Complement C3 - Revision history

Michal Harel at 08:57, 5 June 2024

2024-06-05T08:57:09Z

← Older revision		Revision as of 08:57, 5 June 2024
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	*'''C3a''' is a mediator of local inflammatory processes.		*'''C3a''' is a mediator of local inflammatory processes.
	*'''C3b''' binds covalently to cell surface carbohydrates or immune aggregates.		*'''C3b''' binds covalently to cell surface carbohydrates or immune aggregates.
	*'''C3d''' is a fragment generated by C3b(residues 996-1287) which binds to antigens enhancing their uptake by B cells.
	*'''C3c''' is another C3b cleavage product residues: 23-664, 749-954, 1321-1663.<ref>PMID:11414361</ref>		*'''C3c''' is another C3b cleavage product residues: 23-664, 749-954, 1321-1663.<ref>PMID:11414361</ref>
			*'''C3d''' is a fragment generated by C3b(residues 996-1287) which binds to antigens enhancing their uptake by B cells<ref>PMID:17337780</ref>.

	<scene name='59/594590/Cv/2'>C3b α and β chains with protein CRIG and Ca+2 ion</scene>.		<scene name='59/594590/Cv/2'>C3b α and β chains with protein CRIG and Ca+2 ion</scene>.

Michal Harel at 08:54, 5 June 2024

2024-06-05T08:54:21Z

← Older revision		Revision as of 08:54, 5 June 2024
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	*'''C3a''' is a mediator of local inflammatory processes.		*'''C3a''' is a mediator of local inflammatory processes.
	*'''C3b''' binds covalently to cell surface carbohydrates or immune aggregates.		*'''C3b''' binds covalently to cell surface carbohydrates or immune aggregates.
	*~~Breakdown of C3b generates the fragment~~ '''C3d''' (residues 996-1287) which binds to antigens enhancing their uptake by B cells.		*'''C3d''' is a fragment generated by C3b(residues 996-1287) which binds to antigens enhancing their uptake by B cells.
	*'''C3c''' is another C3b cleavage product residues: 23-664, 749-954, 1321-1663.<ref>PMID:11414361</ref>		*'''C3c''' is another C3b cleavage product residues: 23-664, 749-954, 1321-1663.<ref>PMID:11414361</ref>

Michal Harel at 08:52, 5 June 2024

2024-06-05T08:52:48Z

← Older revision		Revision as of 08:52, 5 June 2024
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	== Function ==		== Function ==

	'''Complement C3''' (CC3) activates the complement system which is part of the immune response. CC3 is proteolytically cleaved by C3 convertase to C3a (residues 672-748) and C3b (residues 23-667, 749-1663). C3a is a mediator of local inflammatory processes. C3b binds covalently to cell surface carbohydrates or immune aggregates. Breakdown of C3b generates the fragment C3d (residues 996-1287) which binds to antigens enhancing their uptake by B cells. C3c is another C3b cleavage product residues: 23-664, 749-954, 1321-1663.<ref>PMID:11414361</ref>		'''Complement C3''' (CC3) activates the complement system which is part of the immune response. '''CC3''' is proteolytically cleaved by C3 convertase to '''C3a''' (residues 672-748) and '''C3b''' (residues 23-667, 749-1663).
			*'''C3a''' is a mediator of local inflammatory processes.
			*'''C3b''' binds covalently to cell surface carbohydrates or immune aggregates.
			*Breakdown of C3b generates the fragment '''C3d''' (residues 996-1287) which binds to antigens enhancing their uptake by B cells.
			*'''C3c''' is another C3b cleavage product residues: 23-664, 749-954, 1321-1663.<ref>PMID:11414361</ref>

	<scene name='59/594590/Cv/2'>C3b α and β chains with protein CRIG and Ca+2 ion</scene>.		<scene name='59/594590/Cv/2'>C3b α and β chains with protein CRIG and Ca+2 ion</scene>.

