CD8 - Revision history

Michal Harel at 09:03, 1 May 2019

2019-05-01T09:03:44Z

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 </StructureSection>
 == References ==
 <references/>
 [[Category: Topic Page]]

Michal Harel at 09:02, 1 May 2019

2019-05-01T09:02:41Z

← Older revision		Revision as of 09:02, 1 May 2019
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	'''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.<ref>PMID:9916707</ref>		'''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.<ref>PMID:9916707</ref>
	*<scene name='55/551462/Cv/2'>CD8α, CD8β and antibody</scene> ([[3b9k]]).<ref>PMID:18929574</ref>		*<scene name='55/551462/Cv/2'>CD8α, CD8β and antibody</scene> ([[3b9k]]).<ref>PMID:18929574</ref>

			== 3D Structures of CD8 ==
			[[CD8 3D structures]]

	</StructureSection>		</StructureSection>
	== 3D Structures of CD8 ==		== 3D Structures of CD8 ==
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	**[[2q3a]] – CD8 extracellular domain – rhesus monkey <BR />		**[[2q3a]] – CD8 extracellular domain – rhesus monkey <BR />
	**[[5edx]] – CD8 extracellular domain – pig <BR />		**[[5edx]] – CD8 extracellular domain – pig <BR />
			**[[5z11]] – CD8 extracellular domain – carp <BR />

	*CD8α complex		*CD8α complex

Michal Harel at 10:18, 29 March 2017

2017-03-29T10:18:37Z

← Older revision		Revision as of 10:18, 29 March 2017
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	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|

	*~~CD8~~		*CD8α

	**[[1cd8]] – hCD8 extracellular domain – human <BR />		**[[1cd8]] – hCD8 extracellular domain – human <BR />
			**[[2hp4]] - hCD8 extracellular domain (mutant) <BR />
			**[[5eb9]] – CD8 extracellular domain – chicken <BR />
			**[[5ebg]] – CD8 extracellular domain – bovine <BR />
			**[[2q3a]] – CD8 extracellular domain – rhesus monkey <BR />
			**[[5edx]] – CD8 extracellular domain – pig <BR />

	*CD8α		*CD8α complex

	**[[2hp4]] - hCD8 extracellular domain (mutant) <BR />
	**[[1akj]] - hCD8 extracellular domain + class I MHC + β-2-microglobulin + HIV reverse transcriptase peptide <BR />		**[[1akj]] - hCD8 extracellular domain + class I MHC + β-2-microglobulin + HIV reverse transcriptase peptide <BR />
	**[[3qzw]] - hCD8 extracellular domain + class I MHC + β-2-microglobulin + NEF peptide <BR />		**[[3qzw]] - hCD8 extracellular domain + class I MHC + β-2-microglobulin + NEF peptide <BR />
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	**[[1q69]] - hCD8 residues 209-227 + Lck peptide - NMR<BR />		**[[1q69]] - hCD8 residues 209-227 + Lck peptide - NMR<BR />
	**[[2arj]] - rCD8 extracellular domain + antibody - rat <BR />		**[[2arj]] - rCD8 extracellular domain + antibody - rat <BR />
	**[[2q3a]] – CD8 extracellular domain – rhesus monkey <BR />

	*CD8α and CD8β		*CD8α and CD8β

Alexander Berchansky at 12:27, 29 November 2015

2015-11-29T12:27:34Z

← Older revision		Revision as of 12:27, 29 November 2015
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	<StructureSection load='3b9k' size='~~450~~' side='right' caption='Structure of CD8α (magenta) and CD8β (green) complex with antibody heavy chain (cyan) and light chain (salmon) (PDB entry [[3b9k]])' scene='55/551462/Cv/1'>		<StructureSection load='3b9k' size='350' side='right' caption='Structure of CD8α (magenta) and CD8β (green) complex with antibody heavy chain (cyan) and light chain (salmon) (PDB entry [[3b9k]])' scene='55/551462/Cv/1'>

Alexander Berchansky at 11:02, 29 November 2015

2015-11-29T11:02:58Z

← Older revision		Revision as of 11:02, 29 November 2015
Line 6:		Line 6:
	'''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.<ref>PMID:9916707</ref>		'''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.<ref>PMID:9916707</ref>
	*<scene name='55/551462/Cv/2'>CD8α, CD8β and antibody</scene> ([[3b9k]]).<ref>PMID:18929574</ref>		*<scene name='55/551462/Cv/2'>CD8α, CD8β and antibody</scene> ([[3b9k]]).<ref>PMID:18929574</ref>
			</StructureSection>
	== 3D Structures of CD8 ==		== 3D Structures of CD8 ==

