rqs]], [[4r2g]], [[4p9h]], [[4h8w]], [[5a8h]], [[5a7x]] – hCD4 D1 and D2 domains + antibody + gp120<BR />
			**[[3j70]], [[5u1f]] – hCD4 D1 and D2 domains + antibody + gp120 + gp41<BR />
			**[[5thr]] – hCD4 D1 and D2 domains + antibody + gp120 + gp41 + 8ANC195<BR />
	**[[2qad]], [[3lqa]] – hCD4 D1 and D2 domains + antibody + gp160<BR />		**[[2qad]], [[3lqa]] – hCD4 D1 and D2 domains + antibody + gp160<BR />
	**[[1jl4]] – hCD4 D1 and D2 domains + class II MHC + ovotransferin peptide<BR />		**[[1jl4]] – hCD4 D1 and D2 domains + class II MHC + ovotransferin peptide<BR />

Alexander Berchansky at 12:26, 29 November 2015

2015-11-29T12:26:50Z

← Older revision		Revision as of 12:26, 29 November 2015
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	<StructureSection load='2nxy' size='~~450~~' side='right' caption='Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (cyan), TRIS and hexane-diol (PDB entry [[2nxy]])' scene='55/551234/Cv/1'>		<StructureSection load='2nxy' size='350' side='right' caption='Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (cyan), TRIS and hexane-diol (PDB entry [[2nxy]])' scene='55/551234/Cv/1'>

Alexander Berchansky at 11:03, 29 November 2015

2015-11-29T11:03:25Z

← Older revision		Revision as of 11:03, 29 November 2015
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	*<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref>		*<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref>

			</StructureSection>
	==3D structures of CD4==		==3D structures of CD4==

Alexander Berchansky at 11:01, 29 November 2015

2015-11-29T11:01:32Z

← Older revision		Revision as of 11:01, 29 November 2015
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	<StructureSection load='2nxy' size='450' side='right' caption='Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (cyan), TRIS and hexane-diol (PDB entry [[2nxy]])' scene='55/551234/Cv/1'>		<StructureSection load='2nxy' size='450' side='right' caption='Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (cyan), TRIS and hexane-diol (PDB entry [[2nxy]])' scene='55/551234/Cv/1'>
	~~</StructureSection>~~
	~~__TOC__~~

	== Function ==		== Function ==

Michal Harel at 08:51, 29 November 2015

2015-11-29T08:51:26Z

← Older revision		Revision as of 08:51, 29 November 2015
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	<StructureSection load='2nxy' size='450' side='right' caption='Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (cyan), TRIS and hexane-diol (PDB entry [[2nxy]])' scene='55/551234/Cv/1'>		<StructureSection load='2nxy' size='450' side='right' caption='Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (cyan), TRIS and hexane-diol (PDB entry [[2nxy]])' scene='55/551234/Cv/1'>
			</StructureSection>
			__TOC__

	== Function ==		== Function ==

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	HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.<ref>PMID:8493535</ref>		HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.<ref>PMID:8493535</ref>
	*<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref>		*<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref>
	~~</StructureSection>~~

	==3D structures of CD4==		==3D structures of CD4==

Michal Harel at 09:51, 24 November 2015

2015-11-24T09:51:07Z

← Older revision		Revision as of 09:51, 24 November 2015
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	<StructureSection load='2nxy' size='450' side='right' caption='Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (cyan), TRIS and hexane-diol (PDB entry [[2nxy]])' scene='55/551234/Cv/1'>		<StructureSection load='2nxy' size='450' side='right' caption='Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (cyan), TRIS and hexane-diol (PDB entry [[2nxy]])' scene='55/551234/Cv/1'>
			== Function ==

	'''CD4''' (or '''Cluster of Differentiation 4''') is a glycoprotein found on the surface of immune cells. CD4 has 4 immunoglobulin (Ig) domains (D1-D4), a transmembrane domain and a cytoplasmic tail domain. D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain. The D1 domain interacts with class II MHC molecules. CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells. The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway. HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.<ref>PMID:8493535</ref>		'''CD4''' (or '''Cluster of Differentiation 4''') is a glycoprotein found on the surface of immune cells. CD4 has 4 immunoglobulin (Ig) domains (D1-D4), a transmembrane domain and a cytoplasmic tail domain. D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain. The D1 domain interacts with class II MHC molecules. CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells. The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway.

			== Relevance ==

			HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.<ref>PMID:8493535</ref>
	*<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref>		*<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref>
	</StructureSection>		</StructureSection>

Michal Harel at 09:49, 24 November 2015

2015-11-24T09:49:53Z

← Older revision		Revision as of 09:49, 24 November 2015
Line 1:		Line 1:
	<StructureSection load='2nxy' size='450' side='right' caption='Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (cyan), TRIS and hexane-diol (PDB entry [[2nxy]])' scene='55/551234/Cv/1'>		<StructureSection load='2nxy' size='450' side='right' caption='Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (cyan), TRIS and hexane-diol (PDB entry [[2nxy]])' scene='55/551234/Cv/1'>

	'''CD4''' (or '''Cluster of Differentiation 4''') is a glycoprotein found on the surface of immune cells. CD4 has 4 immunoglobulin (Ig) domains, a transmembrane domain and a cytoplasmic tail domain. D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain. The D1 domain interacts with class II MHC molecules. CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells. The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway. HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.<ref>PMID:8493535</ref>		'''CD4''' (or '''Cluster of Differentiation 4''') is a glycoprotein found on the surface of immune cells. CD4 has 4 immunoglobulin (Ig) domains (D1-D4), a transmembrane domain and a cytoplasmic tail domain. D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain. The D1 domain interacts with class II MHC molecules. CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells. The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway. HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.<ref>PMID:8493535</ref>
	*<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref>		*<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref>
	</StructureSection>		</StructureSection>