Michal Harel at 10:15, 14 May 2019

2019-05-14T10:15:34Z

← Older revision		Revision as of 10:15, 14 May 2019
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	</StructureSection>		</StructureSection>

	~~==3D structures of complement C3==~~

	~~Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}~~
	~~{{#tree:id=OrganizedByTopic\|openlevels=0\|~~

	*Complement C3

	**[[2a73]] – hCC3 – human <br />
	**[[1ghq]] – hCC3 residues 996-1300 + Epstein-Barr virus receptor <br />
	**[[4zh1]] – hCC3 + complement factor H <br />
	**[[2b39]] – bCC3 – bovine <br />

	*Complement C3a (anaphylatoxin)

	**[[4hw5]], [[4hwj]], [[4i6o]] – hCC3 <br />

	*Complement C3b

	**[[2i07]], [[5fo7]] – hCC3 β+α’ chains<br />
	**[[5fob]] – hCC3 β+α’ chains + inhibitor<br />
	**[[5fo9]] – hCC3 β+α’ chains + protein<br />
	**[[5foa]], [[5f08]], [[2icf]], [[2wii]] – hCC3 α+β chains + protein <br />
	**[[3g6j]], [[6ehg]] – hCC3 α+β chains + antibody<br />
	**[[5o35]] – hCC3 α chain + complement factor H<br />
	**[[5o32]] – hCC3 α chain + complement factor I<br />
	**[[2xwb]] – hCC3 α+β chains + complement factor B + complement factor D<br />
	**[[2xwj]] – hCC3 α+β chains (mutant) + complement factor B<br />
	**[[5nbq]] – hCC3 α chain + complement factor B <br />
	**[[5fo8]] – hCC3 α chain + membrane cofactor protein<br />
	**[[5m6w]] – hCC3 α+β chains + complement factor H + complement inhibitor<br />
	**[[3l5n]], [[3ohx]] – hCC3 α+β chains + protein inhibitor<br />
	**[[2win]] – hCC3 α+β chains + complement factor B BB fragment + protein inhibitor<br />

	*Complement C3c

	**[[2a74]] – hCC3 <br />
	**[[2qki]] – hCC3 + compstatin <br />
	**[[3l3o]], [[3nms]] – hCC3 + staphylococcal complement inhibitor<br />
	**[[2ice]] – hCC3 α+β chains + protein CRIG<br />
	**[[3t4a]] – hCC3 α+β chains + fibrinogen-binding protein <br />

	*Complement C3d

	**[[5fcr]] – CC3 - mouse <br />
	**[[1c3d]] – hCC3 (mutant) <br />
	**[[1w2s]], [[3oed]] – hCC3 1-2 sushi domains + complement receptor type 2 precursor<br />
	**[[2gox]], [[3d5r]], [[3d5s]] – hCC3 α chain fragment + fibrinogen-binding protein <br />
	**[[2noj]] – hCC3 α chain fragment (mutant) + EFB homologous protein <br />
	**[[2wy7]], [[2wy8]] – hCC3 α chain fragment (mutant) + IGG-binding protein <br />
	**[[3oxu]] – hCC3 α chain fragment (mutant) + HF protein <br />
	**[[4m76]] – hCC3 α chain fragment (mutant) + integrin α-M <br />
	**[[2xqw]] – hCC3 + complement factor H 19-20 sushi domains<br />
	**[[3rj3]] – hCC3 α chain fragment + complement factor H-related protein<br />
	**[[5mt0]], [[5mt4]], [[5tca]], [[5tcc]], [[5fbe]], [[5fbi]], [[5fck]] – hCC3 + inhibitor<br />
	**[[1qqf]] – rCC3 G fragment - rat <br />
	**[[1qsj]] – rCC3 G fragment (mutant) <br />
	}}





	== References ==		== References ==

Michal Harel at 10:14, 14 May 2019

2019-05-14T10:14:21Z

← Older revision		Revision as of 10:14, 14 May 2019
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	Low levels of CC3 in the blood are associated with some kidney diseases.		Low levels of CC3 in the blood are associated with some kidney diseases.