Alexander Berchansky at 11:02, 29 November 2015

2015-11-29T11:02:28Z

← Older revision		Revision as of 11:02, 29 November 2015
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	<StructureSection load='3b9k' size='450' side='right' caption='Structure of CD8α (magenta) and CD8β (green) complex with antibody heavy chain (cyan) and light chain (salmon) (PDB entry [[3b9k]])' scene='55/551462/Cv/1'>		<StructureSection load='3b9k' size='450' side='right' caption='Structure of CD8α (magenta) and CD8β (green) complex with antibody heavy chain (cyan) and light chain (salmon) (PDB entry [[3b9k]])' scene='55/551462/Cv/1'>
	~~</StructureSection>~~
	~~__TOC__~~

	== Function ==		== Function ==

Michal Harel at 08:54, 29 November 2015

2015-11-29T08:54:38Z

← Older revision		Revision as of 08:54, 29 November 2015
Line 1:		Line 1:
	<StructureSection load='3b9k' size='450' side='right' caption='Structure of CD8α (magenta) and CD8β (green) complex with antibody heavy chain (cyan) and light chain (salmon) (PDB entry [[3b9k]])' scene='55/551462/Cv/1'>		<StructureSection load='3b9k' size='450' side='right' caption='Structure of CD8α (magenta) and CD8β (green) complex with antibody heavy chain (cyan) and light chain (salmon) (PDB entry [[3b9k]])' scene='55/551462/Cv/1'>
			</StructureSection>
			__TOC__

			== Function ==

	'''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.<ref>PMID:9916707</ref>		'''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.<ref>PMID:9916707</ref>
	*<scene name='55/551462/Cv/2'>CD8α, CD8β and antibody</scene> ([[3b9k]]).<ref>PMID:18929574</ref>		*<scene name='55/551462/Cv/2'>CD8α, CD8β and antibody</scene> ([[3b9k]]).<ref>PMID:18929574</ref>
	~~</StructureSection>~~

	== 3D Structures of CD8 ==		== 3D Structures of CD8 ==

Alexander Berchansky at 12:26, 24 November 2015

2015-11-24T12:26:09Z

← Older revision		Revision as of 12:26, 24 November 2015
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	<StructureSection load='3b9k' size='450' side='right' caption='Structure of CD8α (magenta) and CD8β (green) complex with antibody heavy chain (cyan) and light chain (salmon) (PDB entry [[3b9k]])' scene='55/551462/Cv/1'>		<StructureSection load='3b9k' size='450' side='right' caption='Structure of CD8α (magenta) and CD8β (green) complex with antibody heavy chain (cyan) and light chain (salmon) (PDB entry [[3b9k]])' scene='55/551462/Cv/1'>

	'''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.		'''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.<ref>PMID:9916707</ref>
	*<scene name='55/551462/Cv/2'>CD8α, CD8β and antibody</scene> ([[3b9k]]).<ref>PMID:18929574</ref>		*<scene name='55/551462/Cv/2'>CD8α, CD8β and antibody</scene> ([[3b9k]]).<ref>PMID:18929574</ref>
	</StructureSection>		</StructureSection>

Alexander Berchansky at 12:25, 24 November 2015

2015-11-24T12:25:34Z

← Older revision		Revision as of 12:25, 24 November 2015
Line 2:		Line 2:

	'''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.		'''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.
	*<scene name='55/551462/Cv/2'>CD8α, CD8β and antibody</scene> ([[3b9k]]).		*<scene name='55/551462/Cv/2'>CD8α, CD8β and antibody</scene> ([[3b9k]]).<ref>PMID:18929574</ref>
	</StructureSection>		</StructureSection>

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	**[[3b9k]] - mCD8 + antibody <BR />		**[[3b9k]] - mCD8 + antibody <BR />
	}}		}}
			== References ==
			<references/>
	[[Category: Topic Page]]		[[Category: Topic Page]]

Alexander Berchansky at 12:24, 24 November 2015

2015-11-24T12:24:33Z

← Older revision		Revision as of 12:24, 24 November 2015
Line 1:		Line 1:
	<StructureSection load='3b9k' size='~~350~~' side='right' caption='Structure of CD8α (magenta) and CD8β (green) complex with antibody heavy chain (cyan) and light chain (salmon) (PDB entry [[3b9k]])' scene='55/551462/Cv/1'>		<StructureSection load='3b9k' size='450' side='right' caption='Structure of CD8α (magenta) and CD8β (green) complex with antibody heavy chain (cyan) and light chain (salmon) (PDB entry [[3b9k]])' scene='55/551462/Cv/1'>

	'''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.		'''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.
			*<scene name='55/551462/Cv/2'>CD8α, CD8β and antibody</scene> ([[3b9k]]).
	</StructureSection>		</StructureSection>