Complexin - Revision history

Michal Harel at 07:59, 7 July 2020

2020-07-07T07:59:31Z

← Older revision		Revision as of 07:59, 7 July 2020
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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

			[[3rk3]], [[3rl0]] - CPLX + Vamp2 + Syntaxin 1A + Snap25 – human<br />
	[[1kil]] – rCPLX + Vamp2 + Syntaxin 1A + Snap25 – rat<br />		[[1kil]] – rCPLX + Vamp2 + Syntaxin 1A + Snap25 – rat<br />
	~~[[3rk3]], [[3rl0]] - CPLX + Vamp2 + Syntaxin 1A + Snap25 – human<br />~~		[[5w5c]], [[5w5d]] - rCPLX + Vamp2 + Syntaxin 1A + Snap25 + synaptotagmin <br />
	[[5w5c]], [[5w5d]] - ~~CPLX~~ + Vamp2 + Syntaxin 1A + Snap25 + synaptotagmin <br />
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 10:04, 15 April 2018

2018-04-15T10:04:50Z

← Older revision		Revision as of 10:04, 15 April 2018
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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

	[[1kil]] – rCPLX + Vamp2 + Syntaxin 1A + Snap25 – rat		[[1kil]] – rCPLX + Vamp2 + Syntaxin 1A + Snap25 – rat<br />
			[[3rk3]], [[3rl0]] - CPLX + Vamp2 + Syntaxin 1A + Snap25 – human<br />
	[[3rk3]], [[3rl0]] - CPLX + Vamp2 + Syntaxin 1A + Snap25 – human

	[[5w5c]], [[5w5d]] - CPLX + Vamp2 + Syntaxin 1A + Snap25 + synaptotagmin <br />		[[5w5c]], [[5w5d]] - CPLX + Vamp2 + Syntaxin 1A + Snap25 + synaptotagmin <br />
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 10:04, 15 April 2018

2018-04-15T10:04:19Z

← Older revision		Revision as of 10:04, 15 April 2018
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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

	[[1kil]] – ~~CPLX~~ + ~~SNARE~~ – rat		[[1kil]] – rCPLX + Vamp2 + Syntaxin 1A + Snap25 – rat

	[[3rk3]], [[3rl0]] - CPLX + ~~SNARE~~ – human		[[3rk3]], [[3rl0]] - CPLX + Vamp2 + Syntaxin 1A + Snap25 – human

			[[5w5c]], [[5w5d]] - CPLX + Vamp2 + Syntaxin 1A + Snap25 + synaptotagmin <br />
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Alexander Berchansky at 12:36, 20 December 2015

2015-12-20T12:36:05Z

← Older revision		Revision as of 12:36, 20 December 2015
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	== Structural highlights ==		== Structural highlights ==

	<scene name='46/466533/Cv/2'>CPLX binds to v-SNARE protein VAMP2 and to t-SNARE proteins SNAP25 and syntaxin</scene>.		<scene name='46/466533/Cv/2'>CPLX binds to v-SNARE protein VAMP2 and to t-SNARE proteins SNAP25 and syntaxin</scene> (PDB entry [[3rk3]]).<ref>PMID:21785414</ref>

	</StructureSection>		</StructureSection>

Alexander Berchansky at 12:35, 20 December 2015

2015-12-20T12:35:15Z

← Older revision		Revision as of 12:35, 20 December 2015
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	== Structural highlights ==		== Structural highlights ==

	CPLX binds to v-SNARE protein VAMP2 and to t-SNARE proteins SNAP25 and syntaxin.		<scene name='46/466533/Cv/2'>CPLX binds to v-SNARE protein VAMP2 and to t-SNARE proteins SNAP25 and syntaxin</scene>.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 12:31, 20 December 2015

2015-12-20T12:31:08Z

← Older revision		Revision as of 12:31, 20 December 2015
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			<StructureSection load='3rk3' size='350' side='right' caption='Human complexin (magenta) as part of the SNARE complex (VAMP2 - cyan; syntaxin - green; SNAP25 (pink and yellow) (PDB entry [[3rk3]])' scene='46/466533/Cv/1'>

	<StructureSection load='3rk3' size='350' side='right' caption='Human complexin (magenta) as part of the SNARE complex (VAMP2 - ~~grey~~; syntaxin - green; SNAP25 (pink and yellow) (PDB entry [[3rk3]])' scene=''>