			==3D structures of complement C3==
			[[Complement C3 3D structures]]

	</StructureSection>		</StructureSection>

Alexander Berchansky at 06:40, 18 February 2019

2019-02-18T06:40:53Z

← Older revision		Revision as of 06:40, 18 February 2019
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	<scene name='59/594590/Cv/2'>C3b α and β chains with protein CRIG and Ca+2 ion</scene>.		<scene name='59/594590/Cv/2'>C3b α and β chains with protein CRIG and Ca+2 ion</scene>.

	<scene name='59/594590/Cv/3'>Ca+2 ion coordination site</scene> (PDB code [[2icf]]).<ref>PMID:17051150</ref>		<scene name='59/594590/Cv/4'>Ca+2 ion coordination site</scene> (PDB code [[2icf]]).<ref>PMID:17051150</ref>

	== Disease ==		== Disease ==

Alexander Berchansky at 12:53, 18 July 2018

2018-07-18T12:53:16Z

← Older revision		Revision as of 12:53, 18 July 2018
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	**[[2xqw]] – hCC3 + complement factor H 19-20 sushi domains<br />		**[[2xqw]] – hCC3 + complement factor H 19-20 sushi domains<br />
	**[[3rj3]] – hCC3 α chain fragment + complement factor H-related protein<br />		**[[3rj3]] – hCC3 α chain fragment + complement factor H-related protein<br />
	**[[5mt0]], [[5mt4]], [[5tca]], [[5tcc]], [[5fbe]], [[5fbi]], [[5fck]]		**[[5mt0]], [[5mt4]], [[5tca]], [[5tcc]], [[5fbe]], [[5fbi]], [[5fck]] – hCC3 + inhibitor<br />
	– hCC3 + inhibitor<br />
	**[[1qqf]] – rCC3 G fragment - rat <br />		**[[1qqf]] – rCC3 G fragment - rat <br />
	**[[1qsj]] – rCC3 G fragment (mutant) <br />		**[[1qsj]] – rCC3 G fragment (mutant) <br />

Michal Harel at 09:30, 12 April 2018

2018-04-12T09:30:03Z

← Older revision		Revision as of 09:30, 12 April 2018
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	**[[5fo9]] – hCC3 β+α’ chains + protein<br />		**[[5fo9]] – hCC3 β+α’ chains + protein<br />
	**[[5foa]], [[5f08]], [[2icf]], [[2wii]] – hCC3 α+β chains + protein <br />		**[[5foa]], [[5f08]], [[2icf]], [[2wii]] – hCC3 α+β chains + protein <br />
	**[[3g6j]] – hCC3 α+β chains + antibody<br />		**[[3g6j]], [[6ehg]] – hCC3 α+β chains + antibody<br />
			**[[5o35]] – hCC3 α chain + complement factor H<br />
			**[[5o32]] – hCC3 α chain + complement factor I<br />
	**[[2xwb]] – hCC3 α+β chains + complement factor B + complement factor D<br />		**[[2xwb]] – hCC3 α+β chains + complement factor B + complement factor D<br />
	**[[2xwj]] – hCC3 α+β chains (mutant) + complement factor B<br />		**[[2xwj]] – hCC3 α+β chains (mutant) + complement factor B<br />
			**[[5nbq]] – hCC3 α chain + complement factor B <br />
			**[[5fo8]] – hCC3 α chain + membrane cofactor protein<br />
			**[[5m6w]] – hCC3 α+β chains + complement factor H + complement inhibitor<br />
	**[[3l5n]], [[3ohx]] – hCC3 α+β chains + protein inhibitor<br />		**[[3l5n]], [[3ohx]] – hCC3 α+β chains + protein inhibitor<br />
	**[[2win]] – hCC3 α+β chains + complement factor B BB fragment + protein inhibitor<br />		**[[2win]] – hCC3 α+β chains + complement factor B BB fragment + protein inhibitor<br />

