Complement C5 - Revision history

Joel L. Sussman at 15:51, 9 August 2026

2026-08-09T15:51:52Z

← Older revision		Revision as of 15:51, 9 August 2026
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	<StructureSection load='' size='350' side='right' caption='Human complement C5 complex (green) with cobra venom factor (magenta) (PDB code [[~~3pvm~~]])' scene='70/705685/Cv/6'>		<StructureSection load='' size='350' side='right' caption='Human complement C5 complex (green) with cobra venom factor (magenta) (PDB code [[9tdl]])' scene='70/705685/Cv/6'>
	__TOC__		__TOC__
	== Function ==		== Function ==

2019-05-15T06:38:45Z

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 </StructureSection>
 == References ==
 <references/>
 [[Category:Topic Page]]

2019-05-15T06:37:46Z

← Older revision		Revision as of 06:37, 15 May 2019
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	Mutations in CC5 cause a deficiency leading to severe recurrent infections and are linked to liver fibrosis, Leiner's disease and rheumatoid arthritis.		Mutations in CC5 cause a deficiency leading to severe recurrent infections and are linked to liver fibrosis, Leiner's disease and rheumatoid arthritis.

			== 3D Structures of complement C5 ==
			[[Complement C5 3D structures]]

	</StructureSection>		</StructureSection>

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	**[[5hcd]] – hCC5 + complement inhibitor + RACI2<BR />		**[[5hcd]] – hCC5 + complement inhibitor + RACI2<BR />
	**[[5hce]] – hCC5 + complement inhibitor + RACI1<BR />		**[[5hce]] – hCC5 + complement inhibitor + RACI1<BR />
			**[[6h04]] – hCC5 + hCC9 + hCC8 a+b+g chains + hCC7 – Cryo EM<BR />

	*C345C		*C345C

2019-02-18T06:45:37Z

← Older revision		Revision as of 06:45, 18 February 2019
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	<StructureSection load='' size='350' side='right' caption='Human complement C5 complex (green) with cobra venom factor (magenta) (PDB code [[3pvm]])' scene='70/705685/Cv/1'>		<StructureSection load='' size='350' side='right' caption='Human complement C5 complex (green) with cobra venom factor (magenta) (PDB code [[3pvm]])' scene='70/705685/Cv/6'>
	__TOC__		__TOC__
	== Function ==		== Function ==

2019-02-18T06:43:58Z

← Older revision		Revision as of 06:43, 18 February 2019
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	== Function ==		== Function ==

	'''Complement C5''' (CC5) is the fifth component of the complement system. The complement system is part of the innate immune system. CC5 is composed of α chain (C5a) and β chain (C5b). Proteoplytic degradation of CC5 produces <scene name='70/705685/Cv/2'>anaphylatoxin</scene> which is a mediator of local inflammatory process. The C terminal domain of CC5 (residues 1530-1676) is homologous to a domain in netrins and is named <scene name='70/705685/Cv/3'>C345C</scene>. Activation of CC5 by C5 convertase initiates the assembly of the C5 to C9 components into the membrane attack complex. <ref>PMID:18536718</ref>		'''Complement C5''' (CC5) is the fifth component of the complement system. The complement system is part of the innate immune system. CC5 is composed of α chain (C5a) and β chain (C5b). Proteoplytic degradation of CC5 produces <scene name='70/705685/Cv/4'>anaphylatoxin</scene> which is a mediator of local inflammatory process. The C terminal domain of CC5 (residues 1530-1676) is homologous to a domain in netrins and is named <scene name='70/705685/Cv/5'>C345C</scene>. Activation of CC5 by C5 convertase initiates the assembly of the C5 to C9 components into the membrane attack complex. <ref>PMID:18536718</ref>