	== Function ==		== Function ==

Michal Harel at 09:48, 14 December 2015

2015-12-14T09:48:41Z

← Older revision		Revision as of 09:48, 14 December 2015
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	<StructureSection load='3rk3' size='350' side='right' caption='Human complexin (magenta) as part of the SNARE complex (VAMP2 - grey; syntaxin - green; SNAP25 (pink and yellow) (PDB entry [[3rk3]])' scene=''>		<StructureSection load='3rk3' size='350' side='right' caption='Human complexin (magenta) as part of the SNARE complex (VAMP2 - grey; syntaxin - green; SNAP25 (pink and yellow) (PDB entry [[3rk3]])' scene=''>

			== Function ==

			'''Complexin''' (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vesicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vesicle fusion while in another conformation it releases the SNARE complex allowing fusion.<ref>PMID:12200427</ref>

			== Structural highlights ==

			CPLX binds to v-SNARE protein VAMP2 and to t-SNARE proteins SNAP25 and syntaxin.

	'''Complexin''' (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vescicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vescicle fusion while in another conformation it releases the SNARE complex allowing fusion.<ref>PMID:12200427</ref>
	</StructureSection>		</StructureSection>
	==3D structures of complexin==		==3D structures of complexin==

Michal Harel at 09:38, 14 December 2015

2015-12-14T09:38:11Z

← Older revision		Revision as of 09:38, 14 December 2015
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	'''Complexin''' (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vescicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vescicle fusion while in another conformation it releases the SNARE complex allowing fusion.<ref>PMID:~~11742345~~</ref>		'''Complexin''' (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vescicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vescicle fusion while in another conformation it releases the SNARE complex allowing fusion.<ref>PMID:12200427</ref>
	</StructureSection>		</StructureSection>
	==3D structures of complexin==		==3D structures of complexin==

Michal Harel at 09:35, 14 December 2015

2015-12-14T09:35:03Z

← Older revision		Revision as of 09:35, 14 December 2015
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	~~{{STRUCTURE_3rk3\| PDB=3rk3 \| SIZE=400\| SCENE= \|right\|CAPTION=Human complexin (magenta) as part of the SNARE complex (VAMP2 - grey; syntaxin - green; SNAP25 (pink and yellow), [[3rk3]] }}~~

	<StructureSection load='3rk3' size='350' side='right' caption='Human complexin (magenta) as part of the SNARE complex (VAMP2 - grey; syntaxin - green; SNAP25 (pink and yellow) (PDB entry [[3rk3]])' scene=''>		<StructureSection load='3rk3' size='350' side='right' caption='Human complexin (magenta) as part of the SNARE complex (VAMP2 - grey; syntaxin - green; SNAP25 (pink and yellow) (PDB entry [[3rk3]])' scene=''>

Michal Harel at 09:34, 14 December 2015

2015-12-14T09:34:42Z

← Older revision		Revision as of 09:34, 14 December 2015
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	{{STRUCTURE_3rk3\| PDB=3rk3 \| SIZE=400\| SCENE= \|right\|CAPTION=Human complexin (magenta) as part of the SNARE complex (VAMP2 - grey; syntaxin - green; SNAP25 (pink and yellow), [[3rk3]] }}		{{STRUCTURE_3rk3\| PDB=3rk3 \| SIZE=400\| SCENE= \|right\|CAPTION=Human complexin (magenta) as part of the SNARE complex (VAMP2 - grey; syntaxin - green; SNAP25 (pink and yellow), [[3rk3]] }}

			<StructureSection load='3rk3' size='350' side='right' caption='Human complexin (magenta) as part of the SNARE complex (VAMP2 - grey; syntaxin - green; SNAP25 (pink and yellow) (PDB entry [[3rk3]])' scene=''>

	'''Complexin''' (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vescicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vescicle fusion while in another conformation it releases the SNARE complex allowing fusion.

	~~{{TOC limit\|limit=2}}~~

			'''Complexin''' (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vescicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vescicle fusion while in another conformation it releases the SNARE complex allowing fusion.<ref>PMID:11742345</ref>
			</StructureSection>
	==3D structures of complexin==		==3D structures of complexin==

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	[[3rk3]], [[3rl0]] - CPLX + SNARE – human		[[3rk3]], [[3rl0]] - CPLX + SNARE – human
			== References ==
			<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]