Michal Harel at 08:08, 4 April 2017

2017-04-04T08:08:01Z

← Older revision		Revision as of 08:08, 4 April 2017
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	**[[2a73]] – hCC3 – human <br />		**[[2a73]] – hCC3 – human <br />
	**[[1ghq]] – hCC3 residues 996-1300 + Epstein-Barr virus receptor <br />		**[[1ghq]] – hCC3 residues 996-1300 + Epstein-Barr virus receptor <br />
			**[[4zh1]] – hCC3 + complement factor H <br />
	**[[2b39]] – bCC3 – bovine <br />		**[[2b39]] – bCC3 – bovine <br />

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	*Complement C3b		*Complement C3b

	**[[2i07]] – hCC3 β+α’ chains<br />		**[[2i07]], [[5fo7]] – hCC3 β+α’ chains<br />
	**[[2icf]] – hCC3 α+β chains + protein ~~CRIG~~<br />		**[[5fob]] – hCC3 β+α’ chains + inhibitor<br />
			**[[5fo9]] – hCC3 β+α’ chains + protein<br />
			**[[5foa]], [[5f08]], [[2icf]], [[2wii]] – hCC3 α+β chains + protein <br />
	**[[3g6j]] – hCC3 α+β chains + antibody<br />		**[[3g6j]] – hCC3 α+β chains + antibody<br />
	**[[2xwb]] – hCC3 α+β chains + complement factor B + complement factor D<br />		**[[2xwb]] – hCC3 α+β chains + complement factor B + complement factor D<br />
	**[[2xwj]] – hCC3 α+β chains (mutant) + complement factor B<br />		**[[2xwj]] – hCC3 α+β chains (mutant) + complement factor B<br />
	**[[2wii]] – hCC3 α+β chains + complement factor H 1-4 sushi domains<br />		**[[3l5n]], [[3ohx]] – hCC3 α+β chains + protein inhibitor<br />
	**[[3l5n]], [[3ohx]] – hCC3 α+β chains + ~~staphylococcal complement~~ inhibitor<br />		**[[2win]] – hCC3 α+β chains + complement factor B BB fragment + protein inhibitor<br />
	**[[2win]] – hCC3 α+β chains + complement factor B BB fragment + ~~staphylococcal complement~~ inhibitor<br />

	*Complement C3c		*Complement C3c
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	*Complement C3d		*Complement C3d

			**[[5fcr]] – CC3 - mouse <br />
	**[[1c3d]] – hCC3 (mutant) <br />		**[[1c3d]] – hCC3 (mutant) <br />
	**[[1w2s]], [[3oed]] – hCC3 1-2 sushi domains + complement receptor type 2 precursor<br />		**[[1w2s]], [[3oed]] – hCC3 1-2 sushi domains + complement receptor type 2 precursor<br />
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	**[[2xqw]] – hCC3 + complement factor H 19-20 sushi domains<br />		**[[2xqw]] – hCC3 + complement factor H 19-20 sushi domains<br />
	**[[3rj3]] – hCC3 α chain fragment + complement factor H-related protein<br />		**[[3rj3]] – hCC3 α chain fragment + complement factor H-related protein<br />
			**[[5mt0]], [[5mt4]], [[5tca]], [[5tcc]], [[5fbe]], [[5fbi]], [[5fck]]
			– hCC3 + inhibitor<br />
	**[[1qqf]] – rCC3 G fragment - rat <br />		**[[1qqf]] – rCC3 G fragment - rat <br />
	**[[1qsj]] – rCC3 G fragment (mutant) <br />		**[[1qsj]] – rCC3 G fragment (mutant) <br />

Michal Harel at 09:16, 16 November 2016

2016-11-16T09:16:14Z

← Older revision		Revision as of 09:16, 16 November 2016
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	*Complement C3b		*Complement C3b

	**~~[[2hr0]],~~ [[2i07]] – hCC3 β+α’ chains<br />		**[[2i07]] – hCC3 β+α’ chains<br />
	**[[2icf]] – hCC3 α+β chains + protein CRIG<br />		**[[2icf]] – hCC3 α+β chains + protein CRIG<br />
	**[[3g6j]] – hCC3 α+β chains + antibody<br />		**[[3g6j]] – hCC3 α+β chains + antibody<br />