	== Disease ==		== Disease ==

2018-04-12T09:41:53Z

← Older revision		Revision as of 09:41, 12 April 2018
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	**[[4a5w]], [[4e0s]] – hCC5 + CC6<BR />		**[[4a5w]], [[4e0s]] – hCC5 + CC6<BR />
	**[[5i5k]], [[4uu9]] – hCC5 + antibody<BR />		**[[5i5k]], [[4uu9]] – hCC5 + antibody<BR />
			**[[5b71]] – hCC5 β chain + antibody<BR />
	**[[5hcc]] – hCC5 + complement inhibitor + RACI3<BR />		**[[5hcc]] – hCC5 + complement inhibitor + RACI3<BR />
	**[[5hcd]] – hCC5 + complement inhibitor + RACI2<BR />		**[[5hcd]] – hCC5 + complement inhibitor + RACI2<BR />
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	**[[1kjs]], [[3hqa]], [[3hqb]] – hCC5 <BR />		**[[1kjs]], [[3hqa]], [[3hqb]] – hCC5 <BR />
	**[[4p39]] – hCC5 (mutant)<BR />		**[[4p39]] – hCC5 (mutant)<BR />
			**[[5b4p]] – hCC5 + antibody<BR />
	**[[4p3a]], [[4p3b]] – mCC5 - mouse <BR />		**[[4p3a]], [[4p3b]] – mCC5 - mouse <BR />
	**[[4wb3]], [[4wb2]] – mCC5 + DNA/RNA <BR />		**[[4wb3]], [[4wb2]] – mCC5 + DNA/RNA <BR />

2017-10-20T09:33:57Z

← Older revision		Revision as of 09:33, 20 October 2017
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	<StructureSection load='~~3pvm~~' size='350' side='right' caption='Human complement C5 complex (green) with cobra venom factor (magenta) (PDB code [[3pvm]])' scene='70/705685/Cv/1'>		<StructureSection load='' size='350' side='right' caption='Human complement C5 complex (green) with cobra venom factor (magenta) (PDB code [[3pvm]])' scene='70/705685/Cv/1'>
	__TOC__		__TOC__
	== Function ==		== Function ==

2017-10-19T14:42:24Z

2017-04-04T08:58:05Z

← Older revision		Revision as of 08:58, 4 April 2017
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	**[[3prx]] – hCC5 + cobra venom factor + SSL7<BR />		**[[3prx]] – hCC5 + cobra venom factor + SSL7<BR />
	**[[4a5w]], [[4e0s]] – hCC5 + CC6<BR />		**[[4a5w]], [[4e0s]] – hCC5 + CC6<BR />
			**[[5i5k]], [[4uu9]] – hCC5 + antibody<BR />
			**[[5hcc]] – hCC5 + complement inhibitor + RACI3<BR />
			**[[5hcd]] – hCC5 + complement inhibitor + RACI2<BR />
			**[[5hce]] – hCC5 + complement inhibitor + RACI1<BR />

	*C345C		*C345C
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	**[[1kjs]], [[3hqa]], [[3hqb]] – hCC5 <BR />		**[[1kjs]], [[3hqa]], [[3hqb]] – hCC5 <BR />
			**[[4p39]] – hCC5 (mutant)<BR />
	**[[4p3a]], [[4p3b]] – mCC5 - mouse <BR />		**[[4p3a]], [[4p3b]] – mCC5 - mouse <BR />
	**[[4wb3]], [[4wb2]] – mCC5 + DNA/RNA <BR />		**[[4wb3]], [[4wb2]] – mCC5 + DNA/RNA <BR />

2015-12-20T12:08:28Z

← Older revision		Revision as of 12:08, 20 December 2015
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	== Function ==		== Function ==

	'''Complement C5''' (CC5) is the fifth component of the complement system. The complement system is part of the innate immune system. CC5 is composed of α chain (C5a) and β chain (C5b). Proteoplytic degradation of CC5 produces <scene name='70/705685/Cv/3'>anaphylatoxin</scene> which is a mediator of local inflammatory process. The C terminal domain of CC5 (residues 1530-1676) is homologous to a domain in netrins and is named <scene name='70/705685/Cv/3'>C345C</scene>. Activation of CC5 by C5 convertase initiates the assembly of the C5 to C9 components into the membrane attack complex. <ref>PMID:18536718</ref>		'''Complement C5''' (CC5) is the fifth component of the complement system. The complement system is part of the innate immune system. CC5 is composed of α chain (C5a) and β chain (C5b). Proteoplytic degradation of CC5 produces <scene name='70/705685/Cv/2'>anaphylatoxin</scene> which is a mediator of local inflammatory process. The C terminal domain of CC5 (residues 1530-1676) is homologous to a domain in netrins and is named <scene name='70/705685/Cv/3'>C345C</scene>. Activation of CC5 by C5 convertase initiates the assembly of the C5 to C9 components into the membrane attack complex. <ref>PMID:18536718</ref>

	== Disease ==		== Disease ==